Citation: Li Li, Lin-Lin Zhang, Yansha Gao, Lu-Ying Duan, Wuying Yang, Xigen Huang, Yanping Hong, Jiaxin Hong, Lin Yuan, Limin Lu. Target self-calibration ratiometric fluorescent sensor based on facile-synthesized europium metal-organic framework for multi-color visual detection of levofloxacin[J]. Chinese Chemical Letters, ;2025, 36(7): 110436. doi: 10.1016/j.cclet.2024.110436 shu

Target self-calibration ratiometric fluorescent sensor based on facile-synthesized europium metal-organic framework for multi-color visual detection of levofloxacin

Li Li ^{a, b} ,
Lin-Lin Zhang ^a ,
Yansha Gao ^a ,
Lu-Ying Duan ^{a, *,} ,
Wuying Yang ^a ,
Xigen Huang ^a ,
Yanping Hong ^a ,
Jiaxin Hong ^a ,
Lin Yuan ^{b, *,} ,
Limin Lu ^{a, b, *,}

a.
Key Laboratory of Crop Physiology, Ecology and Genetic Breeding, Ministry of Education, Key Laboratory of Chemical Utilization of Plant Resources of Nanchang, College of Chemistry and Materials, College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang 330045, China
b.
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China

luyingduan@jxau.edu.cn

lyuan@hnu.edu.cn

lulimin816@hotmail.com

Received Date: 11 July 2024
Revised Date: 4 September 2024
Accepted Date: 9 September 2024
Available Online: 12 September 2024

Figures(5)

