Citation: Biao Huang, Tao Tang, Fushou Liu, Shi-Hui Chen, Zhi-Ling Zhang, Mingxi Zhang, Ran Cui. Quantum dots boost large-view NIR-Ⅱ imaging with high fidelity for fluorescence-guided tumor surgery[J]. Chinese Chemical Letters, ;2024, 35(12): 109694. doi: 10.1016/j.cclet.2024.109694 shu

Quantum dots boost large-view NIR-Ⅱ imaging with high fidelity for fluorescence-guided tumor surgery

Biao Huang ^{a, 1} ,
Tao Tang ^{a, 1} ,
Fushou Liu ^a ,
Shi-Hui Chen ^a ,
Zhi-Ling Zhang ^a ,
Mingxi Zhang ^b ,
Ran Cui ^{a, *,}

a.
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China
b.
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China

cuiran@whu.edu.cn

Received Date: 20 November 2023
Revised Date: 15 February 2024
Accepted Date: 27 February 2024
Available Online: 6 March 2024

Figures(5)

Owing to the high spatiotemporal resolution, the second near-infrared (NIR-Ⅱ) imaging window can provide high imaging contrast with diminished tissue autofluorescence and suppressed photon scattering to pinpoint the locations for tumor surgery. Due to the unique optical properties and excellent fluorescence performance, quantum dots (QDs) are regarded as ideal nanoprobes for fluorescence-guided surgery (FGS). Moreover, QDs can be excited by a variety of light sources owing to the continuous and wide absorption ranges. Herein, light-emitting diode (LED) was used as the excitation source of QDs-based nanoprobes to realize FGS of tumor with high resolution. Since the LED light could irradiate a large region with consistent light intensity, signal distortion at the edge of imaging field was avoided. The signal intensity of the view edges under LED excitation can be improved by about 5 times compared to laser excitation. Therefore, more micro-vessels and smaller tumors (V_tumor < 5 mm²) could be detected, thus providing more precise guidance for tumor resection surgery.
- NIR-Ⅱ imaging,
- Fluorescence-guided surgery,
- Quantum dots,
- Light-emitting diode,
- Tumor imaging
1. [1]
  Z. Hu, C. Fang, B. Li, et al., Nat. Biomed. Eng. 4 (2020) 259–271.
2. [2]
  J.S.D. Mieog, F.B. Achterberg, A. Zlitni, et al., Nat. Rev. Clin. Oncol. 19 (2022) 9–22. doi: 10.1038/s41571-021-00548-3
3. [3]
  F. Wang, L. Qu, F. Ren, et al., Proc. Natl. Acad. Sci. U. S. A. 119 (2022) e2123111119. doi: 10.1073/pnas.2123111119
4. [4]
  S. Hernot, L. Manen, P. Debie, et al., Lancet Oncol. 20 (2019) 354–367. doi: 10.1016/S1470-2045(19)30317-1
5. [5]
  Y.Y. Duo, L. Zhao, Z.G. Wang, et al., J. Anal. Test. 7 (2023) 245–259. doi: 10.1007/s41664-023-00254-2
6. [6]
  Y. Yang, D. Liu, Z. He, et al., Adv. Healthcare Mater. 12 (2023) 2300434. doi: 10.1002/adhm.202300434
7. [7]
