Citation: Junliang Zhou, Tian-Bing Ren, Lin Yuan. The strategy to improve the brightness of organic small-molecule fluorescent dyes for imaging[J]. Chinese Chemical Letters, ;2025, 36(8): 110644. doi: 10.1016/j.cclet.2024.110644 shu

The strategy to improve the brightness of organic small-molecule fluorescent dyes for imaging

State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China

rentianbing@hnu.edu.cn

lyuan@hnu.edu.cn

Received Date: 23 September 2024
Revised Date: 8 November 2024
Accepted Date: 11 November 2024
Available Online: 12 November 2024

Figures(18)

Organic small molecule fluorophores have been widely used in biology and biochemistry to study cellular structures and processes at high spatial and temporal resolution. Small-molecule dyes offer various benefits, such as high photostability, low molecular weight, and great biocompatibility. However, the poor brightness of most of conventional dyes in biological environments limits their use in high-quality super-resolution fluorescence imaging. Chemists have conceived and developed many methods to enhance the brightness of fluorophores, including structural alterations that raise extinction coefficients and quantum yields. This review outlines current attempts and substantial advances achieved by chemists to improve the brightness of organic small-molecule fluorescent dyes, such as scaffold rigidification and twisted intramolecular charge transfer (TICT) inhibition. We think that this review will help researchers understand the chemical mechanisms involved in increasing the brightness of fluorophores for biological applications.
- Small-molecule fluorescent dyes,
- Brightness,
- Fluorescence quantum yield,
- TICT,
- Structure modification
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沈阳化工大学材料科学与工程学院沈阳 110142