Citation: Zhiqiang Cui, Dongxiang Zhang, Yanru Huang, Chunyu Shao, Yiming Zhang, Changliang Sun, Xin-Dong Jiang, Xiaohong Sun, Qinghuan Xiao. Novel 1-phenylethyl-containing aza-BDOIPY for phototherapy and simultaneous monitoring of tumor immune microenvironment reprogramming[J]. Chinese Chemical Letters, ;2025, 36(7): 110460. doi: 10.1016/j.cclet.2024.110460 shu

Novel 1-phenylethyl-containing aza-BDOIPY for phototherapy and simultaneous monitoring of tumor immune microenvironment reprogramming

Zhiqiang Cui ^{a, c, 1} ,
Dongxiang Zhang ^{b, 1} ,
Yanru Huang ^{b, 1} ,
Chunyu Shao ^b ,
Yiming Zhang ^b ,
Changliang Sun ^b ,
Xin-Dong Jiang ^{b, *,} ,
Xiaohong Sun ^{a, c, *,} ,
Qinghuan Xiao ^{c, *,}

a.
Department of Neurology, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China
b.
Liaoning & Shenyang Key Laboratory of Functional Dye and Pigment, Shenyang University of Chemical Technology, Shenyang 110142, China
c.
Department of Ion Channel Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, China

xdjiang@syuct.edu.cn

xhsun@cmu.edu.cn

qinghuanxiao12345@163.com

Received Date: 21 July 2024
Revised Date: 12 September 2024
Accepted Date: 13 September 2024
Available Online: 14 September 2024

Figures(6)

Therapy-induced modulation of the tumor microenvironment (TME) to overcome the immunosuppressive TME is considered to be a chance for cancer treatment. Herein, we prepared near-infrared absorbing aza-BODIPY PhEt-azaBDP with 1-phenylethyl group at 1, 7-sites, a type I photodynamic-photothermal therapy (PDT-PTT) agent. Self-assembly PhEt-azaBDP nanoparticles (NPs) can provide combined phototherapeutic effects under light irradiation and simultaneously induce inflammatory TME, by monitoring tumor-associated macrophages (TAMs) repolarization. Utilizing cluster of differentiation 86 (CD86) and CD163 as the M1-type marker and M2-type marker respectively, PhEt-azaBDP NPs resulted in the increasement of the expression of CD86 and the decreasement of the expression of CD163 in TAMs under near-infrared (NIR) light irradiation, promoting TAMs to switch from M2-phenotype to M1-phenotype. Inflammatory cytokines, interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α), could be the key cytokine involved in the phototherapy-induced TME reprogramming. PhEt-azaBDP NPs could be a potential theranostic scaffold for the simultaneous induction and detection of TME reprogramming triggered by phototherapy.
- Aza-BDOIPY,
- Phototherapy,
- Tumor microenvironment,
- Macrophage,
- Inflammatory cytokine
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沈阳化工大学材料科学与工程学院沈阳 110142