Citation: Jing Feng, Yanhong Liu, Liming Gong, Chenfei Liu, Congcong Xiao, Liqing Chen, Mingji Jin, Zhonggao Gao, Wei Huang, Yubo Li. Recent progress on drug delivery systems of regulating intratumoral bacteria for tumor therapy[J]. Chinese Chemical Letters, ;2025, 36(11): 110907. doi: 10.1016/j.cclet.2025.110907 shu

Recent progress on drug delivery systems of regulating intratumoral bacteria for tumor therapy

Jing Feng ^{a, b} ,
Yanhong Liu ^c ,
Liming Gong ^{a, b} ,
Chenfei Liu ^{a, b} ,
Congcong Xiao ^{a, b} ,
Liqing Chen ^{a, b} ,
Mingji Jin ^{a, b} ,
Zhonggao Gao ^{a, b, *,} ,
Wei Huang ^{a, b, *,} ,
Yubo Li ^{d, *,}

a.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
b.
Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
c.
Department of Pharmacy, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School of Nanjing Medical University, Suzhou 215000, China
d.
School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China

gaozg@imm.ac.cn

huangwei@imm.ac.cn

yaowufenxi001@sina.com

Received Date: 10 November 2024
Revised Date: 26 January 2025
Accepted Date: 1 February 2025
Available Online: 2 February 2025

Figures(3)

Intratumoral bacteria have been proven to be widely exist in tumors, different tumors of different systems have different types of characteristic bacteria. Intratumoral bacteria will become a new and important biomarker in the full cycle of tumor development. This article emphasizes the key role of intratumoral bacteria in the occurrence and progress of tumors, including promoting tumor development, accelerating tumor metastasis and promoting tumor cell resistance. In addition, this article also summarizes the application of intratumoral bacteria in tumor diagnosis and prognosis. Especially, this article outlines the treatment strategies of intratumoral bacteria, including non-nanodelivery therapy strategies and nanodelivery therapy strategies, such as antibiotic, macromolecular, inflammatory factor inhibitors, near-infrared-photothermal therapy, inorganic antibacterial agents, reactive species and microbes therapy, in these strategies, nano delivery system provides a promising treatment that solves the problem of drug resistance, reducing toxicity and improving patient compliance. This article is hoped to guide future research on intratumoral bacteria on tumors.
- Intratumoral bacteria,
- Occurrence and progress,
- Diagnosis,
- Prognosis,
- Non-nanodelivery systems,
- Nanodelivery systems
1. [1]
  S.P. Walker, M. Tangney, M.J. Claesson, Front. Oncol. 10 (2020) 179. doi: 10.3389/fonc.2020.00179
2. [2]
  C. Xue, Q. Chu, Q. Zheng, et al., Cell Rep. Med. 4 (2023) 100884. doi: 10.1016/j.xcrm.2022.100884
3. [3]
  C.J.F. Heymann, J.M. Bard, M.F. Heymann, et al., Cancer Lett. 522 (2021) 63–79. doi: 10.1016/j.canlet.2021.09.009
4. [4]
  Y. Fu, J. Li, W. Cai, et al., Acta Pharm. Sin. B 14 (2024) 1560–1591. doi: 10.1016/j.apsb.2023.11.018
5. [5]
  L. Yang, A. Li, Y. Wang, Y. Zhang, Signal Transduct. Target. Ther. 8 (2023) 35. doi: 10.1038/s41392-022-01304-4
6. [6]
  D. Nejman, G. Fuks, N. Gavert, et al., Science 368 (2020) 973–980. doi: 10.1126/science.aay9189
7. [7]
  Y. Xie, F. Xie, X. Zhou, et al., Adv. Sci. 9 (2022) 2200470. doi: 10.1002/advs.202200470
8. [8]
  A. Fu, B. Yao, T. Dong, et al., Cell 185 (2022) 1356–1372. doi: 10.1016/j.cell.2022.02.027
9. [9]
  M.R. Wilson, Y. Jiang, P.W. Villalta, et al., Science 363 (2019) eaar7785. doi: 10.1126/science.aar7785
10. [10]
  Z. He, R.Z. Gharaibeh, R.C. Newsome, et al., Gut 68 (2019) 289–300. doi: 10.1136/gutjnl-2018-317200
11. [11]
  Mara R. Rubinstein, X. Wang, W. Liu, et al., Cell Host Microbe. 14 (2013) 195–206. doi: 10.1016/j.chom.2013.07.012
12. [12]
  M.T. Abreu, R.M. Peek, Gastroenterology 146 (2014) 1534–1546. doi: 10.1053/j.gastro.2014.01.001
13. [13]
