Citation: Aijia Zhang, Guiyuan Zhao, Guangli Xiang, Rui Chen, Yu Dong, Qijie Diao, Jialin Wang, Xiaohui Lin, Wenxuan Zeng, Tianze Jiang, Jun Wu, Xia Zhao. Barnacle-inspired chitosan glycerin gel for skin protection and wound healing in harsh environments[J]. Chinese Chemical Letters, ;2025, 36(8): 110767. doi: 10.1016/j.cclet.2024.110767 shu

Barnacle-inspired chitosan glycerin gel for skin protection and wound healing in harsh environments

Aijia Zhang ^a ,
Guiyuan Zhao ^a ,
Guangli Xiang ^a ,
Rui Chen ^a ,
Yu Dong ^a ,
Qijie Diao ^a ,
Jialin Wang ^a ,
Xiaohui Lin ^a ,
Wenxuan Zeng ^a ,
Tianze Jiang ^a ,
Jun Wu ^{c, d, *,} ,
Xia Zhao ^{a, b, *,}

a.
Key Laboratory of Marine Drugs, Ministry of Education, Shandong Provincial Key Laboratory of Glycoscience and Glycotherapeutics, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
b.
Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao 266237, China
c.
Bioscience and Biomedical Engineering Thrust, The Hong Kong University of Science and Technology (Guangzhou), Guangzhou 511400, China
d.
Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong SAR 999077, China

junwuhkust@ust.uk

Received Date: 10 October 2024
Revised Date: 10 December 2024
Accepted Date: 13 December 2024
Available Online: 15 December 2024

Figures(5)

