Citation: Haijun Shen, Yi Qiao, Chun Zhang, Yane Ma, Jialing Chen, Yingying Cao, Wenna Zheng. A matrix metalloproteinase-sensitive hydrogel combined with photothermal therapy for transdermal delivery of deferoxamine to accelerate diabetic pressure ulcer healing[J]. Chinese Chemical Letters, ;2024, 35(12): 110283. doi: 10.1016/j.cclet.2024.110283 shu

A matrix metalloproteinase-sensitive hydrogel combined with photothermal therapy for transdermal delivery of deferoxamine to accelerate diabetic pressure ulcer healing

Department of Preventive Medicine and Public Health Laboratory Science, School of Medicine, Jiangsu University, Zhenjiang 212013, China

shenhj@ujs.edu.cn

Received Date: 13 May 2024
Revised Date: 15 July 2024
Accepted Date: 17 July 2024
Available Online: 18 July 2024

Figures(5)

Diabetic pressure ulcers (DPU) are non-healing due to vascular dysfunction and bacterial infection. Early intervention can delay ulcer progression, such as preventing the formation of full-thickness skin defects. Local administration of deferoxamine (DFO) at wound sites has been shown to promote neovascularization and enhance wound healing. However, since DPU skin wounds are not full-thickness defects and DFO is hydrophilic, enhancing its transdermal delivery is crucial for effective treatment. Photothermal ablation of stratum corneum, generated by copper sulfide nanoparticles (CuS NPs) under near-infrared (NIR) light irradiation, is a promising method to improve transdermal drug delivery. Meanwhile, CuS NPs-induced photothermal therapy offers excellent antibacterial performance. In this study, DFO and CuS NPs were incorporated into a matrix metalloproteinase (MMPs)-sensitive hydrogel. This hydrogel promotes cell adhesion and is degraded by cell-secreted MMPs, a process crucial for the controlled release of encapsulated DFO and CuS NPs. Under NIR irradiation, the stratum corneum is disrupted, facilitating transdermal DFO delivery and simultaneously eliminating infected bacteria. As a result, the essential requirements for DPU treatment, "facilitating transdermal DFO delivery, promoting angiogenesis, and inhibiting bacterial infection", were achieved simultaneously.
- Diabetic pressure ulcer,
- Transdermal drug delivery,
- Matrix metalloproteinase-sensitive hydrogel,
- Antibacterial,
- Angiogenesis
1. [1]
  N.H. Cho, J.E. Shaw, S. Karuranga, et al., Diabetes Res Clin Pract. 138 (2018) 271–281. doi: 10.1016/j.diabres.2018.02.023
2. [2]
  L.E. Edsberg, J.M. Black, M. Goldberg, et al., J. Wound. Ostomy. Cont. 43 (2016) 585-597. doi: 10.1097/WON.0000000000000281
3. [3]
  M.S. Hu, Z.N. Maan, J.C. Wu, et al., Ann. Biomed. Eng. 42 (2014) 1494–1507. doi: 10.1007/s10439-014-1010-z
4. [4]
  J. M. Ramirez-Acuna, S.A. Cardenas-Cadena, P.A. Marquez-Salas, et al., Antibiotics 8 (2019) 193. doi: 10.3390/antibiotics8040193
5. [5]
  H.N. Wilkinson, M.J. Hardman, Open Biol. 10 (2020) 200223. doi: 10.1098/rsob.200223
6. [6]
  V. Falanga, R.R. Isseroff, A.M. Soulika, et al., Nat. Rev. Dis. Primers. 8 (2022) 50. doi: 10.1038/s41572-022-00377-3
7. [7]
  Y.M. Niu, Q. Li, Y. Ding, et al., Adv. Drug Deliv. Rev. 146 (2019) 190–208. doi: 10.1016/j.addr.2018.06.002
8. [8]
  Z.Y. Qian, H.P. Wang, Y.T. Bai, et al., ACS Appl. Mater. Interfaces 12 (2020) 55659–55674. doi: 10.1021/acsami.0c17142
9. [9]
  Z.N. Yi, X.N. Xu, X.H. Meng, et al., Chin. Chem. Lett. 34 (2023) 108238. doi: 10.1016/j.cclet.2023.108238
10. [10]
  R. Zhang, G.H. Jiang, Q.Q. Gao, et al., Nanoscale 13 (2021) 15937–15951. doi: 10.1039/d1nr04687j
11. [11]