  G. Leore T, B.R. Michal, D. Tal, et al., Cancer 357 (2017) 1156–1160.
14. [14]
  M. Wang, B. Rousseau, K. Qiu, et al., Nat. Biotechnol. 42 (2023) 1263–1274.
15. [15]
  E. Riquelme, Y. Zhang, L. Zhang, et al., Cell 178 (2019) 795–806. doi: 10.1016/j.cell.2019.07.008
16. [16]
  F. Pentimalli, M. Krstic-Demonacos, C. Costa, et al., Front. Immunol. 14 (2023) 1129513. doi: 10.3389/fimmu.2023.1129513
17. [17]
  L. Sun, X. Ke, A. Guan, et al., Clin. Transl. Med. 13 (2023) 1263–1274. doi: 10.1007/978-981-19-2635-8_90
18. [18]
  C. Gao, X. Wang, B. Yang, et al., ACS Nano 17 (2023) 7335–7351. doi: 10.1021/acsnano.2c11305
19. [19]
  Y. Goto, S. Iwata, M. Miyahara, E. Miyako, Adv. Sci. 10 (2023) 2301679. doi: 10.1002/advs.202301679
20. [20]
  G. Petrov, M. Dymova, V. Richter, Int J. Mol Sci. 23 (2022) 14245. doi: 10.3390/ijms232214245
21. [21]
  H. Miao, N. Wu, C. Luan, et al., Acta Microbiol. Sin. 54(10) (2014) 1228–1234.
22. [22]
  J.L. Galeano Niño, H. Wu, K.D. LaCourse, et al., Nature 611 (2022) 810–817. doi: 10.1038/s41586-022-05435-0
23. [23]
  B. Roje, B. Zhang, E. Mastrorilli, et al., Nature 632 (2024) 1137–1144. doi: 10.1038/s41586-024-07754-w
24. [24]
  E.M. Stoffel, R.E. Brand, M. Goggins, Gastroenterology 164 (2023) 752–765. doi: 10.1053/j.gastro.2023.02.012
25. [25]
  J. Yang, Q. He, F. Lu, et al., Gut Microbes 15 (2023) 2201159. doi: 10.1080/19490976.2023.2201159
26. [26]
  G. Murphy, V. McCormack, B. Abedi-Ardekani, et al., Ann. Oncol. 28 (2017) 2086–2093. doi: 10.1093/annonc/mdx279
27. [27]
  H. Liang, J. Fan, Y. Qiao, Cancer Biol. Med. 1 (2016) 33.
28. [28]
  Y. Masugi, R. Nishihara, J. Yang, et al., Gut 66 (2017) 1463–1473. doi: 10.1136/gutjnl-2016-311421
29. [29]
  K. Mima, Y. Sukawa, R. Nishihara, et al., JAMA Oncol. 1 (2015) 653–661. doi: 10.1001/jamaoncol.2015.1377
30. [30]
  Y. Li, S. Xing, F. Chen, et al., Nat. Commun. 14 (2023) 5788. doi: 10.1038/s41467-023-40987-3
31. [31]
  J.J. Granados-Romero, A.I. Valderrama-Treviño, E.H. Contreras-Flores, et al., Int. J. Res. Med. Sci. 5 (2017) 4667. doi: 10.18203/2320-6012.ijrms20174914
32. [32]
  W.S. Muhammad, C. Edward, Cancer Cell 16 (2010) 196–201.
33. [33]
  Y.Q. Lu, Q. Han, X.R. Tan, et al., Trends MicroBiol. 32 (2024) 807–822. doi: 10.1016/j.tim.2024.01.007
34. [34]
  G. Sambruni, A.D. Macandog, J. Wirbel, et al., Genome Med. 15 (2023) 32. doi: 10.1186/s13073-023-01180-9
35. [35]
  J.H. Huang, J. Wang, X.Q. Chai, et al., MicroBiol. Spectr. 10 (2022) e00983-00922.
