Citation: Kai Zhu, Lei Yang, Yang Yang, Yanqi Wu, Fengzhi Zhang. Recent advances toward the catalytic enantioselective synthesis of planar chiral cyclophanes[J]. Chinese Chemical Letters, ;2025, 36(7): 110678. doi: 10.1016/j.cclet.2024.110678 shu

Recent advances toward the catalytic enantioselective synthesis of planar chiral cyclophanes

Kai Zhu ^{a, b} ,
Lei Yang ^a ,
Yang Yang ^b ,
Yanqi Wu ^c ,
Fengzhi Zhang ^{c, *,}

a.
School of Medicine, Huanghuai University, Zhumadian 463000, China
b.
Zhumadian Central Hospital, Affiliated Hospital of Huanghuai University, Zhumadian 463000, China
c.
School of Pharmacy, Hangzhou Medical College, Hangzhou 310014, China

zhangfengzhi@hmc.edu.cn

Received Date: 11 August 2024
Revised Date: 18 November 2024
Accepted Date: 25 November 2024
Available Online: 26 November 2024

Figures(34)

Planar chiral cyclophanes are a type of structurally intriguing organic molecules, which have found increasingly applications in the field of biologically active compounds, asymmetric catalysis, and optically pure materials. As such, significant efforts in the development of new methods to build up enantioenriched cyclophanes in a precise manner have attracted increased attention in recent years. Among the plethora of reported synthetic strategies, catalytic enantioselective method has emerged as one of the most straightforward and efficient ways to deliver optically pure planar chiral cyclophanes. In this review, the recent progress in catalytic enantioselective reactions for the synthesis of planar chiral cyclophanes will be discussed, which would stimulate the research interest of chemists for the discovery of novel asymmetric strategies for the preparation of valuable and previously difficult-to-access chiral molecules.
- Planar chirality,
- Cyclophanes,
- Asymmetric catalysis,
- Atropisomer,
- Synthetic method
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