Developing an accurate and visual sensing strategy for trace levels of fluoroquinolone residues that pose threat to food safety and human health is highly desired but remains challenging. Herein, a target self-calibration ratiometric fluorescent sensing platform has been designed for sensitive visual detection of levofloxacin (LEV) based on fluorescent europium metal-organic framework (Eu-MOF) probe. Specifically, the Eu-MOF was facilely synthesized via directly mixing Eu³⁺ with 1,10-phenanthroline-2,9-dicarboxylic acid (PDA) ligand at room temperature, which exhibited well-stable red fluorescence at 612 nm. Upon the addition of target LEV, the significant fluorescence quenching from Eu³⁺ was observed owing to the inner filter effect between the Eu-MOF and LEV. While the intrinsic fluorescence for LEV at 462 nm was gradually enhanced, thereby realizing the self-calibration ratiometric fluorescence responses to LEV. Through this strategy, LEV can be detected down to 27 nmol/L. Furthermore, a test paper-based Eu-MOF integrated with the smartphone assisted RGB color analysis was exploited for the quantitative monitoring of LEV through the multi-color changes from red to blue, thus achieved portable, convenient and visual detection of LEV in honey and milk samples. Therefore, the developed strategy could provide a useful tool for supporting the practical on-site test in food samples.
- Target self-calibration,
- Ratiometric fluorescence,
- Europium metal-organic Framework,
- Multi-color visual detection,
- Levofloxacin
1. [1]
  X. Van Doorslaer, J. Dewulf, H. Van Langenhove, et al., Sci. Total Environ. 500-501 (2014) 250–269.
2. [2]
  F. Meng, S. Sun, J. Geng, et al., J. Hazard. Mater. 453 (2023) 131322.
3. [3]
  J. Sun, X.P. Liao, A.W. D’Souza, et al., Nat. Commun. 11 (2020) 1427.
4. [4]
  E.S. Orman, H.S. Conjeevaram, R. Vuppalanchi, et al., Clin. Gastroenterol. Hepatol. 9 (2011) 517–523.
5. [5]
  P. Kovalakova, L. Cizmas, T.J. McDonald, et al., Chemosphere 251 (2020) 126351.
6. [6]
  M.K. Jin, Q. Zhang, W.L. Zhao, et al., J. Hazard. Mater. 424 (2022) 127509.
7. [7]
  C. Aymard, H. Kanso, M.J. Serrano, et al., Food Chem. 370 (2022) 131016.
8. [8]
  R. Jiang, D. Lin, Q. Zhang, et al., Sensor. Actuat. B: Chem. 350 (2022) 130902.
9. [9]
  M.D.C. Gómez-Regalado, L. Espín-Moreno, L. Martín-Pozo, et al., Talanta 262 (2023) 124678.
10. [10]
  L. Sun, Y. Chen, Y. Duan, et al., ACS Appl. Mater. Interfaces 13 (2021) 38923–38930. doi: 10.1021/acsami.1c11949
11. [11]
  J. Xiao, L. Qin, D. Zhao, et al., J. Hazard. Mater. 465 (2024) 133221.
12. [12]
  N. Duan, Y. Chang, T. Su, et al., Biosens. Bioelectron. 249 (2024) 116022.
13. [13]
  X. Zhang, F. Yang, T. Ren, et al., Chin. Chem. Lett. 34 (2023) 107835.
14. [14]
  J. Wang, D. Li, Y. Ye, et al., Adv. Mater. 33 (2021) 2008020.
15. [15]
  C. Wang, F. Qin, S. Tang, et al., Food Chem. 411 (2023) 135514.
16. [16]
  V. Arul, N. Sampathkumar, S. Kotteeswaran, et al., Microchim. Acta 190 (2023) 242.
17. [17]
  S. Xu, L. Li, D. Lin, et al., Chin. Chem. Lett. 34 (2023) 107997.
18. [18]
  T. Garg, J.Kaur Renu, et al., Chem. Eng. J. 443 (2022) 136441.
19. [19]
  N. Ding, B. Chen, L. Zhou, et al., Chin. Chem. Lett. 33 (2022) 3797–3801.
20. [20]
  Q. Ouyang, M. Zhang, B. Wang, et al., J. Agric. Food Chem. 71 (2023) 13114–13123. doi: 10.1021/acs.jafc.3c01578
21. [21]
  X. Wang, K. Gopalsamy, G. Clavier, et al., Chem. Sci. 15 (2024) 6488–6499. doi: 10.1039/d3sc06899d
22. [22]
  Y. Zhao, J. Li, Y. Shi, et al., Chin. Chem. Lett. 36 (2025) 110132. doi: 10.1016/j.cclet.2024.110132
23. [23]