36. [36]
  L.D. Wood, M.I. Canto, E.M. Jaffee, D.M. Simeone, Gastroenterology 163 (2022) 386–402. doi: 10.1053/j.gastro.2022.03.056
37. [37]
  N.N. Liu, C.X. Yi, L.Q. Wei, et al., Cancer Cell 41 (2023) 1927–1944. doi: 10.1016/j.ccell.2023.08.012
38. [38]
  A. Wong Rolle, Q. Dong, Y. Zhu, et al., J. Immunother. Cancer 10 (2022) 004698.
39. [39]
  A.K. Markopoulos, Open Dent. J. 6 (2012) 126–130. doi: 10.2174/1874210601206010126
40. [40]
  S. Kalaora, A. Nagler, D. Nejman, et al., Nature 592 (2021) 138–143. doi: 10.1038/s41586-021-03368-8
41. [41]
  K. Vega Escobar, P.O. Armijos, T. Milman, et al., Am. J. Ophthalmol. Case Rep. 30 (2023) 101833. doi: 10.1016/j.ajoc.2023.101833
42. [42]
  G. Zhu, H. Su, C.H. Johnson, et al., Eur. J. Cancer 151 (2021) 25–34. doi: 10.1016/j.ejca.2021.03.053
43. [43]
  B. Aykut, S. Pushalkar, R. Chen, et al., Nature 574 (2019) 264–267. doi: 10.1038/s41586-019-1608-2
44. [44]
  J. Sun, Q. Tang, S. Yu, et al., EBioMedicine 88 (2023) 88.
45. [45]
  C. Neuzillet, M. Marchais, S. Vacher, et al., Sci. Rep. 11 (2021) 7870. doi: 10.1038/s41598-021-86816-9
46. [46]
  B. h. Xian, J. m. Wei, G. b. Qiao, et al., J. Sun Yat-sen Univ. (Med. Sci. ) 43 (2022) 480–487.
47. [47]
  K. Takabe, C. Xuan, J.M. Shamonki, et al., PLoS One 9 (2014) e83744. doi: 10.1371/journal.pone.0083744
48. [48]
  M. Vyara, F. Jessica, B. Riyue, et al., Science 359 (2018) 104–108. doi: 10.1126/science.aao3290
49. [49]
  G.D. Sepich Poore, H. Carter, R. Knight, Cancer Cell 39 (2021) 601–603. doi: 10.1016/j.ccell.2021.04.008
50. [50]
  C. Xue, J. Jia, X. Gu, et al., Signal Transduct. Target. Ther. 7 (2022) 335. doi: 10.1038/s41392-022-01159-9
51. [51]
  K.L. Greathouse, J.R. White, A.J. Vargas, et al., Genome Biol. 19 (2018) 123. doi: 10.1186/s13059-018-1501-6
52. [52]
  J. Massagué, A.C. Obenauf, Nature 529 (2016) 298–306. doi: 10.1038/nature17038
53. [53]
  A. Fu, B. Yao, T. Dong, S. Cai, Trends Cell Biol. 33 (2023) 583–593. doi: 10.1016/j.tcb.2022.11.007
54. [54]
  F. Aikun, Y. Bingqing, D. Tingting, C. Shang, Life Medicine 1 (2022) 61–63. doi: 10.1093/lifemedi/lnac009
55. [55]
  G. Wang, X. He, Q. Wang, Biochim. Biophys. Acta Rev. Cancer 1878 (2023) 188846. doi: 10.1016/j.bbcan.2022.188846
56. [56]
  S. Guo, J. Chen, F. Chen, et al., Gut 70 (2021) 1507–1519. doi: 10.1136/gutjnl-2020-321187
57. [57]
  Y. Zhang, L. Zhang, S. Zheng, et al., Gut Microbes 14 (2022) 2038852. doi: 10.1080/19490976.2022.2038852
58. [58]
  A. Bertocchi, S. Carloni, P.S. Ravenda, et al., Cancer Cell 39 (2021) 708–724. doi: 10.1016/j.ccell.2021.03.004
59. [59]
  L. Parhi, T. Alon-Maimon, A. Sol, et al., Nat. Commun. 11 (2020) 3259. doi: 10.1038/s41467-020-16967-2
60. [60]
  S. Parida, S. Wu, S. Siddharth, et al., Cancer Discov. 11 (2021) 1138–1157. doi: 10.1158/2159-8290.cd-20-0537
61. [61]
  A. Sevcikova, N. Izoldova, V. Stevurkova, et al., Int. J. Mol Sci. 23 (2022) 488. doi: 10.3390/ijms23010488
62. [62]