Skin protection and wound healing in harsh environments such as seawater, cold, and dryness face great challenges. However, traditional hydrogels tend to lose adhesion underwater, freeze at low temperatures, and dehydrate in dry environments, severely limiting their applications. Inspired by marine barnacles, a chitosan (CTS)‑butyl acrylate (BA)-glycerol gel (CB-G-Gel) is fabricated, which mimic the electrostatic and hydrophobic interactions of barnacle cement proteins using CTS and BA respectively to enhance adhesion underwater, and employ a glycerol/water solvent exchange strategy to endow the gel with anti-freezing and water-retaining properties. CB-G-Gel exhibits strong underwater adhesion and good antibacterial activity, and promotes seawater-immersed wound healing. CB-G-Gel protects the skin from frostbite and scald (−196~120 ℃), and has excellent water retention under dry conditions of 20% relative humidity and 60 ℃. This strategy of combining barnacle biomimicry with glycerol/water solvent exchange provides a guidance for skin protection and wound healing in harsh environments.
- Anti-freezing,
- Water retention,
- Underwater adhesion,
- Solvent exchange,
- Hydrogel
1. [1]
  J. Liu, Z. Chen, Y. Chen, et al., Adv. Funct. Mater. 31 (2021) 2101464.
2. [2]
  M. Zhao, M. Kang, J. Wang, et al., Adv. Mater. 36 (2024) 2401369.
3. [3]
  Y. Liang, H. Xu, Z. Li, et al., Nano-Micro Lett. 14 (2022) 185. doi: 10.1007/s10971-022-05822-z
4. [4]
  K. Lei, M. Chen, P. Guo, et al., Adv. Funct. Mater. 33 (2023) 2303511.
5. [5]
  M. Chen, W. Wang, J. Fang, et al., Int. J. Biol. Macromol. 241 (2023) 124496.
6. [6]
  X. Ming, W. Zhong, Y. Ke, et al., Chem. Eng. J. 460 (2023) 141746.
7. [7]
  X. Fan, W. Zhou, Y. Chen, et al., ACS Appl. Mater. Inter. 12 (2020) 32031–32040. doi: 10.1021/acsami.0c09917
8. [8]
  C. Cai, H. Zhu, Y. Chen, et al., Adv. Healthc. Mater. 12 (2023) 2301477.
9. [9]
  J. Song, S. Chen, L. Sun, et al., Adv. Mater. 32 (2020) 1906994.
10. [10]
  Y. Zhao, Y. Chen, X. Song, et al., Adv. Funct. Mater. 33 (2023) 2304439.
11. [11]
  G. Ge, K. Mandal, R. Haghniaz, et al., Adv. Funct. Mater. 33 (2023) 2207388.
12. [12]
  R. Zhou, Y. Jin, W. Zeng, et al., Adv. Funct. Mater. 34 (2024) 2316687.
13. [13]
  T. Essock-Burns, N.V. Gohad, B. Orihuela, et al., J. Exp. Biol. 220 (2017) 194–207.
14. [14]
  X. Wang, Y. Guo, J. Li, et al., ACS Appl. Mater. Inter. 14 (2022) 36166–36177. doi: 10.1021/acsami.2c10202
15. [15]
  Z. Ni, H. Yu, L. Wang, et al., Adv. Healthc. Mater. 11 (2022) 2101421.
16. [16]
  Y. Chen, L. Chang, Z. Zhang, et al., Chem. Eng. J. 480 (2024) 148067.
17. [17]
  P. Nezhad-Mokhtari, H. Hamishehkar, M.R. Farahpour, et al., Chem. Eng. J. 489 (2024) 150992.
18. [18]
  H. Montazerian, A. Hassani Najafabadi, E. Davoodi, et al., Adv. Healthc. Mater. 12 (2023) 2203404.
19. [19]
  H. Fan, J. Wang, J.P. Gong, Adv. Funct. Mater. 31 (2021) 2009334.
20. [20]
  B. Yi, T. Li, B. Yang, et al., Nat. Commun. 15 (2024) 239.
21. [21]
  J. Wang, X.Y. Li, H.L. Qian, et al., Adv. Mater. 36 (2024) 2310216.
22. [22]
  G. Zhao, A. Zhang, X. Chen, et al., Bioact. Mater. 41 (2024) 46–60.
23. [23]
  L. Han, K. Liu, M. Wang, et al., Adv. Funct. Mater. 28 (2018) 1704195.
24. [24]
  X. Huang, Z. Zheng, H. Wang, et al., Adv. Funct. Mater. 34 (2024) 2312149.
25. [25]
  X. Jiang, X. Zhou, K. Ding, et al., Adv. Funct. Mater. 34 (2024) 2400936.
26. [26]
  L. Xu, S. Gao, Q. Guo, et al., Adv. Mater. 32 (2020) 2004579.
27. [27]
  W. Niu, J. Zhu, W. Zhang, X. Liu, ACS Mater. Lett. 4 (2022) 410–417. doi: 10.1021/acsmaterialslett.1c00826
28. [28]
