Citation: Di Zhang, Xu He, Xiaoying Kang, Xue Meng, Ji Qi, Zhifang Wu, Ningbo Li. A photo-accelerated nanoplatform for image-guided synergistic chemo-photodynamic therapy[J]. Chinese Chemical Letters, ;2025, 36(12): 110942. doi: 10.1016/j.cclet.2025.110942 shu

A photo-accelerated nanoplatform for image-guided synergistic chemo-photodynamic therapy

Di Zhang ^{a, b, 1} ,
Xu He ^{b, 1} ,
Xiaoying Kang ^c ,
Xue Meng ^c ,
Ji Qi ^{c, *,} ,
Zhifang Wu ^{a, *,} ,
Ningbo Li ^{b, *,}

a.
Department of Nuclear Medicine, The First Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan 030001, China
b.
School of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, China
c.
State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, Frontiers Science Center for Cell Responses, and College of Life Sciences, Nankai University, Tianjin 300071, China

qiji@nankai.edu.cn

wuzhifang01@163.com

ningboli@sxmu.edu.cn

Received Date: 26 November 2024
Revised Date: 8 February 2025
Accepted Date: 10 February 2025
Available Online: 11 February 2025

Figures(5)

The efficient and safe strategy is highly desirable for effective tumor treatment, yet the development is still unsatisfied. In this work, we develop a photo-accelerated nanoplatform for image-guided synergistic chemo-photodynamic therapy. We first synthesize an aggregation-induced emission luminogen (AIEgen) with outstanding type-Ⅰ and type-Ⅱ photodynamic therapy (PDT) properties. By integrating the high-performance AIEgen with a hypoxia-responsive prodrug and camouflaging with M1 macrophage membrane, a tumor-targeting theranostic agent is created. Upon light trigger, the type-Ⅱ PDT process depletes oxygen in the tumor microenvironment, exacerbating hypoxia and promoting prodrug activation. Meanwhile, the type-Ⅰ PDT mechanism, being less reliant on oxygen, ensures that the overall PDT efficacy remains largely unaffected. Consequently, this light-triggered synergistic PDT-chemotherapy system demonstrates enhanced therapeutic performance. In vivo fluorescence imaging precisely delineates tumor sites, guiding subsequent treatment. The photo-triggered prodrug activation and PDT significantly boost the therapeutic outcomes of the tumor. This approach presents a compelling solution for targeted and efficient tumor treatment.
- Aggregation-induced emission,
- Photodynamic therapy,
- Theranostics,
- Hypoxia,
- Synergistic chemotherapy
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