  Z.W. Huang, X.B. Li, L. Mei, et al., Adv. Funct. Mater. 34 (2024) 2404126. doi: 10.1002/adfm.202404126
24. [24]
  L. Li, L.L. Zhang, J. Zou, et al., Anal. Chim. Acta 1290 (2024) 342022.
25. [25]
  X. Zhou, X. Wang, L. Shang, Chin. Chem. Lett. 34 (2023) 108093.
26. [26]
  B. Wang, B. Yan, Talanta 208 (2020) 120438.
27. [27]
  J. Chen, Y. Jin, T. Ren, et al., Food Chem. 386 (2022) 132751.
28. [28]
  Z. Zhou, X. Wen, C. Shi, et al., Food Chem. 417 (2023) 135883.
29. [29]
  L. Jiang, T. Chen, E. Song, et al., Chem. Eng. J. 427 (2022) 131563.
30. [30]
  H. Ye, S. Koo, B. Zhu, et al., Anal. Chem. 94 (2022) 15423–15432. doi: 10.1021/acs.analchem.2c03326
31. [31]
  X. Yu, A.A. Ryadun, D.I. Pavlov, et al., Angew. Chem. Int. Ed. 62 (2023) e202306680.
32. [32]
  Y. Wu, Y. Zhou, H. Long, et al., Food Chem. 422 (2023) 136250.
33. [33]
  W. Shi, S. Zhang, Y. Wang, et al., Sensor. Actuat. B: Chem. 367 (2022) 132008.
34. [34]
  H. Dong, S. Liu, Q. Liu, et al., Anal. Chem. 94 (2022) 12852–12859. doi: 10.1021/acs.analchem.2c02852
35. [35]
  J. Song, B. Zhao, Y. Wang, et al., Food Chem. 437 (2024) 137008.
1. [1]
  Ren Shen , Yanmei Fang , Chunxiao Yang , Quande Wei , Pui-In Mak , Rui P. Martins , Yanwei Jia . UV-assisted ratiometric fluorescence sensor for one-pot visual detection of Salmonella. Chinese Chemical Letters, 2025, 36(4): 110143-. doi: 10.1016/j.cclet.2024.110143
2. [2]
  Tiancong Shi , Xi Chen , Xiao Zhou , Hongyi Zhang , Fuping Han , Lihan Cai , Wen Sun , Jianjun Du , Jiangli Fan , Xiaojun Peng . Azaindole-based asymmetric pentamethine cyanine dye for mitochondrial pH detection and near-infrared ratiometric fluorescence imaging of mitophagy. Chinese Chemical Letters, 2025, 36(6): 110408-. doi: 10.1016/j.cclet.2024.110408
3. [3]
  Meirong HAN , Xiaoyang WEI , Sisi FENG , Yuting BAI . A zinc-based metal-organic framework for fluorescence detection of trace Cu²⁺. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1603-1614. doi: 10.11862/CJIC.20240150
4. [4]
  Xiangshuai Li , Jian Zhao , Li Luo , Zhuohao Jiao , Ying Shi , Shengli Hou , Bin Zhao . Visual and portable detection of metronidazole realized by metal-organic framework flexible sensor and smartphone scanning. Chinese Chemical Letters, 2024, 35(10): 109407-. doi: 10.1016/j.cclet.2023.109407
5. [5]
  Ruikui YAN , Xiaoli CHEN , Miao CAI , Jing REN , Huali CUI , Hua YANG , Jijiang WANG . Design, synthesis, and fluorescence sensing performance of highly sensitive and multi-response lanthanide metal-organic frameworks. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 834-848. doi: 10.11862/CJIC.20230301
6. [6]
  Xin Chen , Meng Zhao , Yan-Yuan Jia . Stable Eu(III)-based metal-organic framework for fluorescence sensing of benzaldehyde and its analogues. Chinese Journal of Structural Chemistry, 2025, 44(3): 100445-100445. doi: 10.1016/j.cjsc.2024.100445
7. [7]
  Zhiqiang Liu , Qiang Gao , Wei Shen , Meifeng Xu , Yunxin Li , Weilin Hou , Hai-Wei Shi , Yaozuo Yuan , Erwin Adams , Hian Kee Lee , Sheng Tang . Removal and fluorescence detection of antibiotics from wastewater by layered double oxides/metal-organic frameworks with different topological configurations. Chinese Chemical Letters, 2024, 35(8): 109338-. doi: 10.1016/j.cclet.2023.109338
8. [8]
  Min Liu , Bin Feng , Feiyi Chu , Duoyang Fan , Fan Zheng , Fei Chen , Wenbin Zeng . An ESIPT-boosted NIR nanoprobe for ratiometric sensing of carbon monoxide via activatable aggregation-induced dual-color fluorescence. Chinese Chemical Letters, 2025, 36(5): 110043-. doi: 10.1016/j.cclet.2024.110043
9. [9]