  C. Jiang, W. Xie, D. Wu, A.C.S. Appl, Polym. Mater. 5 (2023) 370–380. doi: 10.1021/acsapm.2c01546
29. [29]
  Y. Duan, F. Jiang, Q. Li, et al., Carbohyd. Polym. 332 (2024) 121912.
30. [30]
  L. Rui, M. Xie, B. Hu, et al., Carbohyd. Polym. 170 (2017) 206–216.
31. [31]
  F. Liu, L. Wang, X. Zhai, et al., Carbohyd. Polym. 322 (2023) 121344.
32. [32]
  Z. Bai, X. Wang, M. Zheng, et al., Adv. Funct. Mater. 33 (2023) 2212856.
33. [33]
  Y. Fu, Z. Wang, K. Wu, et al., Chin. Chem. Lett. 36 (2025) 110479. doi: 10.1016/j.cclet.2024.110479
34. [34]
  R. Si, Y. Wang, Y. Yang, et al., Chem. Eng. J. 489 (2024) 151419.
35. [35]
  Y. Feng, S. Wang, Y. Li, et al., Adv. Funct. Mater. 33 (2023) 2211027.
36. [36]
  Y. Lv, F. Cai, Y. He, et al., Acta Biomater. 159 (2023) 95–110.
37. [37]
  S. Cheng, M. Pan, D. Hu, et al., Chin. Chem. Lett. 34 (2023) 108276.
38. [38]
  Z. Zhang, Q. Zhang, S. Gao, et al., Acta Biomater. 166 (2023) 254–265. doi: 10.56028/aehssr.8.1.254.2023
39. [39]
  L. Hu, Y. Wang, Q. Liu, et al., Chin. Chem. Lett. 34 (2023) 108262.
40. [40]
  W. Zhang, B. Wang, G. Xiang, et al., ACS Appl. Mater. Inter. 15 (2023) 22830–22842. doi: 10.1021/acsami.2c23321
41. [41]
  G. Xiang, B. Wang, W. Zhang, et al., Acta Biomater. 182 (2024) 245–259.
42. [42]
  S. He, B. Guo, X. Sun, et al., ACS Appl. Mater. Inter. 14 (2022) 45869–45879. doi: 10.1021/acsami.2c13371
1. [1]
  Xiaoyu Hou , Mingyang Liu , Hu Wu , Nan Wang , Xu Zhao , Xifeng Qin , Xiaomin Su , Hanwei Huang , Zihan Ma , Jiahao Liu , Onder Ergonul , Füsun Can , Wei Liu , Zhiqing Pang , Funan Liu . Differential releasing hydrogel loaded with oncolytic viruses and anti-CAFs drug to enhance oncology therapeutic efficacy. Chinese Chemical Letters, 2025, 36(5): 110106-. doi: 10.1016/j.cclet.2024.110106
2. [2]
  Mengchen Liu , Yufei Zhang , Yi Xiao , Yang Wei , Meichen Bi , Huaide Jiang , Yan Yu , Shenghong Zhong . High stretchability and toughness of liquid metal reinforced conductive biocompatible hydrogels for flexible strain sensors. Chinese Journal of Structural Chemistry, 2025, 44(3): 100518-100518. doi: 10.1016/j.cjsc.2025.100518
3. [3]
  Xi Chen , Xue Zhang , Shuai Yang , Jie Wang , Tian Tang , Maling Gou . An adhesive hydrogel for the treatment of oral ulcers. Chinese Chemical Letters, 2025, 36(3): 110021-. doi: 10.1016/j.cclet.2024.110021
4. [4]
  Zhuan Chen , Bo Yang , Jun Li , Kun Du , Jiangchen Fu , Xiao Wu , Jiazhen Cao , Mingyang Xing . Environmentally safe storage and sustained release of hydrogen peroxide utilizing commercial hydrogel. Chinese Chemical Letters, 2025, 36(6): 110320-. doi: 10.1016/j.cclet.2024.110320
5. [5]
  Zeyang Yao , Xinru You , Xudong Wang , Yunze Kang , Liying Wang , Ziji Zhang . Stem cell-based hydrogel for the repair and regeneration of cartilage. Chinese Chemical Letters, 2025, 36(8): 110607-. doi: 10.1016/j.cclet.2024.110607
6. [6]
  Ningyue Xu , Jun Wang , Lei Liu , Changyang Gong . Injectable hydrogel-based drug delivery systems for enhancing the efficacy of radiation therapy: A review of recent advances. Chinese Chemical Letters, 2024, 35(8): 109225-. doi: 10.1016/j.cclet.2023.109225
7. [7]
  Tong Zhang , Xiaojing Liang , Licheng Wang , Shuai Wang , Xiaoxiao Liu , Yong Guo . An ionic liquid assisted hydrogel functionalized silica stationary phase for mixed-mode liquid chromatography. Chinese Chemical Letters, 2025, 36(1): 109889-. doi: 10.1016/j.cclet.2024.109889
8. [8]
  Ningning Gao , Yue Zhang , Zhenhao Yang , Lijing Xu , Kongyin Zhao , Qingping Xin , Junkui Gao , Junjun Shi , Jin Zhong , Huiguo Wang . Ba²⁺/Ca²⁺ co-crosslinked alginate hydrogel filtration membrane with high strength, high flux and stability for dye/salt separation. Chinese Chemical Letters, 2024, 35(5): 108820-. doi: 10.1016/j.cclet.2023.108820
