Citation: Wei Zhou, Di He, Ning Liu, Ying Li, Wenzhao Han, Weiping Zhou, Siyu Zhang, Cong Yu. A PDI-based NIR-Ⅱ fluorescence imaging guided molecular phototheranostic platform for GSH-triggered gas therapy, mild photothermal therapy and NIR-activated photodynamic therapy[J]. Chinese Chemical Letters, ;2025, 36(11): 110854. doi: 10.1016/j.cclet.2025.110854 shu

A PDI-based NIR-Ⅱ fluorescence imaging guided molecular phototheranostic platform for GSH-triggered gas therapy, mild photothermal therapy and NIR-activated photodynamic therapy

Wei Zhou ^{a, b} ,
Di He ^a ,
Ning Liu ^a ,
Ying Li ^a ,
Wenzhao Han ^a ,
Weiping Zhou ^{a, b} ,
Siyu Zhang ^{a, b} ,
Cong Yu ^{a, b, *,}

a.
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
b.
University of Science and Technology of China, Hefei 230026, China

congyu@ciac.ac.cn

Received Date: 11 November 2024
Revised Date: 13 January 2025
Accepted Date: 14 January 2025
Available Online: 15 January 2025

Figures(7)

Synergistic therapy using multiple modalities is a highly promising therapeutic strategy. Near-infrared-Ⅱ (NIR-Ⅱ) fluorescence imaging, with its deep penetration and high fidelity, has frequently been employed in the literature to guide and assist treatment. Herein, we report the development of a NIR-Ⅱ fluorescence imaging guided multi-therapy platform PDI-DS NPs, which integrates a novel activatable phototheranostic agent PDI-DBU, a H₂S donor DPS and an amphiphilic polymer DSPE-mPEG2000. In order to maximize redshift of absorption and emission of PDI derivatives, we introduced an electron donating group DBU on PDI to obtain PDI-DBU. PDI-DBU exhibits a distinct absorption band at 700–900 nm and demonstrates excellent NIR-Ⅱ fluorescence emission/imaging properties and good photothermal effects under 808 nm laser irradiation. More importantly, under 808 nm laser irradiation, PDI-DBU could be oxidized, and the photodynamic effect of the material could be subsequently activated under 530 nm laser irradiation, achieving the combination of photothermal and activatable photodynamic dual modality treatment. The H₂S donor DPS, when triggered by the abundant glutathione (GSH) within the tumor microenvironment (TME), is capable of generating H₂S. On one hand, H₂S can inhibit tumor growth by disrupting mitochondrial function, on the other hand, it can also repress the expression of heat shock protein 90 (HSP90), thereby reversing tumor cell resistance mechanism against photothermal therapy. The utilization of PDI-DS NPs combined with DPS for efficient tumor ablation has been successfully demonstrated both in vitro and in vivo. This synergistic therapeutic platform thus offers a promising strategy in the field of NIR-Ⅱ fluorescence imaging guided tumor therapy.
- Perylene diimide probe,
- NIR-Ⅱ fluorescence,
- Imaging-guided therapy,
- Gas therapy,
- Photothermal therapy,
- NIR activated photodynamic therapy
1. [1]
  R. Siegel, K. Miller, A. Jemal, CA Cancer J. Clin. 69 (2019) 7–34. doi: 10.3322/caac.21551
