Citation: Peng Jin, Sili Lin, Dongmei Wang, Jinsong Fan, Qingyun Liu, Kun Li. Valence-band hybridization endows the reaction specificity of AgPd nanozyme for exclusive peroxidase mimicking and improved sensing performance[J]. Chinese Chemical Letters, ;2025, 36(11): 110916. doi: 10.1016/j.cclet.2025.110916 shu

Valence-band hybridization endows the reaction specificity of AgPd nanozyme for exclusive peroxidase mimicking and improved sensing performance

Peng Jin ^{a, b, 1} ,
Sili Lin ^{b, 1} ,
Dongmei Wang ^{b, c, *,} ,
Jinsong Fan ^b ,
Qingyun Liu ^c ,
Kun Li ^{b, *,}

a.
Department of Mathematics and Physics, Luoyang Institute of Science and Technology, Luoyang 471023, China
b.
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology, Hunan University, Changsha 410082, China
c.
College of Chemical and Biological Engineering, Shandong University of Science and Technology, Qingdao 266590, China

wangdm@sdust.edu.cn

kunli@hnu.edu.cn

Received Date: 27 September 2024
Revised Date: 29 December 2024
Accepted Date: 4 February 2025
Available Online: 4 February 2025

Figures(5)

Nanozymes, characterized by their stability, cost-effectiveness, and tunable catalytic activity, are promising alternatives to natural enzymes. However, specifically mimicking a single natural enzyme's activity presents a challenge. By exploiting the catalytic selectivity derived from the valence-band hybridization of noble metal nanoalloys, we introduce an alloying strategy to modulate the reaction specificity of metallic nanozymes. AgPd nanoalloy exhibits enhanced peroxidase-like activity and eliminated oxidase-like activity by adjusting the Ag content. The introduction of Ag changes the hybrid d band energy of the alloyed metal and inhibits the O₂ adsorption and decomposition on Pd, while improving the peroxidase mimicry by allowing for the H₂O₂ activation. By exemplifying the construction of a highly sensitive and selective colorimetric glucose detection platform with its practicality validated in serum samples, this strategy pioneers a multi-noble metal nanozyme with tailored peroxidase activity based on the chemical structure engineering and would advance the development of single-catalytic function nanozymes for building exclusively specific biosensors through reducing substrate competition.
- Reaction specificity,
- Peroxidase,
- Silver,
- Palladium,
- Nanoalloy,
- Glucose detection
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