Citation: Jiajie Gu, Jiaxiang Gu, Lei Yu. Selenium and Alzheimer's disease[J]. Chinese Chemical Letters, ;2025, 36(8): 110727. doi: 10.1016/j.cclet.2024.110727 shu

Selenium and Alzheimer's disease

Jiajie Gu ^a ,
Jiaxiang Gu ^{a, b, *,} ,
Lei Yu ^{c, *,}

a.
Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou 225001, China
b.
Department of Hand and Foot, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou University, Yangzhou 225001, China
c.
School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China

gjx69@163.com

yulei@yzu.edu.cn

Received Date: 27 May 2024
Revised Date: 26 November 2024
Accepted Date: 5 December 2024
Available Online: 6 December 2024

Figures(4)

Selenium is an essential trace element for human beings and it plays a significant role for the health of human nervous system. The strong antioxidant effect of selenium endows the element with the ability to treat various diseases, including Alzheimer's disease (AD). In the body, selenium exists in the forms of selenoproteins, which could treat AD through various pathways, such as inhibiting peroxidation, inhibiting apoptosis signal pathway, reducing the levels of Aβ in neurons and alleviating Tau protein caused by pathological damage. This article aims to comprehensively elaborate on the relationship between selenium and AD.
- Selenium,
- Alzheimer's disease,
- Selenoprotein,
- Treatment,
- Antioxidant
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