Citation: Chao Chen, Wang Geng, Ke Li, Qiong Lei, Zhichao Jin, Xiuhai Gan. Pyridazine: A privileged scaffold in the development of 21^st-century pesticides[J]. Chinese Chemical Letters, ;2025, 36(8): 110902. doi: 10.1016/j.cclet.2025.110902 shu

Pyridazine: A privileged scaffold in the development of 21^st-century pesticides

Chao Chen ^{a, b} ,
Wang Geng ^a ,
Ke Li ^b ,
Qiong Lei ^a ,
Zhichao Jin ^{a, *,} ,
Xiuhai Gan ^{a, *,}

a.
State Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China
b.
State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Natural Products Research Center of Guizhou Province, Guizhou Medical University, Guiyang 550014, China

zcjin@gzu.edu.cn

gxh200719@163.com

Received Date: 20 November 2024
Revised Date: 18 January 2025
Accepted Date: 23 January 2025
Available Online: 27 January 2025

Figures(7)

Pyridazine has garnered increasing attention as a privileged scaffold and bioisosterism in drug discovery due to its unique structural characteristics. It can serve as a hydrogen bond acceptor when interacting with receptors due to its two adjacent nitrogen atoms. Upon conversion to pyridazinone, it exhibits the ability to act as both a hydrogen bond acceptor and donor, showcasing its versatility. This inherent flexibility has prompted extensive research exploring its bioactivity in pesticides and pharmaceuticals. In order to promote the development of pyridazine-based pesticides, this review provides a comprehensive summary of advancements for pyridazine-based pesticides on herbicidal (36.9%), insecticidal (26.2%), antifungal and antibacterial (24.6%), plant growth regulatory (10.8%), and antiviral activities (1.5%) from 2000 to 2024. It serves as an invaluable reference and source of inspiration for agricultural scientists conducting future research.
- Pyridazine,
- Pyridazinone,
- Privilege scaffold,
- Biological activity,
- Pesticide
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沈阳化工大学材料科学与工程学院沈阳 110142

Pyridazine: A privileged scaffold in the development of 21st-century pesticides

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通讯作者: 陈斌, bchen63@163.com

Pyridazine: A privileged scaffold in the development of 21^st-century pesticides