Citation: Zheng-Biao Zou, Tai-Zong Wu, Chun-Lan Xie, Yuan Wang, Yan Li, Gang Zhang, Rong Chao, Lian-Zhong Luo, Li-Sheng Li, Xian-Wen Yang. neo-Dicitrinols A–C: Unprecedented PKS-NRPS hybrid citrinin dimers with ferroptosis inhibitory activity from the deep-sea-derived Penicillium citrinum W22[J]. Chinese Chemical Letters, ;2024, 35(12): 109723. doi: 10.1016/j.cclet.2024.109723 shu

neo-Dicitrinols A–C: Unprecedented PKS-NRPS hybrid citrinin dimers with ferroptosis inhibitory activity from the deep-sea-derived Penicillium citrinum W22

Zheng-Biao Zou ^{a, b, 1} ,
Tai-Zong Wu ^{b, 1} ,
Chun-Lan Xie ^{a, b} ,
Yuan Wang ^b ,
Yan Li ^c ,
Gang Zhang ^d ,
Rong Chao ^b ,
Lian-Zhong Luo ^d ,
Li-Sheng Li ^c ,
Xian-Wen Yang ^{a, b, *,}

a.
School of Pharmacy, Hainan Medical University, Haikou 571199, China
b.
Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen 361005, China
c.
The School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350122, China
d.
Fujian Province Universities and Colleges Engineering Research Center for Marine Biopharmaceutical Resource Utilization, Xiamen Medica College, Xiamen 361023, China

yangxianwen@tio.org.cn

Received Date: 3 February 2024
Revised Date: 26 February 2024
Accepted Date: 27 February 2024
Available Online: 11 March 2024

Figures(8)

The chemical investigation into the EtOAc extract of the deep-sea-derived fungus Penicillium citrinum W22 yielded three unprecedented citrinin dimers, neo-Dicitrinols A–C (1–3) and a known one, penicitrinone A (4). Their structures were elucidated by extensive analysis of spectroscopic data, electronic circular dichroism (ECD) calculation, X-ray diffraction, and biogenetic consideration. neo-Dicitrinols A–C (1–3), bearing a tetramic acid unit, represent the first example of citrinin analogues as hybrid polyketide synthase-nonribosomal peptide synthase (PKS-NRPS) products. neo-Dicitrinol C (3) significantly inhibited renin-angiotensin system-selective lethal 3 (RSL3)-induced ferroptosis with a half maximal effective concentration (EC₅₀) value of 21.6 µmol/L.
- Deep-sea,
- Fungus,
- Citrinin dimers,
- PKS-NRPS hybrid,
- Ferroptosis
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