Citation: Yuan Yan, Lingqi Shen, Yu Wang, Bincheng Gong, Zuguang Li, Hongdeng Qiu. Development of switchable deep eutectic solvents: Applications in extraction of natural products[J]. Chinese Chemical Letters, ;2025, 36(11): 110845. doi: 10.1016/j.cclet.2025.110845 shu

Development of switchable deep eutectic solvents: Applications in extraction of natural products

Yuan Yan ^{a, 1} ,
Lingqi Shen ^{a, 1} ,
Yu Wang ^a ,
Bincheng Gong ^a ,
Zuguang Li ^{a, *,} ,
Hongdeng Qiu ^{b, *,}

a.
College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China
b.
Key Laboratory of Rare Earths, Ganjiang Innovation Academy, Chinese Academy of Sciences, Ganzhou 341000, China

lzg@zjut.edu.cn

hdqiu@licp.cas.cn

Received Date: 28 September 2024
Revised Date: 27 November 2024
Accepted Date: 11 January 2025
Available Online: 13 January 2025

Figures(8)

Green extraction of bioactive components from natural sources has been a hot topic in the field of chemistry and biology. As a kind of green solvents, deep eutectic solvents (DESs) have unique advantages in the extraction of bioactive substances. In recent years, as a new subgroup of DESs, the switchable deep eutectic solvents (SDESs) can realize reversible phase switching between hydrophobic and hydrophilic by external driving forces (CO₂/pH/temperature), allowing for the extraction of different polar components while avoiding the problem of difficult recovery of DESs. The application of SDESs reduces the consumption of large amounts of organic solvents during the extraction process, thereby promoting sustainability. In the meanwhile, it presents an advantage over traditional extraction methods in preserving product activity. Based on the recent researches on SDESs, this work summarized the composition, driving factors, and conversion mechanism of SDESs. The applications of SDESs in the extraction of natural products were primarily highlighted to provide a reference for future research.
- Switchable deep eutectic solvents,
- Natural products,
- Activity retention,
- Extraction,
- Review
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沈阳化工大学材料科学与工程学院沈阳 110142