Citation: Hongwei Ding, Jingjing Yang, Yongchen Shuai, Di Wei, Xueliang Liu, Guiying Li, Lin Jin, Jianliang Shen. In situ preparation of tannin-mediated CeO₂@CuS nanocomposites for multimodal wound therapy[J]. Chinese Chemical Letters, ;2025, 36(6): 110286. doi: 10.1016/j.cclet.2024.110286 shu

In situ preparation of tannin-mediated CeO₂@CuS nanocomposites for multimodal wound therapy

Hongwei Ding ^a ,
Jingjing Yang ^b ,
Yongchen Shuai ^b ,
Di Wei ^b ,
Xueliang Liu ^a ,
Guiying Li ^{d, *} ,
Lin Jin ^{a, *} ,
Jianliang Shen ^{c, *}

a.
The Key Laboratory of Rare Earth Functional Materials and Applications, International Joint Research Laboratory for Biomedical Nanomaterials of Henan, Zhoukou Normal University, Zhoukou 466001, China
b.
School of Chemistry and Chemical Engineering, Zhoukou Normal University, Zhoukou 466001, China
c.
Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, China
d.
Affiliated Hospital of Hebei Engineering University, The Key Laboratory of Basic Research on Blood Purification Application in Hebei Province, Handan 056002, China

fflgy@126.com

jinlin_1982@126.com

yongfengwang@pku.edu.cn

Received Date: 11 June 2024
Revised Date: 16 July 2024
Accepted Date: 18 July 2024
Available Online: 19 July 2024

Figures(5)

Bacterial infection, insufficient angiogenesis, and oxidative damage are generally regarded as key issues that impede wound healing, making it necessary to prepare new biomaterials to simultaneously address these problems. In this work, monodispersed CeO₂@CuS nanocomposites (NCs) were successfully prepared with tannin (TA) as the reductant and linker. Due to abundant oxygen vacancies in CeO₂ and the polyphenolic structure of TA, the TA-CeO₂@CuS NCs exhibited a remarkable antioxidant ability to scavenge excessive reactive oxygen species (ROS), which would likely induce serious inflammation. In addition, the TA-CeO₂@CuS NCs demonstrated excellent antibacterial capability with near-infrared ray (NIR) irradiation, and the released copper ions could promote the regeneration of blood vessels. These synergistic effects indicated that the synthesized TA-CeO₂@CuS NCs could serve as a promising biomaterial for multimodal wound therapy.
- Nanocomposites,
- Antibacterial,
- Anti-inflammation,
- Wound therapy,
- Photothermal,
- ROS scavenging
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

In situ preparation of tannin-mediated CeO2@CuS nanocomposites for multimodal wound therapy

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通讯作者: 陈斌, bchen63@163.com

In situ preparation of tannin-mediated CeO₂@CuS nanocomposites for multimodal wound therapy