Citation: Wenkai Liu, Yanxian Hou, Weijian Liu, Ran Wang, Shan He, Xiang Xia, Chengyuan Lv, Hua Gu, Qichao Yao, Qingze Pan, Zehou Su, Danhong Zhou, Wen Sun, Jiangli Fan, Xiaojun Peng. Se-substituted pentamethine cyanine for anticancer photodynamic therapy mediated using the hot band absorption process[J]. Chinese Chemical Letters, ;2024, 35(12): 109631. doi: 10.1016/j.cclet.2024.109631 shu

Se-substituted pentamethine cyanine for anticancer photodynamic therapy mediated using the hot band absorption process

Wenkai Liu ^a ,
Yanxian Hou ^a ,
Weijian Liu ^b ,
Ran Wang ^a ,
Shan He ^c ,
Xiang Xia ^a ,
Chengyuan Lv ^a ,
Hua Gu ^a ,
Qichao Yao ^a ,
Qingze Pan ^a ,
Zehou Su ^a ,
Danhong Zhou ^a ,
Wen Sun ^{a, *,} ,
Jiangli Fan ^{a, *,} ,
Xiaojun Peng ^a

a.
State Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Dalian University of Technology, Dalian 116024, China
b.
Shandong Laboratory of Yantai Advanced Materials and Green Manufacturing, Yantai 264006, China
c.
Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction and Institute for Advanced Study, The Hong Kong University of Science and Technology, Hong Kong 999077, China

sunwen@dlut.edu.cn

fanjl@dlut.edu.cn

Received Date: 18 December 2023
Revised Date: 2 February 2024
Accepted Date: 3 February 2024
Available Online: 13 February 2024

Figures(4)

Photodynamic therapy (PDT) is a promising cancer treatment modality owing to its high spatiotemporal selectivity and noninvasive nature. However, conventional photosensitizers (PSs) used in PDT are responsive only to visible light, which makes them unsuitable for tissue penetration. In this study, we propose a PS based on hot band absorption (HBA), which can be triggered by anti-Stokes light at 808 nm via a one-photon process. The introduction of selenium (Se) into pentamethine cyanine (Secy5) not only facilitates intersystem crossing for reactive oxygen species (ROS) production but also enhances HBA efficiency, thereby prolonging the excitation wavelength. In addition, Secy5 demonstrates excellent biocompatibility, unlike its I-substituted counterpart (Icy5), and produces not only ¹O₂ but also O₂^•−, making it a desirable candidate for treating hypoxic solid tumors. According to the results of in vivo and in vitro experiments, Secy5 can efficiently inhibit cancer cell growth via anti-Stokes activation processes, thereby providing a novel approach to design anti-Stokes excitation PSs for anticancer treatment.
- Cyanine dyes,
- Hot band absorption,
- Anti-Stokes,
- Photodynamic therapy,
- Anticancer treatment
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