9. [9]
  Yang Xu , Le Ma , Yang Wang , Chunmeng Shi . Engineering strategies of biomaterial-assisted exosomes for skin wound repair: Latest advances and challenges. Chinese Chemical Letters, 2025, 36(1): 109766-. doi: 10.1016/j.cclet.2024.109766
10. [10]
  Yue Sun , Yingnan Zhu , Jiahang Si , Ruikang Zhang , Yalan Ji , Jinjie Fan , Yuze Dong . Glucose-activated nanozyme hydrogels for microenvironment modulation via cascade reaction in diabetic wound. Chinese Chemical Letters, 2025, 36(4): 110012-. doi: 10.1016/j.cclet.2024.110012
11. [11]
  Ruijun Song , Huixu Xie , Guiting Liu . Advances of MXene-based hydrogels for chronic wound healing. Chinese Chemical Letters, 2025, 36(7): 110442-. doi: 10.1016/j.cclet.2024.110442
12. [12]
  Mengyu Chen , Qinglin Zhou , Tianyun Qin , Ningyao Sun , Yuxi Chen , Yuwei Gong , Xingyi Li , Jinsong Liu . An ionic liquid-reinforced gelatin hydrogel with strong adhesion, antibacterial and anti-inflammatory properties for treating oral ulcers. Chinese Chemical Letters, 2025, 36(7): 110441-. doi: 10.1016/j.cclet.2024.110441
13. [13]
  Ke Qiu , Fengmei Wang , Mochou Liao , Kerun Zhu , Jiawei Chen , Wei Zhang , Yongyao Xia , Xiaoli Dong , Fei Wang . A Fumed SiO₂-based Composite Hydrogel Polymer Electrolyte for Near-Neutral Zinc-Air Batteries. Acta Physico-Chimica Sinica, 2024, 40(3): 2304036-0. doi: 10.3866/PKU.WHXB202304036
14. [14]
  Bingyang Lu , Dehui Wang , Junchang Guo , Yang Shen , Qian Feng , Jinlong Yang , Xiao Han , Huali Yu , Luohuizi Li , Jiaxin Liu , Jing Luo , Huan Liu , Zhongwei Zhang , Xu Deng . High-efficiency exudates drainage of anti-adhesion dressings for chronic wound. Chinese Chemical Letters, 2025, 36(4): 110601-. doi: 10.1016/j.cclet.2024.110601
15. [15]
  Qiang Zhou , Pingping Zhu , Wei Shao , Wanqun Hu , Xuan Lei , Haiyang Yang . Innovative Experimental Teaching Design for 3D Printing High-Strength Hydrogel Experiments. University Chemistry, 2024, 39(6): 264-270. doi: 10.3866/PKU.DXHX202310064
16. [16]
  Qingyang Cui , Feng Yu , Zirun Wang , Bangkun Jin , Wanqun Hu , Wan Li . From Jelly to Soft Matter: Preparation and Properties-Exploring of Different Kinds of Hydrogels. University Chemistry, 2024, 39(9): 338-348. doi: 10.3866/PKU.DXHX202309046
17. [17]
  Jiawei Ge , Xian Wang , Heyuan Tian , Hao Wan , Wei Ma , Jiangying Qu , Junjie Ge . Iridium-based catalysts for oxygen evolution reaction in proton exchange membrane water electrolysis. Chinese Chemical Letters, 2025, 36(5): 109906-. doi: 10.1016/j.cclet.2024.109906
18. [18]
  Zhi Li , Wenpei Li , Shaoping Jiang , Chuan Hu , Yuanyu Huang , Maxim Shevtsov , Huile Gao , Shaobo Ruan . Legumain-triggered aggregable gold nanoparticles for enhanced intratumoral retention. Chinese Chemical Letters, 2024, 35(7): 109150-. doi: 10.1016/j.cclet.2023.109150
19. [19]
  Changle Liu , Mingyuzhi Sun , Haoran Zhang , Xiqian Cao , Yuqing Li , Yingtang Zhou . All in one doubly pillared MXene membrane for excellent oil/water separation, pollutant removal, and anti-fouling performance. Chinese Journal of Structural Chemistry, 2024, 43(8): 100355-100355. doi: 10.1016/j.cjsc.2024.100355
20. [20]
  Xiaoliu Liang , Chunliu Huang , Hui Liu , Hu Chen , Jiabao Shou , Hongwei Cheng , Gang Liu . Natural hydrogel dressings in wound care: Design, advances, and perspectives. Chinese Chemical Letters, 2024, 35(10): 109442-. doi: 10.1016/j.cclet.2023.109442

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(17)
HTML views(1)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142