2. [2]
  G. Wu, X. Wu, X. Zhu, J. Xu, N. Bao, ACS Nano 16 (2022) 10130–10155. doi: 10.1021/acsnano.2c02841
3. [3]
  M. Tan, Y. Xu, Z. Gao, et al., Adv. Mater. 34 (2022) 2108491. doi: 10.1002/adma.202108491
4. [4]
  C. Domingues, A. Santos, C. Alvarez-Lorenzo, et al., ACS Nano 16 (2022) 9994–10041. doi: 10.1021/acsnano.2c00128
5. [5]
  X. Han, C. Gong, Q. Yang, et al., Int. J. Nanomed. 19 (2024) 571–608. doi: 10.2147/ijn.s442877
6. [6]
  Y. Su, B. Liu, B. Wang, et al., Small 20 (2024) 2310342. doi: 10.1002/smll.202310342
7. [7]
  T. Hu, L. Jia, H. Li, et al., Adv. Healthc. Mater. 13 (2024) 2303147. doi: 10.1002/adhm.202303147
8. [8]
  X. Chu, P. Zhang, Y. Wang, et al., Carbon 176 (2021) 126–138. doi: 10.1016/j.carbon.2021.01.119
9. [9]
  X. Li, J. Chen, S. Liu, et al., ACS Appl. Nano Mater. 6 (2023) 17728–17739. doi: 10.1021/acsanm.3c03000
10. [10]
  J. Wang, P. Chen, Y. Dong, et al., Biomaterials 276 (2021) 121056. doi: 10.1016/j.biomaterials.2021.121056
11. [11]
  H. He, X. Zhang, L. Du, et al., Adv. Drug Deliv. Rev. 186 (2022) 114320. doi: 10.1016/j.addr.2022.114320
12. [12]
  H. He, L. Du, H. Xue, et al., Small Method. 7 (2023) 2300230. doi: 10.1002/smtd.202300230
13. [13]
  C. Li, Y. Cheng, D. Li, et al., Int. J. Mol. Sci. 23 (2022) 7909. doi: 10.3390/ijms23147909
14. [14]
  L. Lv, B. Fan, X. Ji, et al., Coord. Chem. Rev. 507 (2024) 215733. doi: 10.1016/j.ccr.2024.215733
15. [15]
  K. Yang, B. Yu, W. Liu, et al., Chin. Chem. Lett. 34 (2023) 107889. doi: 10.1016/j.cclet.2022.107889
16. [16]
  X. Lv, X. Ran, Y. Zhao, et al., Chin. Chem. Lett. 36 (2025) 110027. doi: 10.1016/j.cclet.2024.110027
17. [17]
  Y. Wang, S. Luo, Y. Wu, et al., ACS Nano 14 (2020) 17046–17062. doi: 10.1021/acsnano.0c06415
18. [18]
  C. Liu, S. Li, R. Ma, et al., Nano Today 42 (2022) 101363. doi: 10.1016/j.nantod.2021.101363
19. [19]
  L. Feng, D. Tao, Z. Dong, et al., Biomaterials 127 (2017) 13–24. doi: 10.1016/j.biomaterials.2016.11.027
20. [20]
  X. Chen, Z. Zhang, W. Luo, et al., Biomaterials 287 (2022) 121680. doi: 10.1016/j.biomaterials.2022.121680
21. [21]
  J. Miao, Y. Huo, G. Yao, et al., Angew. Chem. Int. Ed. 61 (2022) e202201815. doi: 10.1002/anie.202201815
22. [22]
  C. Zhao, W. Liu, W. Sun, et al., Anal. Chim. Acta 1231 (2022) 340198. doi: 10.1016/j.aca.2022.340198
23. [23]
  X. Min, F. Yi, X.L. Han, et al., Chem. Eng. J. 432 (2022) 134327. doi: 10.1016/j.cej.2021.134327
24. [24]
  G. Yang, C. Chen, Y. Zhu, et al., ACS Appl. Mater. Interfaces 11 (2019) 44961–44969. doi: 10.1021/acsami.9b15996
25. [25]
  J. Shen, D. Chen, Y. Liu, et al., J. Mater. Chem. B 9 (2021) 4826–4831. doi: 10.1039/d1tb00937k
26. [26]
  L. Hu, Y. Xu, Y. Zhao, et al., Chem. Eng. J. 476 (2023) 146829. doi: 10.1016/j.cej.2023.146829
27. [27]
  C. Wang, S. Lv, Z. Sun, et al., Aggregate 5 (2024) 587–600. doi: 10.1002/agt2.587
28. [28]
  Y. Yu, H. Wang, Z. Zhuang, et al., ACS Nano 18 (2024) 13019–13034. doi: 10.1021/acsnano.4c01600
29. [29]
