Citation: Ying Zhang, Chuang Shen, Jiaxu Zhang, Qi Shen, Fei Xu, Shengheng Wang, Jiuyi Hu, Faisal Saleem, Feng Huang, Zhimin Luo. Ultrasmall PtCu nanosheets as a broadband phototheranostic agent in near-infrared biowindow[J]. Chinese Chemical Letters, ;2025, 36(6): 111059. doi: 10.1016/j.cclet.2025.111059 shu

Ultrasmall PtCu nanosheets as a broadband phototheranostic agent in near-infrared biowindow

Ying Zhang ^a ,
Chuang Shen ^a ,
Jiaxu Zhang ^a ,
Qi Shen ^a ,
Fei Xu ^a ,
Shengheng Wang ^a ,
Jiuyi Hu ^b ,
Faisal Saleem ^{b, *,} ,
Feng Huang ^{c, *,} ,
Zhimin Luo ^{a, *,}

a.
State Key Laboratory of Flexible Electronics (LoFE) & Jiangsu Key Laboratory of Smart Biomaterials and Theranostic Technology, Institute of Advanced Materials (IAM), College of Electronic and Optical Engineering & College of Flexible Electronics (Future Technology), School of Chemistry and Life Sciences, Nanjing University of Posts and Telecommunications, Nanjing 210023, China
b.
State Key Laboratory of Flexible Electronics (LoFE) & Institute of Advanced Materials (IAM), School of Flexible Electronics (Future Technologies), Nanjing Tech University (NanjingTech), Nanjing 211816, China
c.
Department of Human Anatomy, Laboratory of Clinical Applied Anatomy, Key Laboratory of Brain Aging and Neurodegenerative Diseases of Fujian Province, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350122, China

iamfaisalsaleem@njtech.edu.cn

huangfeng@fjmu.edu.cn

iamzmluo@njupt.edu.cn

Received Date: 13 January 2025
Revised Date: 4 March 2025
Accepted Date: 7 March 2025
Available Online: 12 March 2025

Figures(6)

Broadband photothermal and photoacoustic agents in the near-infrared (NIR) biowindow are of significance for cancer phototheranostics. In this work, PtCu nanosheets with an average lateral size of less than 10 nm are synthesized as NIR photothermal and photoacoustic agents in vivo, which show strong light absorption from NIR-Ⅰ to NIR-Ⅱ biowindows with the photothermal conversion efficiencies of 20.4% under 808 nm laser and 32.7% under 1064 nm laser. PtCu nanosheets functionalized with folic acid-modified thiol-poly(ethylene glycol) (SH-PEG-FA) present good biocompatibility and 4T1 tumor-targeted effect, which give high-contrast photoacoustic imaging and efficient photothermal ablation of 4T1 tumor in both NIR-Ⅰ and NIR-Ⅱ biowindows. Our work significantly broadens applications of noble metal-based nanomaterials in the fields of cancer phototheranostics by rationally designing their structures and modulating their physicochemical properties.
- Noble metal nanostructures,
- PtCu nanosheets,
- Photothermal therapy,
- Photoacoustic imaging,
- Broadband phototheranostics
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