Citation: Li Qin, Wenjing Wei, Keqing Wang, Xianbao Shi, Guixia Ling, Peng Zhang. Ultrasound-responsive heterojunction sonosensitizers for multifunctional synergistic sonodynamic therapy[J]. Chinese Chemical Letters, ;2025, 36(7): 110777. doi: 10.1016/j.cclet.2024.110777 shu

Ultrasound-responsive heterojunction sonosensitizers for multifunctional synergistic sonodynamic therapy

Li Qin ^a ,
Wenjing Wei ^a ,
Keqing Wang ^a ,
Xianbao Shi ^b ,
Guixia Ling ^{a, *,} ,
Peng Zhang ^{a, *,}

a.
Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China
b.
Department of Pharmacy, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121000, China

Received Date: 8 October 2024
Revised Date: 12 December 2024
Accepted Date: 18 December 2024
Available Online: 19 December 2024

Figures(5)

Sonodynamic therapy (SDT) is a new non-invasive treatment method, which uses low-intensity ultrasound (US) to activate specific sonosensitizers (SNs) to produce reactive oxygen species (ROS) for therapeutic purposes. However, traditional sonosensitizers have the defects of low generation efficiency of ROS and single treatment mode. Therefore, designing sonosensitizers with high efficiency to generate ROS, high stability, and multimodal therapy is an excellent alternative to achieve effective, safe, and intelligent therapy. Heterojunction nanosonosensitizers (NSNs), as novel type of SNs, combine different materials through heterojunction structures to improve the efficiency of ROS generation. In this review, the classification of heterojunction NSNs, the preparation methods and characterization methods of heterojunction NSNs and the possible mechanisms for enhancing SDT were firstly presented, followed by an in-depth discussion of the application of heterojunction NSNs in the treatment of bacterial infections and tumors, with a special emphasis on synergistic enhancement of therapeutic efficacy of heterojunction SNs in combination with different therapeutic models such as gas therapy, immunotherapy and nanocatalytic therapy. Finally, the challenges and perspectives of such heterojunction SNs-supported SDT were outlined and highlighted to facilitate their clinical translation.
- Ultrasound,
- Heterojunction,
- Sonosensitizers,
- Reactive oxygen species,
- Sonodynamic therapy
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沈阳化工大学材料科学与工程学院沈阳 110142