  C. Li, Y. Pang, Y. Xu, et al., Chem. Soc. Rev. 52 (2023) 4392–4442. doi: 10.1039/d3cs00227f
8. [8]
  S. He, J. Song, J. Qu, et al., Chem. Soc. Rev. 47 (2018) 4258–4278. doi: 10.1039/c8cs00234g
9. [9]
  X. Song, R. Wang, J. Gao, et al., Chin. Chem. Lett. 33 (2022) 1567–1571. doi: 10.1016/j.cclet.2021.08.111
10. [10]
  Y. Chen, P. Pei, Z. Lei, et al., Angew. Chem. Int. Ed. 60 (2021) 15809–15815. doi: 10.1002/anie.202103071
11. [11]
  H. Zhang, C. Sun, L. Sun, et al., Angew. Chem. Int. Ed. 61 (2022) e202203851. doi: 10.1002/anie.202203851
12. [12]
  J. Zheng, S.H. Chen, B. Huang, et al., Chin. Chem. Lett. 35 (2024) 108460. doi: 10.1016/j.cclet.2023.108460
13. [13]
  R. Tian, H. Ma, S. Zhu, et al., Adv. Mater. 32 (2020) 1907365. doi: 10.1002/adma.201907365
14. [14]
  P. Wang, J. Li, M. Wei, et al., Biomaterials 287 (2022) 121636. doi: 10.1016/j.biomaterials.2022.121636
15. [15]
  H.L. Xu, J.J. Yang, D.L. Zhuge, et al., Adv. Healthcare Mater. 7 (2018) 1701130. doi: 10.1002/adhm.201701130
16. [16]
  S. Qu, Q. Jia, Z. Li, et al., Sci. Bull. 67 (2022) 1274–1283. doi: 10.1016/j.scib.2022.05.001
17. [17]
  C. Sun, X. Sun, P. Pei, et al., Adv. Funct. Mater. 31 (2021) 2100656. doi: 10.1002/adfm.202100656
18. [18]
  H. Zhou, S. Li, X. Zeng, et al., Chin. Chem. Lett. 31 (2020) 1382–1386. doi: 10.1016/j.cclet.2020.04.030
19. [19]
  X. Zhou, Q. Liu, W. Yuan, et al., Adv. Sci. 8 (2021) 2000441. doi: 10.1002/advs.202000441
20. [20]
  P. Wang, Y. Fan, L. Lu, et al., Nat. Commun. 9 (2018) 2898. doi: 10.1038/s41467-018-05113-8
21. [21]
  D. Li, S. He, Y. Wu, et al., Adv. Sci. 6 (2019) 1902042. doi: 10.1002/advs.201902042
22. [22]
  J. Jin, L. Yang, F. Chen, et al., Interdiscip. Mater. 1 (2022) 471–494. doi: 10.1002/idm2.12050
23. [23]
  D. Liu, Z. He, Y. Zhao, et al., J. Am. Chem. Soc. 143 (2021) 17136–17143. doi: 10.1021/jacs.1c07711
24. [24]
  Q. Wen, Y. Zhang, C. Li, et al., Angew. Chem. Int. Ed. 58 (2019) 11001–11006. doi: 10.1002/anie.201905643
25. [25]
  G.T. Yu, M.Y. Luo, H. Li, et al., ACS Nano 13 (2019) 12830–12839. doi: 10.1021/acsnano.9b05038
26. [26]
  Z. Feng, T. Tang, T. Wu, et al., Light: Sci. Appl. 10 (2021) 197. doi: 10.1038/s41377-021-00628-0
27. [27]
  W. Zhang, T. Chen, L. Su, et al., Anal. Chem. 92 (2020) 6094–6102. doi: 10.1021/acs.analchem.0c00529
28. [28]
  H. Yang, R. Li, Y. Zhang, et al., J. Am. Chem. Soc. 143 (2021) 2601–2607. doi: 10.1021/jacs.0c13071
29. [29]
  Z.Y. Liu, A.A. Liu, H. Fu, et al., J. Am. Chem. Soc. 143 (2021) 12867–12877. doi: 10.1021/jacs.1c06661
30. [30]
  J. Zhang, A. Bifulco, P. Amato, et al., J. Colloid Interf. Sci. 638 (2023) 193–219. doi: 10.1016/j.jcis.2023.01.107
31. [31]
