Citation: Zhi Li, Shuya Pan, Yuan Tian, Shaowei Liu, Weifeng Wei, Jinlin Wang, Tianfeng Chen, Ling Wang. Selenium nanoparticles enhance the chemotherapeutic efficacy of pemetrexed against non-small cell lung cancer[J]. Chinese Chemical Letters, ;2024, 35(12): 110018. doi: 10.1016/j.cclet.2024.110018 shu

Selenium nanoparticles enhance the chemotherapeutic efficacy of pemetrexed against non-small cell lung cancer

Zhi Li ^a ,
Shuya Pan ^b ,
Yuan Tian ^c ,
Shaowei Liu ^d ,
Weifeng Wei ^d ,
Jinlin Wang ^d ,
Tianfeng Chen ^{a, c, *,} ,
Ling Wang ^{a, *,}

a.
Faculty of Medicine, Macau University of Science and Technology, Macao 999078, China
b.
Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, China
c.
College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, China
d.
Pulmonary and Critical Care Medicine, Guangzhou Institute of Respiratory Health, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, State Key Laboratory of Respiratory Diseases, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China

tchentf@jnu.edu.cn

lingwang@must.edu.mo

Received Date: 11 April 2024
Revised Date: 12 May 2024
Accepted Date: 15 May 2024
Available Online: 16 May 2024

Figures(5)

Selenium (Se) plays an important role in the development and treatment of lung cancer, yet its specific mechanisms remain elusive. Lower Se level in serum was noted in lung cancer patients compared to normal controls. Therefore, developing effective therapeutic adjuvants containing Se might benefit the treatment of lung cancer patients. This study aimed to investigate the association between Se and the chemotherapeutic efficacy of lung cancer. Lentinan-modified selenium nanoparticles (LET-SeNPs) were created to develop and verify the effectiveness of Se containing adjuvant applied with pemetrexed on lung cancer cells. A synergistic effect was observed between LET-SeNPs and pemetrexed in vitro. The combination of LET-SeNPs and pemetrexed could induce reactive oxygen species overproduction, mitochondrial dysfunction and DNA damage, ultimately leading to cancer cell apoptosis. It is implied that LET-SeNPs might be a promising sensitizer to pemetrexed chemotherapy and could potentially enhance chemotherapy efficiency in non-small cell lung cancer.
- Selenium nanoparticles,
- Lentinan,
- Chemotherapy,
- Pemetrexed,
- Non-small cell lung cancer,
- Apoptosis
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沈阳化工大学材料科学与工程学院沈阳 110142