Citation: Qiuting Zhang, Fan Wu, Jin Liu, Hang Su, Yanhui Zhong, Zian Lin. Facile synthesis of single-crystal 3D covalent organic frameworks as stationary phases for high-performance liquid chromatographic separation[J]. Chinese Chemical Letters, ;2025, 36(8): 110649. doi: 10.1016/j.cclet.2024.110649 shu

Facile synthesis of single-crystal 3D covalent organic frameworks as stationary phases for high-performance liquid chromatographic separation

Ministry of Education Key Laboratory of Analytical Science for Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou 350108, China

zianlin@fzu.edu.cn

Received Date: 4 May 2024
Revised Date: 15 October 2024
Accepted Date: 13 November 2024
Available Online: 14 November 2024

Figures(5)

Covalent organic frameworks (COFs) have demonstrated great potential in chromatographic separation because of unique structure and superior performance. Herein, single-crystal three-dimensional (3D) COFs with regular morphology, good monodispersity and high specific surface area, were used as a stationary phase for high-performance liquid chromatography (HPLC). The single-crystal 3D COFs packed column not only exhibits high efficiency in separating hydrophobic molecules involving substituted benzenes, halogenated benzenes, halogenated nitrobenzenes, aromatic amines, aromatic hydrocarbons (PAHs) and phthalate esters (PAEs), but also achieves baseline separation of acenaphthene and acenaphthylene with similar physical and chemical properties as well as environmental pollutants, which cannot be quickly separated on commercial C18 column and a polycrystalline 3D COFs packed column. Especially, the column efficiency of 17303-24255 plates/m was obtained for PAEs, and the resolution values for acenaphthene and acenaphthylene, and carbamazepine (CBZ) and carbamazepine-10, 11-epoxide (CBZEP) were 1.7 and 2.2, respectively. This successful application not only confirmed the great potential of the single-crystal 3D COFs in HPLC separation of the organic molecules, but also facilitates the application of COFs in separation science.
- Single-crystal 3D covalent organic frameworks,
- High-performance liquid chromatography,
- Stationary phase,
- Separation
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