Citation: Yongjian Liu, Cen Liu, Haitao Guo, Jinchai Qi, Heng Chen, Yuping Yang, Tao Ma, Yonggang Liu. Alkaloids peganumiums A–C from Peganum harmala L., with two novel long conjugated structures[J]. Chinese Chemical Letters, ;2025, 36(8): 110558. doi: 10.1016/j.cclet.2024.110558 shu

Alkaloids peganumiums A–C from Peganum harmala L., with two novel long conjugated structures

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China

201701033@bucm.edu.cn

liuyg0228@163.com

Received Date: 1 September 2024
Revised Date: 11 October 2024
Accepted Date: 16 October 2024
Available Online: 18 October 2024

Figures(4)

From the seeds of Peganum harmala L., three new alkaloids of β-carboline were isolated. Among them, peganumiums A (1) and B (2) were dimers with specific new scaffolds, all with long conjugated systems. Peganumium A and peganumium C (3) were ionic alkaloid salts and peganumium B was a hexacyclic-condensed alkaloid. The biosynthetic pathways of the three compounds above were also speculated. A preliminary cytotoxicity assay revealed that peganumium B had strong in vitro antiproliferative ability against a variety of cancer cells. The analysis of ¹H nuclear magnetic resonance (NMR) metabolomics suggested that the antiproliferative mechanism of peganumium B could be associated with the biosynthesis of phenylalanine, tyrosine and tryptophan, the metabolism of glycine, serine, and threonine, the metabolism of taurine and hypotaurine, and the metabolism of nicotinate and nicotinamide. In addition, peganumium B could reduce the mitochondrial content of body-wall muscle cells of a Caenorhabditis elegans (C. elegans) strain in vivo.
- Peganum harmala L.,
- Alkaloids,
- β-Carboline,
- Dimers,
- New scaffolds,
- Cytotoxicity
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沈阳化工大学材料科学与工程学院沈阳 110142