  P. Ghaffari, H. Jafari, O. Okoro, et al., Small Method (2024) 2301349.
30. [30]
  Q. Wang, C. Zhang, Y. Zhao, et al., Biomaterials 309 (2024) 122606. doi: 10.1016/j.biomaterials.2024.122606
31. [31]
  S. Li, Z. Chen, W. Guo, et al., Adv. Funct. Mater. 34 (2024) 2314742. doi: 10.1002/adfm.202314742
32. [32]
  S. Wan, J. Zeng, H. Cheng, X. Zhang, Biomaterials 185 (2018) 51–62. doi: 10.1016/j.biomaterials.2018.09.004
33. [33]
  S. Liu, J. Ma, X. Xu, A. Wang, N. Zheng, Sci. China Chem. 67 (2024) 1624–1635. doi: 10.1007/s11426-023-1917-8
34. [34]
  S. Liu, C. Li, H. Lee, et al., Medicina 60 (2024) 245. doi: 10.3390/medicina60020245
35. [35]
  J. Cheng, Y. Zhu, Y. Dai, et al., Angew. Chem. Int. Ed. 62 (2023) e202304312. doi: 10.1002/anie.202304312
36. [36]
  X. Guo, J. Liu, L. Jiang, et al., J. Nanobiotechnol. 19 (2021) 321. doi: 10.1186/s12951-021-01042-9
37. [37]
  G. Wu, F. Liu, N. Li, et al., Adv. Sci. 10 (2023) 2304104. doi: 10.1002/advs.202304104
38. [38]
  X. Liang, M. Kurboniyon, Y. Zou, et al., Pharmaceutics 15 (2023) 2443. doi: 10.3390/pharmaceutics15102443
39. [39]
  Y. Su, B. Yu, S. Wang, H. Cong, Y. Shen, Biomaterials 271 (2021) 120717. doi: 10.1016/j.biomaterials.2021.120717
40. [40]
  J. Xu, A. Gulzar, P. Yang, et al., Coord. Chem. Rev. 381 (2019) 104–134. doi: 10.1016/j.ccr.2018.11.014
41. [41]
  J. Wang, Y. Liu, M. Morsch, et al., Adv. Mater. 34 (2021) 2106082.
42. [42]
  J. Xu, N. Zhu, Y. Du, et al., Nat. Commun. 15 (2024) 2845. doi: 10.1038/s41467-024-47063-4
43. [43]
  H. Dang, Y. Tian, Q. Cheng, et al., J. Colloid. Interface Sci. 612 (2022) 287–297. doi: 10.1016/j.jcis.2021.12.177
44. [44]
  J. Li, L. Xie, B. Li, et al., Adv. Mater. 33 (2021) 2008481. doi: 10.1002/adma.202008481
45. [45]
  W. Tang, Z. Yang, S. Wang, et al., ACS Nano 12 (2018) 2610–2622. doi: 10.1021/acsnano.7b08628
46. [46]
  P. Sun, P. Yuan, G. Wang, et al., Biomacromolecules 18 (2017) 3375–3386. doi: 10.1021/acs.biomac.7b01029
47. [47]
  Y. Ding, Z. Tong, L. Jin, et al., Adv. Mater. 34 (2022) 2106388. doi: 10.1002/adma.202106388
48. [48]
  Y. Cai, D. Ni, W. Cheng, et al., Angew. Chem. Int. Ed. 59 (2020) 14014–14018. doi: 10.1002/anie.202001107
49. [49]
  W. Zhou, D. He, K. Zhang, et al., Biosens. Bioelectron. 259 (2024) 116424. doi: 10.1016/j.bios.2024.116424
50. [50]
  X. Li, F. Fang, B. Sun, et al., Nanoscale Horiz. 6 (2021) 177–185. doi: 10.1039/d0nh00672f
51. [51]
  Y. Liu, P. Bhattarai, Z. Dai, X. Chen, Chem. Soc. Rev. 48 (2019) 2053–2108. doi: 10.1039/C8CS00618K
52. [52]
  C. Park, T. Ha, M. Kim, et al., Biosens. Bioelectron. 105 (2018) 151–158. doi: 10.1016/j.bios.2018.01.018
53. [53]
  T. Ubuka, J. Chromatogr. B 781 (2002) 227–249. doi: 10.1016/S1570-0232(02)00623-2
54. [54]
  X. He, S. Zhang, Y. Tian, W. Cheng, H. Jing, Int. J. Nanomed. 18 (2023) 1433–1468. doi: 10.2147/ijn.s405020
55. [55]
  T. Chou, Pharmacol. Rev. 58 (2006) 621–681. doi: 10.1124/pr.58.3.10
56. [56]
  Y. Hu, X. Li, Y. Fang, et al., Chem. Sci. 10 (2019) 7690–7694. doi: 10.1039/c9sc02323b
57. [57]
  K. Wang, Y. Li, X. Wang, et al., Nat. Commun. 14 (2023) 2950. doi: 10.1038/s41467-023-38601-7
58. [58]
  G. Ma, X. Zhang, K. Zhao, et al., ACS Nano 18 (2024) 3369–3381. doi: 10.1021/acsnano.3c10249
1. [1]
