Citation: Haoran Hou, Siwen Wei, Yutong Shao, Yingnan Wu, Gaobo Hong, Jing An, Jiarui Tian, Jianjun Du, Fengling Song, Xiaojun Peng. A 690-nm-excitable type Ⅰ & Ⅱ photosensitizer based on biotinylation of verteporfin for photodynamic therapy of deep-seated orthotopic breast tumors[J]. Chinese Chemical Letters, ;2025, 36(6): 110315. doi: 10.1016/j.cclet.2024.110315 shu

A 690-nm-excitable type Ⅰ & Ⅱ photosensitizer based on biotinylation of verteporfin for photodynamic therapy of deep-seated orthotopic breast tumors

Haoran Hou ^a ,
Siwen Wei ^a ,
Yutong Shao ^b ,
Yingnan Wu ^b ,
Gaobo Hong ^a ,
Jing An ^a ,
Jiarui Tian ^b ,
Jianjun Du ^a ,
Fengling Song ^{b, *,} ,
Xiaojun Peng ^a

a.
State Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Dalian University of Technology, Dalian 116024, China
b.
Institute of Frontier Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Qingdao 266237, China

songfl@dlut.edu.cn

Received Date: 19 April 2024
Revised Date: 26 July 2024
Accepted Date: 31 July 2024
Available Online: 5 August 2024

Figures(5)

The efficacy of photodynamic therapy (PDT) for breast tumors is hindered by challenges such as inadequate tumor targeting, limited treatment depth, and strong oxygen dependence. Herein, a promising photosensitizer VP-B was developed to simultaneously address all the aforementioned issues for the treatment of hypoxic deep-seated breast tumors. The biotinylated photosensitizer VP-B not only exhibited precise targeting towards breast tumor tissue, but also efficiently triggered the generation of abundant ¹O₂ and O₂^−• under 690 nm red light irradiation. Indeed, the red light penetration ability enabled VP-B to achieve successful application in a mouse orthotopic breast tumor model. After intravenous administration, VP-B can selectively target tumor tissues and significantly inhibit the growth of hypoxic deep-seated tumors. Therefore, this new type Ⅰ & Ⅱ photosensitizer could boost fluorescence-guided photodynamic therapy of other hypoxic solid tumors.
- Photodynamic therapy,
- Orthotopic breast tumor,
- Deep-seated tumor,
- Type Ⅰ PDT,
- Photosensitizers
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