  A. Tijeras Raballand, M. Hilmi, L. Astorgues-Xerri, et al., Clin. Res. Hepatol Gas 45 (2021) 101589.
63. [63]
  S. Lu, J. Lin, J. Jin, et al., Expert Opin. Drug Discov. 17 (2022) 1407–1423. doi: 10.1080/17460441.2023.2157402
64. [64]
  S.W. Guan, Q. Lin, H.B. Yu, World J. Gastrointest. Oncol. 15 (2023) 713–730. doi: 10.4251/wjgo.v15.i5.713
65. [65]
  X. Huang, C. Chen, W. Xie, et al., Int. J. Radiat. Oncol. Biol. Phys. 117 (2023) 1255–1269. doi: 10.1016/j.ijrobp.2023.06.2515
66. [66]
  E. Riquelme, A. Maitra, F. McAllister, Cancer Discov. 8 (2018) 386–388. doi: 10.1158/2159-8290.CD-18-0123
67. [67]
  K.D. LaCourse, M. Zepeda-Rivera, A.G. Kempchinsky, et al., Cell Rep. 41 (2022) 111625. doi: 10.1016/j.celrep.2022.111625
68. [68]
  M. Hamada, H. Inaba, K. Nishiyama, et al., Int. J. Mol. Sci. 24 (2023) 15456. doi: 10.3390/ijms242015456
69. [69]
  L.E. Colbert, M.B. El Alam, R. Wang, et al., Cancer Cell 41 (2023) 1945–1962. doi: 10.1016/j.ccell.2023.09.012
70. [70]
  M. Zhang, Y. Zhang, Y. Han, et al., Transl. Cancer Res. 11 (2022) 426–434. doi: 10.21037/tcr-22-92
71. [71]
  L. Yuan, P. Yang, G. Wei, et al., Commun. Biol. 5 (2022) 864. doi: 10.1038/s42003-022-03814-x
72. [72]
  R.E. Eckart, E.A. Shry, A.P. Burke, et al., J. Am. Coll. Cardiol. 58 (2011) 1254–1261. doi: 10.1016/j.jacc.2011.01.049
73. [73]
  C. Urbaniak, G.B. Gloor, M. Brackstone, et al., Appl. Environ. Microbiol. 82 (2016) 5039–5048. doi: 10.1128/AEM.01235-16
74. [74]
  T. Dong, A. Fu, S. Cai, STAR Protoc. 3 (2022) 101624. doi: 10.1016/j.xpro.2022.101624
75. [75]
  A. Tzeng, N. Sangwan, M. Jia, et al., Genome Med. 13 (2021) 60. doi: 10.1186/s13073-021-00874-2
76. [76]
  H. Qiao, X.R. Tan, H. Li, et al., JAMA Oncol. 8 (2022) 1301. doi: 10.1001/jamaoncol.2022.2810
77. [77]
  M. Hilmi, C. Neuzillet, J.H. Lefèvre, et al., Cancers 14 (2022) 1606. doi: 10.3390/cancers14071606
78. [78]
  D. Sheng, K. Yue, H. Li, et al., MicroBiol. Spectr. 11 (2023) e03549-03522. doi: 10.1128/spectrum.03549-22
79. [79]
  Y. Li, D. Zhang, M. Wang, et al., iMeta 2 (2023) e102. doi: 10.1002/imt2.102
80. [80]
  Y. Huang, N. Zhu, X. Zheng, et al., Front. Immunol. 13 (2022) 785422. doi: 10.3389/fimmu.2022.785422
81. [81]
  J.L. Alexander, J.M. Posma, A. Scott, et al., Microbiome 11 (2023) 100. doi: 10.1186/s40168-023-01518-w
82. [82]
  A.S. Campbell, D. Albo, T.F. Kimsey, et al., J. Surg. Res. 123 (2005) 96–101. doi: 10.1016/j.jss.2004.07.013
83. [83]
  D. Unutmaz, K.J. Chen, S.Z. Lin, et al., PLoS One 6 (2011) e24671. doi: 10.1371/journal.pone.0024671
84. [84]
