Citation: Li Li, Jiale Wen, Xiaojun Zhang, Shuwen Fu, Zixuan Chen, Kai Huang, Luyue Fang, Tinghe Zhao, Peipei Zhang, Xingshu Li. A near-infrared naphthalocyanine photosensitizer with superior light absorption and renal clearance for type-Ⅰ photodynamic and photothermal combination therapy[J]. Chinese Chemical Letters, ;2025, 36(6): 110290. doi: 10.1016/j.cclet.2024.110290 shu

A near-infrared naphthalocyanine photosensitizer with superior light absorption and renal clearance for type-Ⅰ photodynamic and photothermal combination therapy

Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou 350108, China

xingshuli@fzu.edu.cn

Received Date: 30 April 2024
Revised Date: 21 July 2024
Accepted Date: 22 July 2024
Available Online: 23 July 2024

Figures(4)

Currently, it is still a challenge to develop an organic photosensitizer (PS) with outstanding near-infrared absorption, low O₂ dependence, precise tumor targeting and rapid clearance through the kidney to improve the overall outcome of phototherapy. In this study, we have designed an organic PS (NcPB) with an excellent near-infrared light absorption through a refined molecular strategy. Meanwhile, NcPB was assembled into nanoparticles with different sizes (NanoNcPB-1 and NanoNcPB-0) by a supramolecular modulation strategy. As the results, the nanoparticle with an ultra-small size (NanoNcPB-1) generated a large number of superoxide anion (O₂^•−) in a low-O₂-dependent manner and release plenty of heat. Furthermore, the results of in vivo experiments demonstrated that NanoNcPB-1 actively accumulated in tumor tissues and showed a 92% tumor inhibition after photodynamic and photothermal combination therapy. More importantly, NanoNcPB-1 could be rapidly cleared from the body of mice via the renal pathway, which alleviates potential side effects of prolonged retention of PS in the circulation.
- Naphthalocyanine,
- Near-infrared absorption,
- Renal clearance,
- Superoxide anion,
- Type-Ⅰ photosensitizer
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