Citation: Mengwei Ye, Qingqing Xu, Huanhuan Jian, Yiduo Ding, Wenpeng Zhao, Chenxiao Wang, Junya Lu, Shuaipeng Feng, Siling Wang, Qinfu Zhao. Recent trends of biodegradable mesoporous silica based nanoplatforms for enhanced tumor theranostics[J]. Chinese Chemical Letters, ;2025, 36(6): 110221. doi: 10.1016/j.cclet.2024.110221 shu

Recent trends of biodegradable mesoporous silica based nanoplatforms for enhanced tumor theranostics

Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China

qinfuzhao@syphu.edu.cn

Received Date: 1 April 2024
Revised Date: 29 June 2024
Accepted Date: 4 July 2024
Available Online: 5 July 2024

Figures(5)

Mesoporous silica nanoparticles (MSNs) are thought to be an attractive drug delivery material because of their advantages including high specific surface area, tunable pore size and morphology, easy surface modification and good biocompatibility. However, as a result of the poor biodegradability of MSNs, their biomedical applications are limited. To break the bottleneck of limited biomedical applications of MSNs, more and more researchers tend to design biodegradable MSNs (b-MSNs) nanosystems to obtain biodegradable as well as safe and reliable drug delivery carriers. In this review, we focused on summarizing strategies to improve the degradability of MSNs and innovatively proposed a series of advantages of b-MSNs, including controlled cargo release behavior, multifunctional frameworks, nano-catalysis, bio-imaging capabilities and enhanced therapeutic effects. Based on these advantages, we have innovatively summarized the applications of b-MSNs for enhanced tumor theranostics, including enhanced chemotherapy, delivery of nanosensitizers, gas molecules and biomacromolecules, initiation of immune response, synergistic therapies and image-guided tumor diagnostics. Finally, the challenges and further clinical translation potential of nanosystems based on b-MSNs are fully discussed and prospected. We believe that such b-MSNs delivery carriers will provide a timely reference for further applications in tumor theranostics.
- Biodegradable mesoporous silica nanoparticles,
- Tumor theranostics,
- Biodegradability,
- Synergistic therapy,
- Controlled release,
- Drug delivery
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