  M. Wang, C.G. Wang, M. Chen, et al., ACS Nano 13 (2019) 10279–10293. doi: 10.1021/acsnano.9b03656
12. [12]
  L.Z. Kong, Z. Wu, H.K. Zhao, et al., ACS Appl. Mater. Interfaces 10 (2018) 30103–30114. doi: 10.1021/acsami.8b09191
13. [13]
  J.Z. Zhu, C. Chen, J. Dong, et al., Chin. Chem. Lett. 34 (2023) 107514. doi: 10.1016/j.cclet.2022.05.028
14. [14]
  S. Ramadan, L.R. Guo, Y.J. Li, et al., Small 8 (2012) 3143–3150. doi: 10.1002/smll.201200783
15. [15]
  Z.K. Hu, H.J. Zhang, Z.Q. Li, et al., Chin. Chem. Lett. 35 (2024) 109527. doi: 10.1016/j.cclet.2024.109527
16. [16]
  D. Kupczyk, R. Bilski, R. Studziñska, et al., Postepy. Dermatol. Alergol. 39 (2022) 59–65. doi: 10.5114/ada.2020.100737
17. [17]
  W. Chen, C.Y. Wang, W. Liu, et al., Adv. Mater. 35 (2023) e2209041. doi: 10.1002/adma.202209041
18. [18]
  S.L. Zhu, B.J. Zhao, M.C. Li, et al., Bioact. Mater. 26 (2023) 306–320.
19. [19]
  B.D. Zheng, M.T. Xiao, Carbohydr. Polym. 299 (2023) 120228. doi: 10.1016/j.carbpol.2022.120228
20. [20]
  S. Sharma, V.K. Rai, R.K. Narang, et al., Life Sci. 290 (2022) 120096. doi: 10.1016/j.lfs.2021.120096
1. [1]
  Yueying Wang , Jianming Xiong , Linwei Xin , Yuanyuan Li , He Huang , Wenjun Miao . Photosensitizer-synergized g-carbon nitride nanosheets with enhanced photocatalytic activity for eradicating drug-resistant bacteria and promoting wound healing. Chinese Chemical Letters, 2025, 36(4): 110003-. doi: 10.1016/j.cclet.2024.110003
2. [2]
  Xiaoliu Liang , Chunliu Huang , Hui Liu , Hu Chen , Jiabao Shou , Hongwei Cheng , Gang Liu . Natural hydrogel dressings in wound care: Design, advances, and perspectives. Chinese Chemical Letters, 2024, 35(10): 109442-. doi: 10.1016/j.cclet.2023.109442
3. [3]
  Wen Zhong , Dan Zheng , Xukun Liao , Yadi Zhou , Yan Jiang , Ting Gao , Ming Li , Chengli Yang . Elaborate construction of pH-sensitive polymyxin B loaded nanoparticles for safe and effective treatment of carbapenem-resistant Klebsiella pneumoniae. Chinese Chemical Letters, 2025, 36(3): 110448-. doi: 10.1016/j.cclet.2024.110448
4. [4]
  Yue Ren , Kang Li , Yi-Zi Wang , Shao-Peng Zhao , Shu-Min Pan , Haojie Fu , Mengfan Jing , Yaming Wang , Fengyuan Yang , Chuntai Liu . Swelling and erosion assisted sustained release of tea polyphenol from antibacterial ultrahigh molecular weight polyethylene for joint replacement. Chinese Chemical Letters, 2025, 36(2): 110468-. doi: 10.1016/j.cclet.2024.110468
5. [5]
  Feng Cui , Fangman Chen , Xiaochun Xie , Chenyang Guo , Kai Xiao , Ziping Wu , Yinglu Chen , Junna Lu , Feixia Ruan , Chuanxu Cheng , Chao Yang , Dan Shao . Scalable production of mesoporous titanium nanoparticles through sequential flash nanocomplexation. Chinese Chemical Letters, 2024, 35(4): 108681-. doi: 10.1016/j.cclet.2023.108681
6. [6]
  Ningyue Xu , Jun Wang , Lei Liu , Changyang Gong . Injectable hydrogel-based drug delivery systems for enhancing the efficacy of radiation therapy: A review of recent advances. Chinese Chemical Letters, 2024, 35(8): 109225-. doi: 10.1016/j.cclet.2023.109225
7. [7]
  Jiajia Wang , XinXin Ge , Yajing Xiang , Xiaoliang Qi , Ying Li , Hangbin Xu , Erya Cai , Chaofan Zhang , Yulong Lan , Xiaojing Chen , Yizuo Shi , Zhangping Li , Jianliang Shen . An ionic liquid functionalized sericin hydrogel for drug-resistant bacteria-infected diabetic wound healing. Chinese Chemical Letters, 2025, 36(2): 109819-. doi: 10.1016/j.cclet.2024.109819
8. [8]
  Linghui Zou , Meng Cheng , Kaili Hu , Jianfang Feng , Liangxing Tu . Vesicular drug delivery systems for oral absorption enhancement. Chinese Chemical Letters, 2024, 35(7): 109129-. doi: 10.1016/j.cclet.2023.109129