  C. Mahajan, A. Sharma, A.K. Rath, ACS Appl. Mater. Interfaces 12 (2020) 49840–49848. doi: 10.1021/acsami.0c15703
32. [32]
  L. Lu, B. Li, S. Ding, et al., Nat. Commun. 11 (2020) 4192. doi: 10.1038/s41467-020-18051-1
33. [33]
  J. Liu, H. Rijckaert, M. Zeng, et al., Adv. Funct. Mater. 28 (2018) 1707365. doi: 10.1002/adfm.201707365
34. [34]
  Q. Liu, J. Tian, Y. Tian, et al., Acta Biomater 127 (2021) 287–297. doi: 10.1016/j.actbio.2021.03.064
35. [35]
  S. Fan, S. Wang, C. Yang, et al., Adv. Optical Mater. 23 (2023) 2202945. doi: 10.1002/adom.202202945
36. [36]
  N. Liu, X. Chen, X. Sun, et al., J. Nanobiotechnol 19 (2021) 113. doi: 10.1186/s12951-021-00862-z
37. [37]
  A. Satpathy, W.T. Huang, M.H. Chan, et al., Adv. Optical Mater. 11 (2023) 2300321. doi: 10.1002/adom.202300321
38. [38]
  Z. Feng, Y. Li, S. Chen, et al., Nat. Commun. 14 (2023) 5017. doi: 10.1038/s41467-023-40728-6
39. [39]
  B. Li, M. Zhao, J. Lin, et al., Chem. Soc. Rev. 51 (2022) 7692–7714. doi: 10.1039/d2cs00131d
40. [40]
  Y. Liu, Z. Zhou, F. Wang, et al., Nat. Commun. 12 (2021) 2019. doi: 10.1038/s41467-021-22283-0
41. [41]
  C. Chen, B. Liu, Y. Liu, et al., Adv. Mater. 33 (2021) 2008847. doi: 10.1002/adma.202008847
42. [42]
  S. Jia, J.C. Vaughan, X. Zhuang, Nat. Photonics 8 (2014) 302–306. doi: 10.1038/nphoton.2014.13
43. [43]
  M. Wei, J. Bai, X. Shen, et al., ACS Nano 17 (2023) 11345–11361. doi: 10.1021/acsnano.3c00350
44. [44]
  T. Pu, Y. Liu, Y. Pei, et al., ACS Appl. Mater. Interfaces 15 (2023) 32226–32239. doi: 10.1021/acsami.3c04949
45. [45]
  Y. Wang, J. Nan, H. Ma, et al., Nano Lett. 23 (2023) 4039–4048. doi: 10.1021/acs.nanolett.3c00829
46. [46]
  M. Wenes, M. Shang, M. Di Matteo, et al., Cell Metab. 24 (2016) 701–715. doi: 10.1016/j.cmet.2016.09.008
47. [47]
  T. Tang, B. Huang, F. Liu, et al., Nanoscale 14 (2022) 7473–7479. doi: 10.1039/d2nr01175a
48. [48]
  N. Pashayan, P.D.P. Pharoah, Science 368 (2022) 589–590.
49. [49]
  J. Huang, X. Chen, Y. Jiang, et al., Nat. Mater. 21 (2022) 598–607. doi: 10.1038/s41563-022-01224-2
50. [50]
  Y. Zhou, B. Huang, S.H. Chen, et al., Nano Res. 16 (2023) 2719–2727. doi: 10.1007/s12274-022-4875-6
51. [51]
  A.M. Saeboe, A.Y. Nikiforov, R. Toufanian, et al., Nano Lett. 21 (2021) 3271–3279. doi: 10.1021/acs.nanolett.1c00600
52. [52]
  Q. Ding, J. Zhao, H. Zhang, et al., Angew. Chem. Int. Ed. 61 (2022) e202210370. doi: 10.1002/anie.202210370
53. [53]
  J.X. Sun, J.Z. Xu, Y. An, et al., J. Control. Release 353 (2023) 832–841. doi: 10.1016/j.jconrel.2022.12.013
54. [54]
  B. Huang, J. Hu, H. Li, et al., ACS Appl. Bio Mater. 3 (2020) 1636–1645. doi: 10.1021/acsabm.9b01202
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