Citation: Zhi-Peng Bao, Hefei Yang, Ru-Han A, Yuanrui Wang, Xiao-Feng Wu. Carbonylative five-component synthesis of amides and esters with α-quaternary carbon center[J]. Chinese Chemical Letters, ;2025, 36(11): 111150. doi: 10.1016/j.cclet.2025.111150 shu

Carbonylative five-component synthesis of amides and esters with α-quaternary carbon center

Zhi-Peng Bao ^{a, b} ,
Hefei Yang ^{a, b} ,
Ru-Han A ^{a, b} ,
Yuanrui Wang ^a ,
Xiao-Feng Wu ^{a, b, *,}

a.
Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
b.
Leibniz-Institut für Katalyse e.V., Albert-Einstein-Straβe 29a, 18059 Rostock, Germany

xwu2020@dicp.ac.cn

Received Date: 13 January 2025
Revised Date: 13 March 2025
Accepted Date: 26 March 2025
Available Online: 30 March 2025

Figures(4)

Carboxylic acid derivatives with α-quaternary carbon center are one of the most ubiquitous moieties in synthetic and medicinal chemistry. Hence, novel and efficient synthetic methods towards carboxylic acid derivatives with α-quaternary carbon remain in high demand. However, most of the precursors of these complex compounds are not easy to prepare. Reported herein is a carbonylative five-component synthesis of amides and esters with α-quaternary carbon center enabled by palladium catalysis from abundant acrylonitrile, carbon monoxide, fluoroalkyl halides, and nucleophiles. Diverse amides and esters with α-quaternary carbon which contain difluoromethyl or perfluoroalkyl moiety were prepared in good to excellent yields, providing an efficient synthetic platform for sequential transformations.
- Carbonylation,
- Palladium catalyst,
- Amide,
- Alkene,
- Multi component reaction
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