Citation: Xia-Lin Dai, Yu-Hang Yao, Jian-Feng Zhen, Wei Gao, Jia-Mei Chen, Tong-Bu Lu. Reaction crystallization method based on deep eutectic solvents: A novel, green and efficient cocrystal synthesis approach[J]. Chinese Chemical Letters, ;2025, 36(11): 110413. doi: 10.1016/j.cclet.2024.110413 shu

Reaction crystallization method based on deep eutectic solvents: A novel, green and efficient cocrystal synthesis approach

Xia-Lin Dai ^a ,
Yu-Hang Yao ^a ,
Jian-Feng Zhen ^b ,
Wei Gao ^c ,
Jia-Mei Chen ^{a, *,} ,
Tong-Bu Lu ^{b, *,}

a.
School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, China
b.
Institute for New Energy Materials and Low Carbon Technologies, School of Materials Science and Engineering, Tianjin University of Technology, Tianjin 300384, China
c.
School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China

chenjiamei@email.tjut.edu.cn

lutongbu@tjut.edu.cn

Received Date: 24 July 2024
Revised Date: 23 August 2024
Accepted Date: 5 September 2024
Available Online: 6 September 2024

Figures(2)

Reaction crystallization method is a common cocrystal synthesis approach attributed to the advantage of avoiding individual crystallization of insoluble components, but faces the defects of soluble components precipitated due to organic solvent volatilization and the formation of unwanted solvates. Our group recently proposed a slurry method based on deep eutectic solvents (DESs) for cocrystal synthesis, which is green, safe and can avoid solvate formation. However, some reactions only produce insoluble raw materials rather than cocrystals due to insufficient activity of the soluble cocrystal co-formers in DESs. Herein, combining the dual benefits of the two methods, a novel reaction crystallization method based on DESs was proposed and employed for cocrystal synthesis of nicotinamide, carbamazepine and theophylline, which can prevent individual crystallization, unwanted solvate formation, and soluble component precipitation, providing a promising alternative for green and efficient synthesis of cocrystals.
- Cocrystal,
- Deep eutectic solvent,
- Green synthesis,
- Choline,
- Reaction crystallization
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