  Yanyan Ma , Lizhen Xu , Muxin Xu , Jie Niu , Wei Xu , Weiying Lin . All in one: An in-situ activated tumor theranostic agent for NIR-Ⅱ fluorescence imaging guided surgical resection and photothermal therapy. Chinese Chemical Letters, 2025, 36(11): 110850-. doi: 10.1016/j.cclet.2025.110850
2. [2]
  Lintao Wu , Yujia Meng , Xumei Zheng , Yiqiao Bai , Chun Han , Zhijun Wang , Jie Yang , Xiaobi Jing , Yong Yao . Pillar[5]arene based prodrug as a GSH-responsive SO₂ nanogenerator for effective gas cancer therapy. Chinese Chemical Letters, 2025, 36(9): 110808-. doi: 10.1016/j.cclet.2024.110808
3. [3]
  Leichen Wang , Anqing Mei , Na Li , Xiaohong Ruan , Xu Sun , Yu Cai , Jinjun Shao , Xiaochen Dong . Aza-BODIPY dye with unexpected bromination and high singlet oxygen quantum yield for photoacoustic imaging-guided synergetic photodynamic/photothermal therapy. Chinese Chemical Letters, 2024, 35(6): 108974-. doi: 10.1016/j.cclet.2023.108974
4. [4]
  Xuejian Xing , Pan Zhu , E Pang , Shaojing Zhao , Yu Tang , Zheyu Hu , Quchang Ouyang , Minhuan Lan . D-A-D-structured boron-dipyrromethene with aggregation-induced enhanced phototherapeutic efficiency for near-infrared fluorescent and photoacoustic imaging-guided synergistic photodynamic and photothermal cancer therapy. Chinese Chemical Letters, 2024, 35(10): 109452-. doi: 10.1016/j.cclet.2023.109452
5. [5]
  Yu Qin , Mingyang Huang , Chenlu Huang , Hannah L. Perry , Linhua Zhang , Dunwan Zhu . O₂-generating multifunctional polymeric micelles for highly efficient and selective photodynamic-photothermal therapy in melanoma. Chinese Chemical Letters, 2024, 35(7): 109171-. doi: 10.1016/j.cclet.2023.109171
6. [6]
  Mingrui Zhang , Lingyu Jin , Yuda Zhu , Junfeng Kou , Bo Liu , Jing Chen , Xiaolin Zhong , Xianghua Wu , Junfeng Zhang , Wenxiu Ren . A near-infrared Ⅱ fluorescent dye based on oxanthracene: Real-time imaging of drug-induced acute liver injury and photothermal therapy for tumor. Chinese Chemical Letters, 2025, 36(10): 110772-. doi: 10.1016/j.cclet.2024.110772
7. [7]
  Tingting Hu , Chao Shen , Xueyan Wang , Fengbo Wu , Zhiyao He . Tumor microenvironment-sensitive polymeric nanoparticles for synergetic chemo-photo therapy. Chinese Chemical Letters, 2024, 35(11): 109562-. doi: 10.1016/j.cclet.2024.109562
8. [8]
  Lulu He , Le Wang , Zhen He , Yiqian Yang , Cheng Heng Pang , Aiguo Wu , Bencan Tang , Juan Li . An imine-linked covalent organic framework with intrinsic photo-induced mitochondrial regulation for breast cancer therapy. Chinese Chemical Letters, 2025, 36(9): 110717-. doi: 10.1016/j.cclet.2024.110717
9. [9]
  Xiao-Fang Lv , Xiao-Yun Ran , Yu Zhao , Rui-Rui Zhang , Li-Na Zhang , Jing Shi , Ji-Xuan Xu , Qing-Quan Kong , Xiao-Qi Yu , Kun Li . Combing NIR-Ⅱ molecular dye with magnetic nanoparticles for enhanced photothermal theranostics with a 95.6% photothermal conversion efficiency. Chinese Chemical Letters, 2025, 36(4): 110027-. doi: 10.1016/j.cclet.2024.110027
10. [10]
  Songtao Cai , Liuying Wu , Yuan Li , Soham Samanta , Jinying Wang , Bing Liu , Feihu Wu , Kaitao Lai , Yingchao Liu , Junle Qu , Zhigang Yang . Intermolecular hydrogen-bonding as a robust tool toward significantly improving the photothermal conversion efficiency of a NIR-II squaraine dye. Chinese Chemical Letters, 2024, 35(4): 108599-. doi: 10.1016/j.cclet.2023.108599
11. [11]
