Citation: Xiaoshuai Wu, Bailei Wang, Yichen Li, Xiaoxuan Guan, Mingjing Yin, Wenquan Lv, Yin Chen, Fei Lu, Tao Qin, Huyang Gao, Weiqian Jin, Yifu Huang, Cuiping Li, Ming Gao, Junyu Lu. NIR driven catalytic enhanced acute lung injury therapy by using polydopamine@Co nanozyme via scavenging ROS[J]. Chinese Chemical Letters, ;2025, 36(2): 110211. doi: 10.1016/j.cclet.2024.110211 shu

NIR driven catalytic enhanced acute lung injury therapy by using polydopamine@Co nanozyme via scavenging ROS

Xiaoshuai Wu ^{a, 1} ,
Bailei Wang ^{b, 1} ,
Yichen Li ^{c, 1} ,
Xiaoxuan Guan ^c ,
Mingjing Yin ^d ,
Wenquan Lv ^d ,
Yin Chen ^a ,
Fei Lu ^d ,
Tao Qin ^d ,
Huyang Gao ^c ,
Weiqian Jin ^c ,
Yifu Huang ^b ,
Cuiping Li ^{e, f, *,} ,
Ming Gao ^{c, *,} ,
Junyu Lu ^{a, *,}

a.
Intensive Care Unit, The Second Affiliated Hospital of Guangxi Medical University, Nanning 530007, China
b.
Department of Critical Care Medicine, The Ninth Affiliated Hospital of Guangxi Medical University, Beihai 536000, China
c.
Life Sciences Institute, Guangxi Medical University, Nanning 530021, China
d.
Department of Emergency, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China
e.
College & Hospital of Stomatology, Guangxi Medical University, Nanning 530021, China
f.
Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Guangxi Medical University, Nanning 530021, China

gxcuiping@sina.com

gaoming1983125@hotmail.com

junyulu@gxmu.edu.cn

Received Date: 12 April 2024
Revised Date: 26 June 2024
Accepted Date: 3 July 2024
Available Online: 4 July 2024

Figures(3)

