Citation: Jiahao Liu, Peng Liu, Junhong Duan, Qiongxuan Xie, Jie Feng, Hongpei Tan, Ze Mi, Ying Li, Yunjie Liao, Pengfei Rong, Wenhu Zhou, Xiang Gao. Macrophages-mediated tumor accumulation and deep penetration of bismuth/manganese biomineralized nanoparticles for enhanced radiotherapy[J]. Chinese Chemical Letters, ;2024, 35(12): 109632. doi: 10.1016/j.cclet.2024.109632 shu

Macrophages-mediated tumor accumulation and deep penetration of bismuth/manganese biomineralized nanoparticles for enhanced radiotherapy

Jiahao Liu ^{a, b, 1} ,
Peng Liu ^{c, d, 1} ,
Junhong Duan ^b ,
Qiongxuan Xie ^e ,
Jie Feng ^a ,
Hongpei Tan ^b ,
Ze Mi ^b ,
Ying Li ^f ,
Yunjie Liao ^b ,
Pengfei Rong ^{b, *,} ,
Wenhu Zhou ^{a, *,} ,
Xiang Gao ^{g, *,}

a.
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China
b.
Department of Radiology, The Third Xiangya Hospital, Central South University, Changsha 410013, China
c.
Department of Nuclear Medicine, XiangYa Hospital, Central South University, Changsha 410008, China
d.
Key Laboratory of Biological Nanotechnology, NHC, Changsha 410013, China
e.
Department of Oncology, Xiangya Hospital, Central South University, Changsha 410008, China
f.
Department of Nursing, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha 410005, China
g.
State Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, Beijing 100050, China

rongpengfei66@163.com

zhouwenhuyaoji@163.com

gaoxiang609@163.com

Received Date: 10 November 2023
Revised Date: 6 February 2024
Accepted Date: 7 February 2024
Available Online: 10 February 2024

Figures(6)

Radiotherapy (RT) is a widely used cancer treatment, and the use of metal-based nano-radiotherapy sensitizers has shown promise in enhancing its efficacy. However, efficient accumulation and deep penetration of these sensitizers within tumors remain challenging. In this study, we present the development of bismuth/manganese biomineralized nanoparticles (BiMn/BSA) with multiple radiosensitizing mechanisms, including high atomic number element-mediated radiation capture, catalase-mimic oxygenation, and activation of the stimulator of interferon genes (STING) pathway. Significantly, we demonstrate that low-dose RT induces the recruitment of macrophages and subsequent upregulation of Matrix metalloproteinases (MMP)-2 and MMP-9 that degrade the extracellular matrix (ECM). This dynamic process facilitates the targeted delivery and deep penetration of BiMn/BSA nanoparticles within tumors, thereby enhancing the effectiveness of RT. By combining low-dose RT with BiMn/BSA nanoparticles, we achieved complete suppression of tumor growth in mice with excellent biocompatibility. This study provides a novel and clinically relevant strategy for targeted nanoparticle delivery to tumors, and establishes a safe and effective sequential radiotherapy approach for cancer treatment. These findings hold great promise for improving the outcomes of RT and advancing the field of nanomedicine in cancer therapy.
- Radiotherapy sensitizers,
- Metal-based nanoparticles,
- Targeted nanoparticle delivery,
- STING pathway activation,
- Sequential radiotherapy
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沈阳化工大学材料科学与工程学院沈阳 110142