Citation: Shuige Zhao, Pengcheng Yan, Peipei Liu, Haishan Liu, Ning Li, Peng Fu, Weiming Zhu. Pyridapeptides F‒I, cyclohexapeptides from marine sponge-derived Streptomyces sp. OUCMDZ-4539[J]. Chinese Chemical Letters, ;2024, 35(7): 108950. doi: 10.1016/j.cclet.2023.108950 shu

Pyridapeptides F‒I, cyclohexapeptides from marine sponge-derived Streptomyces sp. OUCMDZ-4539

Shuige Zhao ^{a, 1} ,
Pengcheng Yan ^{a, 1} ,
Peipei Liu ^a ,
Haishan Liu ^c ,
Ning Li ^d ,
Peng Fu ^{a, b, *,} ,
Weiming Zhu ^{a, b, *,}

a.
Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
b.
Key Laboratory for Marine Drugs and Bioproducts, Laoshan Laboratory, Qingdao 266237, China
c.
School of Biological Science and Technology, University of Jinan, Ji'nan 250022, China
d.
Key Laboratory for Biosensors of Shandong Province, Biology Institute, Qilu University of Technology, Ji'nan 250103, China

fupeng@ouc.edu.cn

weimingzhu@hotmail.com

Received Date: 27 June 2023
Revised Date: 17 August 2023
Accepted Date: 18 August 2023
Available Online: 19 August 2023

Figures(3)

Four new cyclohexapeptides, pyridapeptides F–I (1–4), were isolated from the fermentation broth of marine sponge-derived Streptomyces sp. OUCMDZ-4539. The pyridapeptides F–H (1–3) are composed of β-hydroxyleucine, alanine, O-methylthreonine, hexahydropyridazine-3-carboxylic acid, 5-hydroxytetrahydropyridazine-3-carboxylic acid, and (2S,3R,4E,6E)-2-amino-3–hydroxy-4,6-dienoic acid residues. Pyridapeptide Ⅰ (4) contains (2S,3R,4E,6E)-2-amino-3–hydroxy-8-methylnona-4,6-dienoic acid residue and a very rare glycose residue, aculose. Their structures were determined based on spectroscopic analysis and chemical methods. Pyridapeptides G–I (2–4) have the 2,3,6-trideoxyhexose units glycosylated at the γ-OH-TPDA residue, displayed significant antiproliferative activity against four (PC9, MKN45, HepG2, K562) or two (PC9, MKN45) human cancer cell lines.
- Marine microorganism,
- Streptomyces,
- Cyclopeptide glycosides,
- Pyridapeptides,
- Antiproliferative activity
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沈阳化工大学材料科学与工程学院沈阳 110142