Citation: Jun-Yang Wang, Yu-Qing Wei, Qing-Ning Wang, Zhi-Guo Wang, Rui Hong, Lisha Yi, Ping Xu, Jia-Zhuang Xu, Zhong-Ming Li, Baisong Zhao. Mucus-inspired lubricative antibacterial coating to reduce airway complications in an intubation cynomolgus monkey model[J]. Chinese Chemical Letters, ;2025, 36(8): 110559. doi: 10.1016/j.cclet.2024.110559 shu

Mucus-inspired lubricative antibacterial coating to reduce airway complications in an intubation cynomolgus monkey model

Jun-Yang Wang ^{a, b} ,
Yu-Qing Wei ^b ,
Qing-Ning Wang ^c ,
Zhi-Guo Wang ^d ,
Rui Hong ^d ,
Lisha Yi ^e ,
Ping Xu ^a ,
Jia-Zhuang Xu ^{b, d, *,} ,
Zhong-Ming Li ^{f, g} ,
Baisong Zhao ^{a, *,}

a.
Department of Anesthesiology, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China
b.
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China
c.
Department of Anesthesiology, The Affiliated Panyu Central Hospital of Guangzhou Medical University, Guangzhou 511400, China
d.
Medicine and Engineering Interdisciplinary Research Laboratory of Nursing & Materials, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu 610041, China
e.
Department of Obstetrics and Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China
f.
West China Hospital/West China School of Medicine, Sichuan University, Chengdu 610041, China
g.
State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China

jzxu@scu.edu.cn

zhaobaisong819@smu.edu.cn

Received Date: 28 August 2024
Revised Date: 14 October 2024
Accepted Date: 16 October 2024
Available Online: 18 October 2024

Figures(5)

Endotracheal intubation-related complications are common in clinical, and there are currently no effective strategies to address these matters. Inspired by the biological characteristics of human airway mucus (HAM), an artificial airway mucus (ARM) coating is straightforwardly constructed by combining carboxymethyl chitosan with methyl cellulose. The ARM coating exhibited excellent lubricity (coefficient of friction (CoF) = 0.05) and hydrophilicity (water contact angle (WCA) = 21.3°), and was capable of coating both the internal and external surfaces of the endotracheal tube (ETT). In vitro experiments demonstrated that the ARM coating not only showed good broad-spectrum antibacterial activity, but also significantly reduced nonspecific protein adhesion. Through an in vivo intubation cynomolgus monkey model, ARM-coated ETT potently mitigated airway injury and inflammation, and was highly potential to prevent bacterial infection and catheter blockage. This work offers a promising avenue for the development of airway-friendly invasive devices.
- Endotracheal intubation,
- Biomimetic,
- Surface modification,
- Lubrication,
- Intubation-related complications
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