  Y. Tomohide, Y. Xuexian O, C. Yeonseok, et al., J. Immunol. 181 (2009) 8391–8401.
85. [85]
  M. Salvucci, N. Crawford, K. Stott, et al., Gut 71 (2021) 1600–1612.
86. [86]
  D. Mouradov, P. Greenfield, S. Li, et al., Gastroenterology 165 (2023) 104–120. doi: 10.1053/j.gastro.2023.03.205
87. [87]
  S. Banerjee, Z. Wei, T. Tian, et al., Cell Death Dis. 12 (2021) 831. doi: 10.1038/s41419-021-04092-x
88. [88]
  R. Brett M, P. Jennifer B, S. Thomas A, Cancer Biol. Med. 14 (2017) 9–32. doi: 10.20892/j.issn.2095-3941.2016.0084
89. [89]
  C. Stewart, C. Ralyea, S. Lockwood, Semin. Oncol. Nurs. 35 (2019) 151–156. doi: 10.1016/j.soncn.2019.02.001
90. [90]
  W. Cheng, L. He, W. Ren, et al., Nano TransMed 2 (2023) 100008. doi: 10.1016/j.ntm.2023.100008
91. [91]
  J. y. Zhang, M. Shen, Clin. Immunol. 17 (2023) 68–73.
92. [92]
  V. Pareek, S. Devineau, S.K. Sivasankaran, et al., Front. Microbiol. 12 (2021) 638640. doi: 10.3389/fmicb.2021.638640
93. [93]
  D.J. Dwyer, M.A. Kohanski, B. Hayete, J.J. Collins, Mol. Syst. Biol. 3 (2007) 91. doi: 10.1038/msb4100135
94. [94]
  G.D. Wright, Cell 130 (2007) 781–783. doi: 10.1016/j.cell.2007.08.023
95. [95]
  Y. Luo, Y. Song, Int. J. Mol. Sci. 22 (2021) 11401. doi: 10.3390/ijms222111401
96. [96]
  W.Y. Cheng, C.Y. Wu, J. Yu, Gut 69 (2020) 1867–1876. doi: 10.1136/gutjnl-2020-321153
97. [97]
  C. Moser, C.J. Lerche, K. Thomsen, et al., APMIS 127 (2019) 361–371. doi: 10.1111/apm.12951
98. [98]
  S.S. Jiang, Y.L. Xie, X.Y. Xiao, et al., Cell Host Microbe 31 (2023) 781–797. doi: 10.3390/f14040781
99. [99]
  Z. Cao, J. Liu, Acc. Mater. Res. 5 (2024) 872–883. doi: 10.1021/accountsmr.4c00116
100. [100]
  J. Yu, B. Zhou, S. Zhang, et al., Nat. Commun. 13 (2022) 7903. doi: 10.1038/s41467-022-35580-z
101. [101]
  L. Wang, Z. Cao, M. Zhang, et al., Adv. Mater. 34 (2021) 2106.
102. [102]
  Q. Han, F. Yang, M. Chen, et al., Adv. Sci. 11 (2024) 2407402. doi: 10.1002/advs.202407402
103. [103]
  K.F. Xu, S.Y. Wu, Z. Wang, et al., Nat. Commun. 15 (2024) 5147. doi: 10.1038/s41467-024-49156-6
104. [104]
  S. Chowdhury, S. Castro, C. Coker, et al., Nat. Med. 25 (2019) 1057–1063. doi: 10.1038/s41591-019-0498-z
105. [105]
  X. Zhang, D. Yu, D. Wu, et al., Cell Host Microbe 31 (2023) 418–432. doi: 10.1007/978-3-031-46674-8_29
106. [106]
  H. Wu, X. Leng, Q. Liu, et al., Cancer Res. 83 (2023) 3131–3144. doi: 10.1158/0008-5472.can-22-2593
107. [107]
  Y. He, L. Fu, Y. Li, et al., Cell Metab. 33 (2021) 988–1000. doi: 10.1016/j.cmet.2021.03.002
108. [108]
  P. Louis, H.J. Flint, FEMS MicroBiol. Lett. 294 (2009) 1–8. doi: 10.1111/j.1574-6968.2009.01514.x
109. [109]
  M.K. Stoeva, J. Garcia-So, N. Justice, et al., Gut Microbes 13 (2021) 1907272. doi: 10.1080/19490976.2021.1907272
110. [110]