Acute lung injury (ALI) was characterized by excessive reactive oxygen species (ROS) levels and inflammatory response in the lung. Scavenging ROS could inhibit the excessive inflammatory response, further treating ALI. Herein, we designed a novel nanozyme (P@Co) comprised of polydopamine (PDA) nanoparticles (NPs) loading with ultra-small Co, combining with near infrared (NIR) irradiation, which could efficiently scavenge intracellular ROS and suppress inflammatory responses against ALI. For lipopolysaccharide (LPS) induced macrophages, P@Co + NIR presented excellent antioxidant and anti-inflammatory capacities through lowering intracellular ROS levels, decreasing the expression levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) as well as inducing macrophage M2 directional polarization. Significantly, it displayed the outstanding activities of lowering acute lung inflammation, relieving diffuse alveolar damage, and up-regulating heat shock protein 70 (HSP70) expression, resulting in synergistic enhanced ALI therapy effect. It offers a novel strategy for the clinical treatment of ROS related diseases.
- Acute lung injury,
- NIR driven,
- Nanozyme,
- ROS scavenging,
- M2 directional polarization
1. [1]
  J. Yao, X. Chen, F. Meng, et al., Brain Behav. Immun. 115 (2024) 109–117. doi: 10.1016/j.bbi.2023.10.002
2. [2]
  I. Martin-Loeches, L.F. Reyes, S. Nseir, et al., Intensive Care Med. 49 (2023) 1212–1222. doi: 10.1007/s00134-023-07210-9
3. [3]
  N.J. Meyer, L. Gattinoni, C.S. Calfee, Lancet 398 (2021) 622–637. doi: 10.1016/S0140-6736(21)00439-6
4. [4]
  L.D.J. Bos, L.B. Ware, Lancet 400 (2022) 1145–1156. doi: 10.1016/S0140-6736(22)01485-4
5. [5]
  H. Li, X. Chen, J. Xu, et al., Hepatology 79 (2024) 392–408. doi: 10.1097/hep.0000000000000531
6. [6]
  R. Yuan, Y. Li, S. Han, et al., ACS Cent. Sci. 8 (2022) 10–21. doi: 10.1021/acscentsci.1c00866
7. [7]
  Y. Zhao, Z. Zhang, Z. Pan, et al., Exploration 1 (2021) 20210089. doi: 10.1002/EXP.20210089
8. [8]
  H. Li, P. Yang, J. Hwang, et al., Biomater. Transl. 3 (2022) 162–171.
9. [9]
  M. Chang, Z. Wang, C. Dong, et al., Adv. Mater. 35 (2023) e2208817. doi: 10.1002/adma.202208817
10. [10]
  Y. Li, J. Lin, Y. He, et al., Exploration 3 (2023) 20230054.
11. [11]
  X. Li, L. Chen, M. Huang, et al., Asian J. Pharm. Sci. 18 (2023) 100775. doi: 10.1016/j.ajps.2023.100775
12. [12]
  M. Wang, P. Ma, J. Lin, Chin. Chem. Lett. 34 (2023) 108300. doi: 10.1016/j.cclet.2023.108300
13. [13]
  D. Furtado, M. Björnmalm, S. Ayton, et al., Adv. Mater. 30 (2018) e1801362. doi: 10.1002/adma.201801362
14. [14]
  Z. Geng, Z. Cao, J. Liu, Exploration 3 (2023) 20210117. doi: 10.1002/EXP.20210117
15. [15]
  D. Li, E. Ha, Z. Zhou, et al., Adv. Mater. 1 (2023) e2308747.
16. [16]
  M.L. Alfieri, T. Weil, D.Y.W. Ng, et al., Adv. Colloid. Interface Sci. 305 (2022) 102689. doi: 10.1016/j.cis.2022.102689
17. [17]
  B. Chen, L. Mei, R. Fan, et al., Asian J. Pharm. Sci. 18 (2023) 100781. doi: 10.1016/j.ajps.2023.100781
18. [18]
  N. Chen, W. Fu, J. Zhou, et al., Chin. Chem. Lett. 32 (2021) 2405–2410. doi: 10.1016/j.cclet.2021.02.030
19. [19]
  H. Hu, X. Liu, J. Hong, et al., J. Colloid. Interface Sci. 612 (2022) 246–260. doi: 10.1016/j.jcis.2021.12.172
20. [20]
  Y. Li, L. Yang, Y. Hou, et al., Bioact. Mater. 18 (2022) 213–227.
21. [21]
  S. Shahrokhian, S. Rezaee, Electrochim. Acta 259 (2018) 36–47. doi: 10.1016/j.electacta.2017.10.141
22. [22]
  Y. Chen, H. Zou, B. Yan, et al., Adv. Sci. 9 (2022) e2103977. doi: 10.1002/advs.202103977
23. [23]
  A. Jin, Y. Wang, K. Lin, et al., Bioact. Mater. 5 (2020) 522–541.
24. [24]
  P. Chen, Z. Li, D. Zhang, et al., Chin. Chem. Lett. 34 (2023) 108346.
25. [25]
  P.B. Balakrishnan, N. Silvestri, T. Fernandez-Cabada, et al., Adv. Mater. 32 (2020) e2003712. doi: 10.1002/adma.202003712
26. [26]
  F. Cao, L. Zhang, Y. You, et al., Angew. Chem. Int. Ed. 59 (2020) 5108–5115. doi: 10.1002/anie.201912182
27. [27]
  S. Cai, J. Liu, J. Ding, et al., Angew. Chem. Int. Ed. 61 (2022) 61-48.
28. [28]
  W. Liu, X. Song, W. Liu, et al., Chem. Mater. 34 (2022) 10606–10622. doi: 10.1021/acs.chemmater.2c02686
29. [29]
  Y. Xing, L. Li, Y. Chen, et al., ACS Nano 17 (2023) 6731–6744. doi: 10.1021/acsnano.2c12698
30. [30]
  H. Zhu, S. Huang, M. Ding, et al., ACS Appl. Mater. Interfaces 14 (2022) 25183–25196. doi: 10.1021/acsami.2c05170
31. [31]
  M. Bao, K. Wang, J. Li, et al., Acta Biomater. 161 (2023) 250–264. doi: 10.1016/j.actbio.2023.02.026
