Citation: Hao Chang, Renzhong Qiao, Chao Li. Recent advances in functionalized macrocyclic polyamines for medicine applications[J]. Chinese Chemical Letters, ;2025, 36(7): 110675. doi: 10.1016/j.cclet.2024.110675 shu

Recent advances in functionalized macrocyclic polyamines for medicine applications

State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China

qiao_group@163.com

lichao@mail.buct.edu.cn

Received Date: 22 July 2024
Revised Date: 21 November 2024
Accepted Date: 25 November 2024
Available Online: 26 November 2024

Figures(16)

Macrocyclic polyamines are excellent chelating agents with the advantage of forming highly stable complexes. They offer the flexibility to adjust the coordination environment through functionalization. making them valuable in numerous applications owing to their unique chemical and biological characteristics. This review summarizes the use of macrocyclic polyamines as carriers and molecular platforms of targeted drugs for medical applications. The significance and innovative design of these original approaches are dissected from the unique perspective of diverse mechanisms, such as iron depletion, metallo-β-lactamases inhibitors, intracellular ATP depletion, non-viral gene vector, DNA/RNA syntheses inhibitors and theranostics agent. Of interest are the metal complex of macrocyclic polyamines, which is usually a double-edged sword as dealing with endogenous macromolecular targets, especially DNA. These excellent cases will help to understand the typical mechanism in drug design based on macrocyclic polyamines, and achieve actual applications in medicine.
- Macrocyclic polyamine,
- Metal chelators,
- ATP depletion,
- DNA protection and damage
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