  M.J. Bender, A.C. McPherson, C.M. Phelps, et al., Cell 186 (2023) 1846–1862. doi: 10.1016/j.cell.2023.03.011
111. [111]
  H. Wang, X. Rong, G. Zhao, et al., Cell Metab. 34 (2022) 581–594. doi: 10.1016/j.cmet.2022.02.010
112. [112]
  J. Tintelnot, Y. Xu, T.R. Lesker, et al., Nature 615 (2023) 168–174. doi: 10.1038/s41586-023-05728-y
113. [113]
  J. Cong, P. Liu, Z. Han, et al., Immunity 57 (2024) 876–889. doi: 10.1016/j.immuni.2024.02.014
114. [114]
  R. Dey, S. Mukherjee, S. Barman, J. Haldar, Macromol. Biosci. 21 (2021) 2100182. doi: 10.1002/mabi.202100182
115. [115]
  J. Zou, X. Xing, C. Teng, et al., Acta Pharm. Sin. B 14 (2024) 4509–4525. doi: 10.1016/j.apsb.2024.08.014
116. [116]
  W. Chen, K. Shi, Y. Yu, et al., Chin. Chem. Lett. 35 (2024) 109159. doi: 10.1016/j.cclet.2023.109159
117. [117]
  L. Yin, X. Jiang, M. Wang, et al., Chin. Chem. Lett. (2024) 110224. doi: 10.1016/j.cclet.2024.110224
118. [118]
  S. Kwon, H. ThiThu Ngo, J. Son, et al., Nat. Rev. Clin. Oncol. 21 (2024) 569–589. doi: 10.1038/s41571-024-00908-9
119. [119]
  W. Eisenreich, T. Rudel, J. Heesemann, W. Goebel, Front. Cell Infect Microbiol. 12 (2022) 900848. doi: 10.3389/fcimb.2022.900848
120. [120]
  M. Zoulikha, Z. Chen, J. Wu, W. He, Chin. Chem. Lett. 36 (2025) 110225. doi: 10.1016/j.cclet.2024.110225
121. [121]
  L. Chen, R. Zhao, J. Shen, et al., Adv. Mater. 35 (2023) 2306281. doi: 10.1002/adma.202306281
122. [122]
  X. Liu, M. Sun, F. Pu, et al., J. Am. Chem. Soc. 145 (2023) 26296–26307. doi: 10.1021/jacs.3c09472
123. [123]
  Q. Qiu, D. Lu, G. Liu, et al., Bioconjug. Chem. 33 (2022) 1944–1952. doi: 10.1021/acs.bioconjchem.2c00407
124. [124]
  X. Li, Y. Ma, Y. Xin, et al., ACS Appl. Mater. Interfaces. 15 (2023) 14164–14172.
125. [125]
  Z. Ma, H. Wang, Z. Shi, et al., ACS Nano 17 (2023) 5740–5756. doi: 10.1021/acsnano.2c12165
126. [126]
  R. Liu, H. Yang, S. Qu, et al., Aggreg 5 (2023) e423.
127. [127]
  W. Song, K. Tiruthani, Y. Wang, et al., Adv. Mater. 30 (2018) e1805007. doi: 10.1002/adma.201805007
128. [128]
  F. Kong, C. Fang, Y. Zhang, et al., Adv. Sci. 9 (2022) 2105523. doi: 10.1002/advs.202105523
129. [129]
  X. Kang, F. Bu, W. Feng, et al., Adv. Mater. 34 (2022) 2206765. doi: 10.1002/adma.202206765
130. [130]
  H. Zhou, D. Tang, X. Kang, et al., Adv. Sci. 9 (2022) 2200732. doi: 10.1002/advs.202200732
131. [131]
  Q. Chen, Y. Zhu, K. Wang, et al., Nano Today 52 (2023) 101994. doi: 10.1016/j.nantod.2023.101994
132. [132]
  X. Qu, F. Yin, M. Pei, et al., ACS Nano 17 (2023) 11466–11480. doi: 10.1021/acsnano.3c01308
133. [133]
  X. Wang, Q. Chen, Y. Zhu, et al., Signal Transduct. Target. Ther. 8 (2023) 227. doi: 10.1038/s41392-023-01435-2
134. [134]
  D.W. Zheng, X. Dong, P. Pan, et al., Nat. Biomed. Eng. 3 (2019) 717–728. doi: 10.1038/s41551-019-0423-2
135. [135]