  Menglan Wei , Xiaoxia Ou , Yimeng Wang , Mengyuan Zhang , Fei Teng , Kaixuan Wang . S-scheme heterojunction g-C₃N₄/Bi₂WO₆ highly efficient degradation of levofloxacin: performance, mechanism and degradation pathway. Acta Physico-Chimica Sinica, 2025, 41(9): 100105-0. doi: 10.1016/j.actphy.2025.100105
10. [10]
  Yijian Zhao , Jvzhe Li , Yunyi Shi , Jie Hu , Meiyi Liu , Yao Shen , Xinglin Hou , Qiuyue Wang , Qi Wang , Zhiyi Yao . A label-free and ratiometric fluorescent sensor based on porphyrin-metal-organic frameworks for sensitive detection of ochratoxin A in cereal. Chinese Chemical Letters, 2025, 36(4): 110132-. doi: 10.1016/j.cclet.2024.110132
11. [11]
  Jie ZHANG , Xin LIU , Zhixin LI , Yuting PEI , Yuqi YANG , Huimin LI , Zhiqiang LIU . Assembling a luminescence silencing system based on post-synthetic modification strategy: A highly sensitive and selective turn-on metal-organic framework probe for ascorbic acid detection. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 823-833. doi: 10.11862/CJIC.20230310
12. [12]
  Ziyi Zhu , Yang Cao , Jun Zhang . CO2-switched porous metal-organic framework magnets. Chinese Journal of Structural Chemistry, 2024, 43(2): 100241-100241. doi: 10.1016/j.cjsc.2024.100241
13. [13]
  Muhammad Riaz , Rakesh Kumar Gupta , Di Sun , Mohammad Azam , Ping Cui . Selective adsorption of organic dyes and iodine by a two-dimensional cobalt(II) metal-organic framework. Chinese Journal of Structural Chemistry, 2024, 43(12): 100427-100427. doi: 10.1016/j.cjsc.2024.100427
14. [14]
  Shengyi Gong , Guoqiang Feng . Visible light-triggered NIR ratiometric fluorescent metal-free CO-releasing molecule for self-monitoring of CO delivery and effective cancer therapy. Chinese Chemical Letters, 2025, 36(7): 110409-. doi: 10.1016/j.cclet.2024.110409
15. [15]
  Meiling Xu , Xinyang Li , Pengyuan Liu , Junjun Liu , Xiao Han , Guodong Chai , Shuangling Zhong , Bai Yang , Liying Cui . A novel and visible ratiometric fluorescence determination of carbaryl based on red emissive carbon dots by a solvent-free method. Chinese Chemical Letters, 2025, 36(2): 109860-. doi: 10.1016/j.cclet.2024.109860
16. [16]
  Zhoupeng Zheng , Shengyi Gong , Qianhua Li , Shiya Zhang , Guoqiang Feng . Lipid droplets and gallbladder targeted fluorescence probe for ratiometric NO imaging in gallstones disease models. Chinese Chemical Letters, 2025, 36(5): 110191-. doi: 10.1016/j.cclet.2024.110191
17. [17]
  Xuying Yu , Jiarong Mi , Yulan Han , Cai Sun , Mingsheng Wang , Guocong Guo . A stable radiochromic semiconductive viologen-based metal–organic framework for dual-mode direct X-ray detection. Chinese Chemical Letters, 2024, 35(9): 109233-. doi: 10.1016/j.cclet.2023.109233
18. [18]
  Huan ZHANG , Jijiang WANG , Guang FAN , Long TANG , Erlin YUE , Chao BAI , Xiao WANG , Yuqi ZHANG . A highly stable cadmium(Ⅱ) metal-organic framework for detecting tetracycline and p-nitrophenol. Chinese Journal of Inorganic Chemistry, 2024, 40(3): 646-654. doi: 10.11862/CJIC.20230291
19. [19]
  Wenbiao Zhang , Bolong Yang , Zhonghua Xiang . Atomically dispersed Cu-based metal-organic framework directly for alkaline polymer electrolyte fuel cells. Chinese Chemical Letters, 2025, 36(2): 109630-. doi: 10.1016/j.cclet.2024.109630
20. [20]
  Tengjia Ni , Xianbiao Hou , Huanlei Wang , Lei Chu , Shuixing Dai , Minghua Huang . Controllable defect engineering based on cobalt metal-organic framework for boosting oxygen evolution reaction. Chinese Journal of Structural Chemistry, 2024, 43(1): 100210-100210. doi: 10.1016/j.cjsc.2023.100210

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(3)
HTML views(1)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142