Citation: Yixin Sun, Keke Yu, Xiuchun Guo, Lanlan Zong, Zhonggui He, Xiaohui Pu. Three-in-one reduction and acid-ignited micelles amplify antitumor efficacy via precise synergistic delivery of paclitaxel and naringenin[J]. Chinese Chemical Letters, ;2025, 36(6): 110393. doi: 10.1016/j.cclet.2024.110393 shu

Three-in-one reduction and acid-ignited micelles amplify antitumor efficacy via precise synergistic delivery of paclitaxel and naringenin

Yixin Sun ^{a, b} ,
Keke Yu ^a ,
Xiuchun Guo ^a ,
Lanlan Zong ^{a, c, *,} ,
Zhonggui He ^{a, b, *,} ,
Xiaohui Pu ^{a, c, *,}

a.
State Key Laboratory of Antiviral Drugs, Henan Province Engineering Research Center of High Value Utilization to Natural Medical Resource in Yellow River Basin, School of Pharmacy, Henan University, Kaifeng 475004, China
b.
Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China
c.
Huaihe Hospital of Henan University, Kaifeng 475004, China

lanlan198903@126.com

hezhgui_student@aliyun.com

pgh425@163.com

Received Date: 7 June 2024
Revised Date: 29 August 2024
Accepted Date: 30 August 2024
Available Online: 31 August 2024

Figures(5)