9. [9]
  Fengjie Liu , Fansu Meng , Zhenjiang Yang , Huan Wang , Yuehong Ren , Yu Cai , Xingwang Zhang . Exosome-biomimetic nanocarriers for oral drug delivery. Chinese Chemical Letters, 2024, 35(9): 109335-. doi: 10.1016/j.cclet.2023.109335
10. [10]
  Dexuan Xiao , Tianyu Chen , Tianxu Zhang , Sirong Shi , Mei Zhang , Xin Qin , Yunkun Liu , Longjiang Li , Yunfeng Lin . Transdermal treatment for malignant melanoma by aptamer-modified tetrahedral framework nucleic acid delivery of vemurafenib. Chinese Chemical Letters, 2024, 35(4): 108602-. doi: 10.1016/j.cclet.2023.108602
11. [11]
  Yujie Li , Ya-Nan Wang , Yin-Gen Luo , Hongcai Yang , Jinrui Ren , Xiao Li . Advances in synthetic biology-based drug delivery systems for disease treatment. Chinese Chemical Letters, 2024, 35(11): 109576-. doi: 10.1016/j.cclet.2024.109576
12. [12]
  Jinjie Lu , Qikai Liu , Yuting Zhang , Yi Zhou , Yanbo Zhou . Antibacterial performance of cationic quaternary phosphonium-modified chitosan polymer in water. Chinese Chemical Letters, 2024, 35(9): 109406-. doi: 10.1016/j.cclet.2023.109406
13. [13]
  Wei Su , Xiaoyan Luo , Peiyuan Li , Ying Zhang , Chenxiang Lin , Kang Wang , Jianzhuang Jiang . Phthalocyanine self-assembled nanoparticles for type Ⅰ photodynamic antibacterial therapy. Chinese Chemical Letters, 2024, 35(12): 109522-. doi: 10.1016/j.cclet.2024.109522
14. [14]
  Qihang Wu , Hui Wen , Wenhai Lin , Tingting Sun , Zhigang Xie . Alkyl chain engineering of boron dipyrromethenes for efficient photodynamic antibacterial treatment. Chinese Chemical Letters, 2024, 35(12): 109692-. doi: 10.1016/j.cclet.2024.109692
15. [15]
  Fangping Yang , Jin Shi , Yuansong Wei , Qing Gao , Jingrui Shen , Lichen Yin , Haoyu Tang . Mixed-charge glycopolypeptides as antibacterial coatings with long-term activity. Chinese Chemical Letters, 2025, 36(2): 109746-. doi: 10.1016/j.cclet.2024.109746
16. [16]
  Chong Liu , Ling Li , Jiahui Gao , Yanwei Li , Nazhen Zhang , Jing Zang , Cong Liu , Zhaopei Guo , Yanhui Li , Huayu Tian . The study of antibacterial activity of cationic poly(β-amino ester) regulating by amphiphilic balance. Chinese Chemical Letters, 2025, 36(2): 110118-. doi: 10.1016/j.cclet.2024.110118
17. [17]
  Zhilong Xie , Guohui Zhang , Ya Meng , Yefei Tong , Jian Deng , Honghui Li , Qingqing Ma , Shisong Han , Wenjun Ni . A natural nano-platform: Advances in drug delivery system with recombinant high-density lipoprotein. Chinese Chemical Letters, 2024, 35(11): 109584-. doi: 10.1016/j.cclet.2024.109584
18. [18]
  Xingyu Chen , Sihui Zhuang , Weiyao Yan , Zhengli Zeng , Jianguo Feng , Hongen Cao , Lei Yu . Synthesis, antibacterial evaluation, and safety assessment of Se@PLA as a potent bactericide against Xanthomonas oryzae pv. oryzae. Chinese Chemical Letters, 2024, 35(10): 109635-. doi: 10.1016/j.cclet.2024.109635
19. [19]
  Chao LIU , Jiang WU , Zhaolei JIN . Synthesis, crystal structures, and antibacterial activities of two zinc(Ⅱ) complexes bearing 5-phenyl-1H-pyrazole group. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1986-1994. doi: 10.11862/CJIC.20240153
20. [20]
  Mianling Yang , Meehyein Kim , Peng Zhan . Modular miniaturized synthesis and in situ biological evaluation facilitate rapid discovery of potent MraY inhibitors as antibacterial agents. Chinese Chemical Letters, 2025, 36(2): 110455-. doi: 10.1016/j.cclet.2024.110455

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沈阳化工大学材料科学与工程学院沈阳 110142