  Yuliang Yang , Jingyi Zhang , Yu Wang , Huan Chen , Yijian Gao , Xiliang Li , Yingpeng Wan , Qi Zhao , Ning Li , Shengliang Li . Quintuple-acceptor engineering of anti-quenching conjugated oligomers for highly efficient NIR-Ⅱb imaging and phototheranostics. Chinese Chemical Letters, 2025, 36(11): 110834-. doi: 10.1016/j.cclet.2025.110834
12. [12]
  Baoli Yin , Xinlin Liu , Zhe Li , Zhifei Ye , Youjuan Wang , Xia Yin , Sulai Liu , Guosheng Song , Shuangyan Huan , Xiao-Bing Zhang . Ratiometric NIR-Ⅱ fluorescent organic nanoprobe for imaging and monitoring tumor-activated photodynamic therapy. Chinese Chemical Letters, 2025, 36(5): 110119-. doi: 10.1016/j.cclet.2024.110119
13. [13]
  Yiling Li , Zekun Gao , Xiuxiu Yue , Minhuan Lan , Xiuli Zheng , Benhua Wang , Shuang Zhao , Xiangzhi Song . FRET-based two-photon benzo[a] phenothiazinium photosensitizer for fluorescence imaging-guided photodynamic therapy. Chinese Chemical Letters, 2024, 35(7): 109133-. doi: 10.1016/j.cclet.2023.109133
14. [14]
  Du Liu , Yuyan Li , Hankun Zhang , Benhua Wang , Chaoyi Yao , Minhuan Lan , Zhanhong Yang , Xiangzhi Song . Three-in-one erlotinib-modified NIR photosensitizer for fluorescence imaging and synergistic chemo-photodynamic therapy. Chinese Chemical Letters, 2025, 36(2): 109910-. doi: 10.1016/j.cclet.2024.109910
15. [15]
  Zekun Gao , Xiuli Zheng , Weimin Liu , Jie Sha , Shuaishuai Bian , Haohui Ren , Jiasheng Wu , Wenjun Zhang , Chun-Sing Lee , Pengfei Wang . GSH-activatable copper-elsinochrome off-on photosensitizer for combined specific NIR-Ⅱ two-photon photodynamic/chemodynamic therapy. Chinese Chemical Letters, 2025, 36(3): 109874-. doi: 10.1016/j.cclet.2024.109874
16. [16]
  Lulu Cao , Yikun Li , Dongxiang Zhang , Shuai Yue , Rong Shang , Xin-Dong Jiang , Jianjun Du . Engineering aggregates of julolidine-substituted aza-BODIPY nanoparticles for NIR-II photothermal therapy. Chinese Chemical Letters, 2024, 35(12): 109735-. doi: 10.1016/j.cclet.2024.109735
17. [17]
  Xiangqian Cao , Chenkai Yang , Xiaodong Zhu , Mengxin Zhao , Yilin Yan , Zhengnan Huang , Jinming Cai , Jingming Zhuang , Shengzhou Li , Wei Li , Bing Shen . Synergistic enhancement of chemotherapy for bladder cancer by photothermal dual-sensitive nanosystem with gold nanoparticles and PNIPAM. Chinese Chemical Letters, 2024, 35(8): 109199-. doi: 10.1016/j.cclet.2023.109199
18. [18]
  Yongkang Yue , Zhou Xu , Kaiqing Ma , Fangjun Huo , Xuemei Qin , Kuanshou Zhang , Caixia Yin . HSA shrinkage optimizes the photostability of embedded dyes fundamentally to amplify their efficiency as photothermal materials. Chinese Chemical Letters, 2024, 35(8): 109223-. doi: 10.1016/j.cclet.2023.109223
19. [19]
  Yiqiao Chen , Ao Liu , Biwen Yang , Zhenzhen Li , Binggang Ye , Zhouyi Guo , Zhiming Liu , Haolin Chen . Photoluminescence and photothermal conversion in boric acid derived carbon dots for targeted microbial theranostics. Chinese Chemical Letters, 2024, 35(9): 109295-. doi: 10.1016/j.cclet.2023.109295
20. [20]
  Bairui Zeng , Zhixiang Mu , Tianxi Shen , Xiaoliang Qi , Yuanqi Chen , Kezheng Lei , Chen Huang , Yi Wang , Rongdang Hu , Xiaojun Cai , Jianliang Shen , Hui Deng . A self-propelled nanovesicle with robust antibacterial and regeneration-promoting capabilities for treating biofilm-induced periodontitis. Chinese Chemical Letters, 2025, 36(6): 110350-. doi: 10.1016/j.cclet.2024.110350

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(23)
HTML views(2)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142