Chemotherapy is the cornerstone of cancer treatment, and paclitaxel (PTX), as a first-line broad-spectrum chemotherapy drug, is widely used in the treatment of multiple tumors in the clinic. However, unsatisfactory efficacy and drug resistance of single chemotherapy have severely hampered the clinical progress of PTX. Herein, three-in-one naringenin (NAR)-loaded PTX polymer prodrug micelles were constructed for efficient and synergistic antitumor therapy. Firstly, the polymer prodrug micelles could simultaneously act as nanoreservoirs for two hydrophobic drugs, PTX and NAR. Secondly, the polymer prodrug micelles enabled dual-responsive intelligent release of PTX and NAR triggered by reduction and acid. Finally, released PTX and NAR exerted synergistic antitumor effects for reversing tumor resistance, while NAR enhanced the immune and anti-inflammatory functions of polymer prodrug micelles. Due to the cascade-enhanced chemotherapeutic augmentation, the intelligent-responsive nanoreservoir proved to be an excellent antitumor therapeutic platform. This work was of great interest for designing superior chemotherapeutic augmentation regimens.
- Polymer prodrug micelles,
- Synergistic delivery,
- PTX,
- NAR,
- Cancer therapy
1. [1]
  R.L. Siegel, A.N. Giaquinto, A. Jemal, CA Cancer J. Clin. 74 (2024) 12–49. doi: 10.3322/caac.21820
2. [2]
  Nat. Cancer 2 (2021) 245–246.
3. [3]
  J. Zhang, Y. Zhang, Y. Huang, et al., Chem. Eng. J. 458 (2023) 141510. doi: 10.1016/j.cej.2023.141510
4. [4]
  Y. Tong, M. Gu, X. Luo, et al., J. Control. Release 363 (2023) 562–573. doi: 10.1016/j.jconrel.2023.10.005
5. [5]
  A.M. Sofias, M. Dunne, G. Storm, et al., Adv. Drug Deliv. Rev. 122 (2017) 20–30. doi: 10.1016/j.addr.2017.02.003
6. [6]
  S. Guo, M. Vieweger, K. Zhang, et al., Nat. Commun. 11 (2020) 972. doi: 10.1038/s41467-020-14780-5
7. [7]
  Y. Sun, S. Wang, Y. Li, et al., Acta Biomater. 157 (2023) 417–427. doi: 10.1016/j.actbio.2022.12.005
8. [8]
  T. Lammers, Adv. Mater. 36 (2024) 2312169. doi: 10.1002/adma.202312169
9. [9]
  X. Zheng, X. Song, G. Zhu, et al., Adv. Mater. 36 (2024) 2308977. doi: 10.1002/adma.202308977
10. [10]
  W. Jin, Z. Chen, Y. Wang, et al., Chin. Chem. Lett. 35 (2024) 109328. doi: 10.1016/j.cclet.2023.109328
11. [11]
  J. Huang, R. Kong, Y. Li, et al., Chin. Chem. Lett. 35 (2024) 109254. doi: 10.1016/j.cclet.2023.109254
12. [12]
  H. Zubair, M.A. Khan, S. Anand, et al., Semin. Cancer Biol. 80 (2022) 237–255. doi: 10.1016/j.semcancer.2020.05.009
13. [13]
  M. Motallebi, M. Bhia, H.F. Rajani, et al., Life Sci. 305 (2022) 120752. doi: 10.1016/j.lfs.2022.120752
14. [14]
  M. Amelimojarad, M. Amelimojarad, J. Wang, et al., Gene Rep. 26 (2022) 101532. doi: 10.1016/j.genrep.2022.101532
15. [15]
  J. Cai, H. Wen, H. Zhou, et al., Biomed. Pharmacother. 164 (2023) 114990. doi: 10.1016/j.biopha.2023.114990
16. [16]
  H. Zhang, Y. Li, J. Drug Deliv. Sci. Tec. 93 (2024) 105432. doi: 10.1016/j.jddst.2024.105432
17. [17]
  W. Zeng, L. Jin, F. Zhang, et al., Pharmacol. Res. 135 (2018) 122–126. doi: 10.1016/j.phrs.2018.08.002
18. [18]
  R.L. Mianhong Chen, Y.Y. Gao, Y.Y. Zheng, et al., Foods 10 (2021) 963. doi: 10.3390/foods10050963
19. [19]
  L.L. Haidar, M. Bilek, B. Akhavan, Small 20 (2024) 2310876. doi: 10.1002/smll.202310876
20. [20]
  Q. Zou, J. Huang, X. Zhang, Small 14 (2018) 1803101. doi: 10.1002/smll.201803101
21. [21]
  A. Pitchaimani, T.D.T. Nguyen, R. Marasini, et al., Adv. Funct. Mater. 29 (2019) 1806817. doi: 10.1002/adfm.201806817
22. [22]
  P. Kanjilal, K. Dutta, S. Thayumanavan, Angew. Chem. Int. Ed. 61 (2022) e202209227. doi: 10.1002/anie.202209227
23. [23]