  T. Hillman, Nano Particle 1 (2019) 1.
136. [136]
  W. Song, D. Zheng, S. Zeng, et al., ACS Nano 16 (2022) 17402–17413. doi: 10.1021/acsnano.2c08555
137. [137]
  S. Geng, P. Guo, X. Li, et al., ACS Nano 18 (2024) 8971–8987. doi: 10.1021/acsnano.3c12687
138. [138]
  Z. Han, Q. Chen, D. Zheng, et al., Adv. Mater. 35 (2023) 2302551. doi: 10.1002/adma.202302551
139. [139]
  C. Wang, L. Zhong, J. Xu, et al., Nat. BioMed. Eng. 8 (2024) 561–578. doi: 10.1038/s41551-024-01191-w
140. [140]
  Y. Ma, S. Liu, Q. Zhou, et al., Chin. J. Nat. Med. 22 (2024) 699–710.
1. [1]
  Qiongqiong Wan , Zhourui Zhang , Mengmeng Zhao , Xianqin Ruan , Yanhong Hao , Jiajun Deng , Yunlang She , Minglei Yang , Yongxiang Song , Feng Jin , Ailin Wei , Sheng Zhong , Jie Zheng , Dong Xie , Suming Chen . Efficient diagnosis of benign and malignant pulmonary nodules based on Nano-zero-valent iron enhanced serum metabolic fingerprinting. Chinese Chemical Letters, 2025, 36(10): 110794-. doi: 10.1016/j.cclet.2024.110794
2. [2]
  Huimin Gao , Zhuochen Yu , Xuze Zhang , Xiangkun Yu , Jiyuan Xing , Youliang Zhu , Hu-Jun Qian , Zhong-Yuan Lu . A mini review of the recent progress in coarse-grained simulation of polymer systems. Chinese Journal of Structural Chemistry, 2024, 43(5): 100266-100266. doi: 10.1016/j.cjsc.2024.100266
3. [3]
  Linghui Zou , Meng Cheng , Kaili Hu , Jianfang Feng , Liangxing Tu . Vesicular drug delivery systems for oral absorption enhancement. Chinese Chemical Letters, 2024, 35(7): 109129-. doi: 10.1016/j.cclet.2023.109129
4. [4]
  Jialiang XU , Jiabin CUI . Recent biological applications of corroles: From diagnosis to therapy. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2303-2317. doi: 10.11862/CJIC.20240245
5. [5]
  Yujie Li , Ya-Nan Wang , Yin-Gen Luo , Hongcai Yang , Jinrui Ren , Xiao Li . Advances in synthetic biology-based drug delivery systems for disease treatment. Chinese Chemical Letters, 2024, 35(11): 109576-. doi: 10.1016/j.cclet.2024.109576
6. [6]
  Lihang Wang , Mary Li Javier , Chunshan Luo , Tingsheng Lu , Shudan Yao , Bing Qiu , Yun Wang , Yunfeng Lin . Research advances of tetrahedral framework nucleic acid-based systems in biomedicine. Chinese Chemical Letters, 2024, 35(11): 109591-. doi: 10.1016/j.cclet.2024.109591
7. [7]
  Bingwei Wang , Yihong Ding , Xiao Tian . Benchmarking model chemistry composite calculations for vertical ionization potential of molecular systems. Chinese Chemical Letters, 2025, 36(2): 109721-. doi: 10.1016/j.cclet.2024.109721
8. [8]
  Xiaolong Li , Changjiang Li , Chaopeng Shi , Jiarun Wang , Bei Yan , Xianjin Xiao , Tongbo Wu . CRISPR-Cas systems in DNA functional circuits: Strategies, challenges, prospects. Chinese Chemical Letters, 2025, 36(7): 110507-. doi: 10.1016/j.cclet.2024.110507
9. [9]
  Shifang Song , Chenyu Wu , Li Zhang , Dezhi Yang , Yang Lu , Zhengzheng Zhou . Unpacking phase transitions in multi-component drug systems: A case study. Chinese Chemical Letters, 2025, 36(7): 110911-. doi: 10.1016/j.cclet.2025.110911
10. [10]
  Feihu Wu , Gengwen Chen , Kaitao Lai , Shiqing Zhang , Yingchao Liu , Ruijian Luo , Xiaocong Wang , Pinzhi Cao , Yi Ye , Jiarong Lian , Junle Qu , Zhigang Yang , Xiaojun Peng . Non-specific/specific SERS spectra concatenation for precise bacteria classifications with few samples using a residual neural network. Chinese Chemical Letters, 2025, 36(1): 109884-. doi: 10.1016/j.cclet.2024.109884
