Citation: Hao Hu, Jiacheng Wang, Si Zhang, Ben Zhang, Cuinan Jiang, Hong Tian, Xunxin Gu, Yang Sheng, Zhenghuan Zhao, Meng Li, Lu Zheng, Jing Li. Hierarchical and flexible electrode with precise H₂-production for in vivo liver cancer therapy[J]. Chinese Chemical Letters, ;2025, 36(12): 110866. doi: 10.1016/j.cclet.2025.110866 shu

Hierarchical and flexible electrode with precise H₂-production for in vivo liver cancer therapy

Hao Hu ^{a, 1} ,
Jiacheng Wang ^{b, 1} ,
Si Zhang ^a ,
Ben Zhang ^c ,
Cuinan Jiang ^a ,
Hong Tian ^a ,
Xunxin Gu ^a ,
Yang Sheng ^d ,
Zhenghuan Zhao ^e ,
Meng Li ^{b, *,} ,
Lu Zheng ^{a, *,} ,
Jing Li ^{a, *,}

a.
Department of Hepatobiliary Surgery, Second Affiliated Hospital, Army Medical University, Chongqing 400038, China
b.
MOE Key Laboratory of Low-grade Energy Utilization Technologies and Systems, CQU-NUS Renewable Energy Materials & Devices Joint Laboratory, School of Energy & Power Engineering, Chongqing University, Chongqing 400044, China
c.
Southwest Technology and Engineering Research Institute, Chongqing 400039, China
d.
Jiangsu Key Laboratory of Environmentally Friendly Polymeric Materials, School of Materials Science and Engineering, Changzhou University, Changzhou 213164, China
e.
College of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, China

limeng@cqu.edu.cn

xqyyzl@163.com

xqyylj@163.com

Received Date: 3 November 2024
Revised Date: 14 January 2025
Accepted Date: 15 January 2025
Available Online: 15 January 2025

Figures(5)

Liver cancer is a major killer threatening human health worldwide. At this stage the clinical choice to the treatment of liver cancer is a combination of surgery, chemotherapy and radiotherapy. Alternatively, using hydrogen to treat cancer has great prospects and development space. Herein, we fabricated a hierarchical and flexible electrode that being able to continuously generate hydrogen in vivo in the deep abdominal liver through efficient water electrolysis to kill tumor cells and regulate the tumor microenvironment. The flexibility of the electrode facilitated to fit the tumor surface and thus improved the contact area of hydrogen therapy. By in situ growth of molybdenum disulfide on a hierarchical carbon skeleton, improved reaction kinetics and smaller impedance with a low overpotential of 1.02 V at −10 mA/cm² in cell culture medium and Tafel slope of 73 mV/dec were achieved. Animal experiments showed that the electrode could effectively inhibit the growth of human hepatocellular carcinoma cells in nude mice by efficient H₂-production in vivo. The apoptosis rate of cancer cells reached 81.8%, and the proliferation rate decreased to 3.39%. Moreover, this treatment does not affect the growth of normal hepatocytes according to the results of cell experiments. This study demonstrated that the in vivo hydrogen production by our flexible electrode is a safe and effective treatment for liver cancer, with the advantages of minimal invasiveness, simple operation, low side effects and low cost.
- Hydrogen evolution reaction,
- Liver cancer,
- Hydrogen therapy,
- Cancer therapy,
- Nanoelectrode
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通讯作者: 陈斌, bchen63@163.com

Hierarchical and flexible electrode with precise H₂-production for in vivo liver cancer therapy