  Z. Qin, Y. Yang, Q. Tian, et al., Chem. Eng. J. 467 (2023) 143434. doi: 10.1016/j.cej.2023.143434
24. [24]
  Y. Qin, M. Huang, C. Huang, et al., Chin. Chem. Lett. 35 (2024) 109171. doi: 10.1016/j.cclet.2023.109171
25. [25]
  Y. Tao, C. Dai, Z. Xie, et al., Chin. Chem. Lett. 35 (2024) 109170. doi: 10.1016/j.cclet.2023.109170
26. [26]
  B. Sun, C. Luo, X. Zhang, et al., Nat. Commun. 10 (2019) 3211. doi: 10.1038/s41467-019-11193-x
27. [27]
  S. Zheng, G. Li, S. Fu, et al., Chem. Eng. J. 479 (2024) 147802. doi: 10.1016/j.cej.2023.147802
28. [28]
  H. Xu, S. Zuo, D. Wang, et al., J. Control. Release 360 (2023) 784–795. doi: 10.1016/j.jconrel.2023.07.012
29. [29]
  J. Du, L. Zong, M. Li, et al., Int. J. Nanomedicine 17 (2022) 1323–1341. doi: 10.2147/ijn.s348598
1. [1]
  Yuanyi Zhou , Ke Ma , Jinfeng Liu , Zirun Zheng , Bo Hu , Yu Meng , Zhizhong Li , Mingshan Zhu . Is reactive oxygen species the only way for cancer inhibition over single atom nanomedicine? Autophagy regulation also works. Chinese Chemical Letters, 2024, 35(6): 109056-. doi: 10.1016/j.cclet.2023.109056
2. [2]
  Ziqin Li , Kai Hao , Longwei Xiang , Huayu Tian . Cationic covalent organic framework nanocarriers integrating both efficient gene silencing and real-time gene detection. Chinese Chemical Letters, 2025, 36(4): 109943-. doi: 10.1016/j.cclet.2024.109943
3. [3]
  Li Fu , Ziye Su , Shuyang Wu , Yanfen Cheng , Chuan Hu , Jinming Zhang . Redox-responsive hyaluronic acid-celastrol prodrug micelles with glycyrrhetinic acid co-delivery for tumor combination therapy. Chinese Chemical Letters, 2025, 36(5): 110227-. doi: 10.1016/j.cclet.2024.110227
4. [4]
  Wenjia Wang , Xingyue He , Xiaojie Wang , Tiantian Zhao , Osamu Muraoka , Genzoh Tanabe , Weijia Xie , Tianjiao Zhou , Lei Xing , Qingri Jin , Hulin Jiang . Glutathione-depleted cyclodextrin pseudo-polyrotaxane nanoparticles for anti-inflammatory oxaliplatin (Ⅳ) prodrug delivery and enhanced colorectal cancer therapy. Chinese Chemical Letters, 2024, 35(4): 108656-. doi: 10.1016/j.cclet.2023.108656
5. [5]
  Huijie An , Chen Yang , Zhihui Jiang , Junjie Yuan , Zhongming Qiu , Longhao Chen , Xin Chen , Mutu Huang , Linlang Huang , Hongju Lin , Biao Cheng , Hongjiang Liu , Zhiqiang Yu . Luminescence-activated Pt(Ⅳ) prodrug for in situ triggerable cancer therapy. Chinese Chemical Letters, 2024, 35(7): 109134-. doi: 10.1016/j.cclet.2023.109134
6. [6]
  Mengjuan Sun , Muye Zhou , Yifang Xiao , Hailei Tang , Jinhua Chen , Ruitao Zhang , Chunjiayu Li , Qi Ya , Qian Chen , Jiasheng Tu , Qiyue Wang , Chunmeng Sun . Reversibly size-switchable polyion complex micelles for antiangiogenic cancer therapy. Chinese Chemical Letters, 2024, 35(7): 109110-. doi: 10.1016/j.cclet.2023.109110
7. [7]
  Lin Li , Bingjun Sun , Jin Sun , Lin Chen , Zhonggui He . Binary prodrug nanoassemblies combining chemotherapy and ferroptosis activation for efficient triple-negative breast cancer therapy. Chinese Chemical Letters, 2024, 35(10): 109538-. doi: 10.1016/j.cclet.2024.109538
8. [8]
  Qiang Li , Jiangbo Fan , Hongkai Mu , Lin Chen , Yongzhen Yang , Shiping Yu . Nucleus-targeting orange-emissive carbon dots delivery adriamycin for enhanced anti-liver cancer therapy. Chinese Chemical Letters, 2024, 35(6): 108947-. doi: 10.1016/j.cclet.2023.108947
9. [9]
  Yihan Zhou , Duo Gao , Yaying Wang , Li Liang , Qingyu Zhang , Wenwen Han , Jie Wang , Chunliu Zhu , Xinxin Zhang , Yong Gan . Worm-like micelles facilitate the intestinal mucus diffusion and drug accumulation for enhancing colorectal cancer therapy. Chinese Chemical Letters, 2024, 35(6): 108967-. doi: 10.1016/j.cclet.2023.108967
10. [10]
