Citation: Wei-Ming Huang, Yue-You Yang, Ping Ying, Yu-Qian Cai, Tian-Jie Cao, Chuan-Lu Fu, Ling-Yi Kong, Wen-Jun Xu. Houpolignols A–D, enantiomeric obovatol oligomeric neolignans with anti-NASH activities from Magnolia officinalis var. biloba[J]. Chinese Chemical Letters, ;2025, 36(7): 110522. doi: 10.1016/j.cclet.2024.110522 shu

Houpolignols A–D, enantiomeric obovatol oligomeric neolignans with anti-NASH activities from Magnolia officinalis var. biloba

Wei-Ming Huang ^a ,
Yue-You Yang ^a ,
Ping Ying ^b ,
Yu-Qian Cai ^a ,
Tian-Jie Cao ^a ,
Chuan-Lu Fu ^a ,
Ling-Yi Kong ^{a, *,} ,
Wen-Jun Xu ^{a, *,}

a.
Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China
b.
College of Traditional Chinese Medicine and Health Industry, Lishui University, Lishui 323000, China

cpu_lykong@126.com

wjxu@cpu.edu.cn

Received Date: 6 August 2024
Revised Date: 28 September 2024
Accepted Date: 29 September 2024
Available Online: 30 September 2024

Figures(5)

Houpolignols A–C (1–3), unprecedented oligomers of dearomatized obovatol with tetracyclo[9.3.1.0^{2, 7}.0^{9, 14}]pentadecane (1 and 2) and 8, 18-dioxapentacyclo[13.3.1.1^{5, 9}.0^{4, 16}.0^{13, 20}]icosane (3) core structures, together with their biosynthetic congener houpolignol D (4), were isolated from the cortex of Magnolia officinalis var. biloba. Their structures were determined by spectroscopic analyses, X-ray crystallography data, and quantum chemical calculations. Radical cascade cyclizations were proposed as crucial biosynthetic steps of 1–4. (±)-1 showed anti-nonalcoholic steatohepatitis (NASH) effect by promoting fatty acid beta-oxidation.
- Magnolia officinalis,
- Neolignan,
- Houpolignols A–D,
- Radical cyclization,
- Anti-NASH,
- Obovatol
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