11. [11]
  Jiaxiang Guo , Zeyi Li , Tianyu Zhang , Xinyu Tian , Yue Wang , Chuandong Dou . Thienothiophene-centered ladder-type π-systems that feature distinct quinoidal π-extension. Chinese Chemical Letters, 2024, 35(5): 109337-. doi: 10.1016/j.cclet.2023.109337
12. [12]
  Ningyue Xu , Jun Wang , Lei Liu , Changyang Gong . Injectable hydrogel-based drug delivery systems for enhancing the efficacy of radiation therapy: A review of recent advances. Chinese Chemical Letters, 2024, 35(8): 109225-. doi: 10.1016/j.cclet.2023.109225
13. [13]
  Chaoqun Ma , Yuebo Wang , Ning Han , Rongzhen Zhang , Hui Liu , Xiaofeng Sun , Lingbao Xing . Carbon dot-based artificial light-harvesting systems with sequential energy transfer and white light emission for photocatalysis. Chinese Chemical Letters, 2024, 35(4): 108632-. doi: 10.1016/j.cclet.2023.108632
14. [14]
  Chi Zhang , Ning Ding , Yuwei Pan , Lichun Fu , Ying Zhang . The degradation pathways of contaminants by reactive oxygen species generated in the Fenton/Fenton-like systems. Chinese Chemical Letters, 2024, 35(10): 109579-. doi: 10.1016/j.cclet.2024.109579
15. [15]
  Lilin Song , Mengru Sun , Yuqing Song , Feng Zhang , Bei Zhao , Hairong Zeng , Jinhui Shi , Huixin Liu , Shanshan Zhao , Tian Tian , Heng Yin , Guangbo Ge . Rationally engineered IR-783 octanoate as an enzyme-activatable fluorogenic tool for functional imaging of hNotum in living systems. Chinese Chemical Letters, 2024, 35(11): 109601-. doi: 10.1016/j.cclet.2024.109601
16. [16]
  Jianmei Guo , Yupeng Zhao , Lei Ma , Yongtao Wang . Ultra-long room temperature phosphorescence, intrinsic mechanisms and application based on host-guest doping systems. Chinese Journal of Structural Chemistry, 2024, 43(9): 100335-100335. doi: 10.1016/j.cjsc.2024.100335
17. [17]
  Yutong Xiong , Ting Meng , Wendi Luo , Bin Tu , Shuai Wang , Qingdao Zeng . Molecular conformational effects on co-assembly systems of low-symmetric carboxylic acids investigated by scanning tunneling microscopy. Chinese Journal of Structural Chemistry, 2025, 44(2): 100511-100511. doi: 10.1016/j.cjsc.2025.100511
18. [18]
  Peng Liu . Cyclodextrins as versatile supramolecular building block in nanoscale drug delivery systems for precise tumor chemotherapy. Chinese Chemical Letters, 2025, 36(11): 111406-. doi: 10.1016/j.cclet.2025.111406
19. [19]
  Peide Zhu , Yangjia Liu , Yaoyao Tang , Siqi Zhu , Xinyang Liu , Lei Yin , Quan Liu , Zhiqiang Yu , Quan Xu , Dixian Luo , Juncheng Wang . Bi-doped carbon quantum dots functionalized liposomes with fluorescence visualization imaging for tumor diagnosis and treatment. Chinese Chemical Letters, 2024, 35(4): 108689-. doi: 10.1016/j.cclet.2023.108689
20. [20]
  Zhe-Han Yang , Jie Yin , Lei Xin , Yuanfang Li , Yijie Huang , Ruo Yuan , Ying Zhuo . Research advancement of DNA-based intelligent hydrogels: Manufacture, characteristics, application of disease diagnosis and treatment. Chinese Chemical Letters, 2024, 35(10): 109558-. doi: 10.1016/j.cclet.2024.109558

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(22)
HTML views(3)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142