Citation: Jiyang Liu, Xiangzhang Tao, Zhenlei Zou, Jia Xu, Hui Shu, Yi Pan, Weigang Zhang, Shengyang Ni, Yi Wang. Modular and practical synthesis of gem-difluoroalkenes via consecutive Ni-catalyzed reductive cross-coupling[J]. Chinese Chemical Letters, ;2025, 36(7): 110461. doi: 10.1016/j.cclet.2024.110461 shu

Modular and practical synthesis of gem-difluoroalkenes via consecutive Ni-catalyzed reductive cross-coupling

State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China

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wgzhang@nju.edu.cn

nishengyanghi@qq.com

yiwang@nju.edu.cn

Received Date: 14 July 2024
Revised Date: 30 August 2024
Accepted Date: 13 September 2024
Available Online: 14 September 2024

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Transition-metal-catalyzed tandem cross-coupling reactions can rapidly construct complex molecules, but they often suffer from site- and regio- selectivity issues. Here, we designed a novel nickel-catalyzed three-component cross-electrophile coupling (cXEC) platform that enables access to valuable gem-difluoroalkenes. This multicomponent reaction proceeds through a chemoselective alkenylation of aryl halides, followed by alkylation of α-(trifluoromethyl)styrenes, providing a streamlined pathway towards this kind of building blocks.
- BTP,
- Consecutive cross-electrophile coupling,
- gem-Difluoroalkenes,
- Nickel catalysis
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