32. [32]
  Z. Li, Y. Feng, S. Zhang, et al., ACS Nano 17 (2023) 8551–8563. doi: 10.1021/acsnano.3c00906
33. [33]
  X. Chen, Y. Yang, Q. Mai, et al., Biomaterials 304 (2024) 122384. doi: 10.1016/j.biomaterials.2023.122384
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2. [2]
  Qi Huang , Jun Liao , Jingjing Li , Zhengyan Gu , Xinkang Zhang , Mingxue Sun , Wenqi Meng , Guanchao Mao , Zhipeng Pei , Shanshan Zhang , Songling Li , Chuan Zhang , Yunqin Wang , Jihao Liu , Tingbin Shu , Min Tao , Ying Lu , Kai Xiao , Qingqiang Xu , Jincai Lu . Curcumin-loaded ceria nanoenzymes for dual-action suppression of inflammation and alleviation of oxidative damage in the treatment of acute lung injury. Chinese Chemical Letters, 2025, 36(4): 109914-. doi: 10.1016/j.cclet.2024.109914
3. [3]
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4. [4]
  Jia Chen , Yun Liu , Zerong Long , Yan Li , Hongdeng Qiu . Colorimetric detection of α-glucosidase activity using Ni-CeO₂ nanorods and its application to potential natural inhibitor screening. Chinese Chemical Letters, 2024, 35(9): 109463-. doi: 10.1016/j.cclet.2023.109463
5. [5]
  Caixia Zhu , Qing Hong , Kaiyuan Wang , Yanfei Shen , Songqin Liu , Yuanjian Zhang . Single nanozyme-based colorimetric biosensor for dopamine with enhanced selectivity via reactivity of oxidation intermediates. Chinese Chemical Letters, 2024, 35(10): 109560-. doi: 10.1016/j.cclet.2024.109560
6. [6]
  Manoj Kumar Sarangi , L․D Patel , Goutam Rath , Sitansu Sekhar Nanda , Dong Kee Yi . Metal organic framework modulated nanozymes tailored with their biomedical approaches. Chinese Chemical Letters, 2024, 35(11): 109381-. doi: 10.1016/j.cclet.2023.109381
7. [7]
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8. [8]
  Shaobin He , Xiaoyun Guo , Qionghua Zheng , Huanran Shen , Yuan Xu , Fenglin Lin , Jincheng Chen , Haohua Deng , Yiming Zeng , Wei Chen . Engineering nickel-supported osmium bimetallic nanozymes with specifically improved peroxidase-like activity for immunoassay. Chinese Chemical Letters, 2025, 36(4): 110096-. doi: 10.1016/j.cclet.2024.110096
9. [9]
  Ji Liu , Dongsheng He , Tianjiao Hao , Yumin Hu , Yan Zhao , Zhen Li , Chang Liu , Daquan Chen , Qiyue Wang , Xiaofei Xin , Yan Shen . Gold mineralized "hybrid nanozyme bomb" for NIR-II triggered tumor effective permeation and cocktail therapy. Chinese Chemical Letters, 2024, 35(9): 109296-. doi: 10.1016/j.cclet.2023.109296
10. [10]
  Shangqian Zhang , Jiaxuan Li , Xuan Hu , Zelong Chen , Junliang Dong , Chenhao Hu , Shuang Chao , Yinghua Lv , Yuxin Pei , Zhichao Pei . H₂S and NIR light-driven nanomotors induce disulfidptosis for targeted anticancer therapy by enhancing disruption of tumor metabolic symbiosis. Chinese Chemical Letters, 2025, 36(1): 110314-. doi: 10.1016/j.cclet.2024.110314
11. [11]
  Yu Dai , Xueting Sun , Haoyu Wu , Naizhu Li , Guoe Cheng , Xiaojin Zhang , Fan Xia . Determination of the Michaelis Constant for Gold Nanozyme-Catalyzed Decomposition of Hydrogen Peroxide. University Chemistry, 2025, 40(5): 351-356. doi: 10.12461/PKU.DXHX202407052
12. [12]
  Simin Wei , Yaqing Yang , Junjie Li , Jialin Wang , Jinlu Tang , Ningning Wang , Zhaohui Li . The Mn/Yb/Er triple-doped CeO₂ nanozyme with enhanced oxidase-like activity for highly sensitive ratiometric detection of nitrite. Chinese Chemical Letters, 2024, 35(6): 109114-. doi: 10.1016/j.cclet.2023.109114
13. [13]
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14. [14]
  Zhenyu Hu , Zhenchun Yang , Shiqi Zeng , Kun Wang , Lina Li , Chun Hu , Yubao Zhao . Cationic surface polarization centers on ionic carbon nitride for efficient solar-driven H₂O₂ production and pollutant abatement. Chinese Chemical Letters, 2024, 35(10): 109526-. doi: 10.1016/j.cclet.2024.109526
15. [15]
  Mengmeng Yuan , Xiwen Hu , Na Li , Limin Xu , Mengxi Zhu , Xing Pei , Rui Li , Lu Sun , Yupeng Chen , Fei Yu , Huining He . Kidney targeted delivery of siRNA mediated by peptide-siRNA conjugate for the treatment of acute kidney injury. Chinese Chemical Letters, 2025, 36(6): 110251-. doi: 10.1016/j.cclet.2024.110251
16. [16]
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17. [17]
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18. [18]
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19. [19]
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20. [20]
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