Citation: Yanyan Ma, Lizhen Xu, Muxin Xu, Jie Niu, Wei Xu, Weiying Lin. All in one: An in-situ activated tumor theranostic agent for NIR-Ⅱ fluorescence imaging guided surgical resection and photothermal therapy[J]. Chinese Chemical Letters, ;2025, 36(11): 110850. doi: 10.1016/j.cclet.2025.110850 shu

All in one: An in-situ activated tumor theranostic agent for NIR-Ⅱ fluorescence imaging guided surgical resection and photothermal therapy

Yanyan Ma ^{a, 1} ,
Lizhen Xu ^{b, 1} ,
Muxin Xu ^b ,
Jie Niu ^{a, *,} ,
Wei Xu ^{a, *,} ,
Weiying Lin ^{b, *,}

a.
Department of Otolaryngology-Head and Neck Surgery, Shandong Institute of Otorhinolaryngology, Shandong Provincial Key Medical and Health Laboratory of Theranostic Fluorescent Materials for Head and Neck Cancer, Shandong Provincial ENT Hospital, Shandong University, Ji'nan 250022, China
b.
Institute of Optical Materials and Chemical Biology, Guangxi Key Laboratory of Electrochemical Energy Materials, School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China

jienie2016@126.com

xuwhns@126.com

weiyinglin2013@163.com

Received Date: 17 October 2024
Revised Date: 8 January 2025
Accepted Date: 13 January 2025
Available Online: 13 January 2025

Figures(6)

Cancer is one of the main causes of death throughout the world. Radical elimination of tumor is crucial for a successful treatment. However, during cancer treatment, it is difficult to distinguish tumor boundaries with the naked eye and to accurately exterminate it. In this work, based on the overexpression of H₂S in some tumors, an activatable second near-infrared (NIR-Ⅱ) theranostic agent (NRS) for distinguishing tumor tissues from normal tissues, guiding surgical resection and ablating tumor tissues by efficient photothermal therapy is proposed. This developed probe NRS can emit fluorescence in the range of 900–1100 nm and detect tumor tissues with H₂S overexpression. Under the guidance of NIR-Ⅱ fluorescence imaging, the tumor margins can be delineated clearly with high signal-to-background ratio. In addition, with the help of NIR-Ⅱ fluorescence surgery navigation, tumors tissues can be precisely resected. More importantly, the probe displays a high photothermal conversion efficiency and can efficiently induce tumor cells apoptosis under 808 nm laser irradiation. By using the desirable attributes of NRS, the tumor tissues with H₂S overexpression was successfully ablated. This work provides a new tool for the future precision eradicate tumors without recurrence, which may have translational potential in biological and clinical systems.
- NIR-Ⅱ fluorescence imaging,
- Photothermal therapy,
- Fluorescence-guided resection,
- Tumor,
- Hydrogen sulfide
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