  Boyuan Liu , Zixu Liu , Ping Wang , Yu Zhang , Haibing He , Tian Yin , Jingxin Gou , Xing Tang . Nanomedicine-based targeting delivery systems for peritoneal cavity localized therapy: A promising treatment of ovarian cancer and its peritoneal metastasis. Chinese Chemical Letters, 2025, 36(6): 110229-. doi: 10.1016/j.cclet.2024.110229
11. [11]
  Xuejian Xing , Pan Zhu , E Pang , Shaojing Zhao , Yu Tang , Zheyu Hu , Quchang Ouyang , Minhuan Lan . D-A-D-structured boron-dipyrromethene with aggregation-induced enhanced phototherapeutic efficiency for near-infrared fluorescent and photoacoustic imaging-guided synergistic photodynamic and photothermal cancer therapy. Chinese Chemical Letters, 2024, 35(10): 109452-. doi: 10.1016/j.cclet.2023.109452
12. [12]
  Bing Xie , Qi Jiang , Fang Zhu , Yaoyao Lai , Yueming Zhao , Wei He , Pei Yang . Transdermal delivery of amphotericin B using deep eutectic solvents for antifungal therapy. Chinese Chemical Letters, 2025, 36(5): 110508-. doi: 10.1016/j.cclet.2024.110508
13. [13]
  Xiangqian Cao , Chenkai Yang , Xiaodong Zhu , Mengxin Zhao , Yilin Yan , Zhengnan Huang , Jinming Cai , Jingming Zhuang , Shengzhou Li , Wei Li , Bing Shen . Synergistic enhancement of chemotherapy for bladder cancer by photothermal dual-sensitive nanosystem with gold nanoparticles and PNIPAM. Chinese Chemical Letters, 2024, 35(8): 109199-. doi: 10.1016/j.cclet.2023.109199
14. [14]
  Xiaofang Luo , Ye Wu , Xiaokun Zhang , Min Tang , Feiye Ju , Zuodong Qin , Gregory J Duns , Wei-Dong Zhang , Jiang-Jiang Qin , Xin Luan . Peptide-based strategies for overcoming multidrug-resistance in cancer therapy. Chinese Chemical Letters, 2025, 36(1): 109724-. doi: 10.1016/j.cclet.2024.109724
15. [15]
  Zhendong Liu , Sainan Liu , Bin Liu , Qi Meng , Meng Yuan , Chunzheng Yang , Yulong Bian , Ping'an Ma , Jun Lin . Fe(Ⅲ)-juglone nanoscale coordination polymers for cascade chemodynamic therapy through synergistic ferroptosis and apoptosis strategy. Chinese Chemical Letters, 2024, 35(11): 109626-. doi: 10.1016/j.cclet.2024.109626
16. [16]
  Du Liu , Yuyan Li , Hankun Zhang , Benhua Wang , Chaoyi Yao , Minhuan Lan , Zhanhong Yang , Xiangzhi Song . Three-in-one erlotinib-modified NIR photosensitizer for fluorescence imaging and synergistic chemo-photodynamic therapy. Chinese Chemical Letters, 2025, 36(2): 109910-. doi: 10.1016/j.cclet.2024.109910
17. [17]
  Yu-Hui Zhang , Ye Tian , Xianliang Sheng , Chen-Shuang Liu , Lu-Qiang Wei , Jie Wang , Yong Chen . Construction of a black phosphorous-based noncovalent multiple nanosupramolecular assembly for synergistic targeted photothermal and chemodynamic therapy. Chinese Chemical Letters, 2025, 36(4): 110193-. doi: 10.1016/j.cclet.2024.110193
18. [18]
  Xin Li , Xuan Ding , Junkun Zhou , Hui Shi , Zhenxi Dai , Jiayi Liu , Yongcun Ma , Penghui Shao , Liming Yang , Xubiao Luo . Utilizing synergistic effects of bifunctional polymer hydrogel PAM-PAMPS for selective capture of Pb(Ⅱ) from wastewater. Chinese Chemical Letters, 2024, 35(7): 109158-. doi: 10.1016/j.cclet.2023.109158
19. [19]
  Hao Sun , Shengke Li , Qian Liu , Minzan Zuo , Xueqi Tian , Kaiya Wang , Xiao-Yu Hu . Supramolecular prodrug vesicles for selective antimicrobial therapy employing a chemo-photodynamic strategy. Chinese Chemical Letters, 2025, 36(3): 109999-. doi: 10.1016/j.cclet.2024.109999
20. [20]
  Ningyue Xu , Jun Wang , Lei Liu , Changyang Gong . Injectable hydrogel-based drug delivery systems for enhancing the efficacy of radiation therapy: A review of recent advances. Chinese Chemical Letters, 2024, 35(8): 109225-. doi: 10.1016/j.cclet.2023.109225

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(159)
HTML views(4)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142