Citation: Cheng Wang, Ji Wang, Dong Liu, Zhi-Ling Zhang. Advances in virus-host interaction research based on microfluidic platforms[J]. Chinese Chemical Letters, ;2024, 35(12): 110302. doi: 10.1016/j.cclet.2024.110302 shu

Advances in virus-host interaction research based on microfluidic platforms

Cheng Wang ^{a, b, 1} ,
Ji Wang ^{b, c, 1} ,
Dong Liu ^{a, *,} ,
Zhi-Ling Zhang ^{b, *,}

a.
School of Life Sciences, Co-Innovation Center of Neuroregeneration, Nantong Laboratory of Development and Diseases, Nantong University, Nantong 226019, China
b.
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China
c.
Centre for Immunology and Infection, Hong Kong Science and Technology Park, Hong Kong SAR 999077, China

tom@ntu.edu.cn

zlzhang@whu.edu.cn

Received Date: 16 March 2024
Revised Date: 28 June 2024
Accepted Date: 29 July 2024
Available Online: 31 July 2024

Figures(6)

Viral epidemics pose a serious threat to global public health, making it essential to explore virus-host interactions for uncovering the pathogenesis of viral diseases and developing effective antiviral strategies. Traditional in vitro cell infection models struggle to replicate physiological microenvironment, while animal infection models may encounter obstacles such as species gap, high-cost, and ethical issues. Additionally, potential heterogeneous infection outcomes are usually inaccessible by population-based experiments. Microfluidics, as an emerging interdisciplinary platform, has proven to be a powerful tool for inquiring virus-host interactions. In this review, conventional virological methods were introduced first and remarkable advantages of microfluidics in viral cell biology were highlighted. Next, the in-depth applications of microfluidics in analyzing heterogeneity of virus-host interplays, dynamic monitoring of events related to viral life cycle, and modeling of viral infectious diseases were fully elaborated from the perspective of single-cell chip, multi-cell culture chip and organ-on-a-chip (organ chip). Finally, the opportunities and challenges in developing robust microfluidic methods for virology were discussed. Overall, this review aims to provide an overview of microfluidic-based research on virus-host interaction and promote multidisciplinary collaborations for better understanding and responding to viral threats.
- Microfluidics,
- Virus-host interaction,
- Cellular microchip,
- Single-cell analysis,
- Organ-on-a-chip,
- Viral infectious disease
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沈阳化工大学材料科学与工程学院沈阳 110142