Citation: Hongxia Li, Xiyang Wang, Du Qiao, Jiahao Li, Weiping Zhu, Honglin Li. Mechanism of nanoparticle aggregation in gas-liquid microfluidic mixing[J]. Chinese Chemical Letters, ;2024, 35(4): 108747. doi: 10.1016/j.cclet.2023.108747 shu

Mechanism of nanoparticle aggregation in gas-liquid microfluidic mixing

Hongxia Li ^{a, *,} ,
Xiyang Wang ^a ,
Du Qiao ^a ,
Jiahao Li ^a ,
Weiping Zhu ^b ,
Honglin Li ^b

a.
Key Laboratory for Precision & Non-traditional Machining Technology of Ministry of Education, Dalian University of Technology, Dalian 116023, China
b.
Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China

hxli@dlut.edu.cn

Received Date: 19 April 2023
Revised Date: 16 June 2023
Accepted Date: 27 June 2023
Available Online: 2 July 2023

Figures(6)

Using gas-liquid segmented micromixers to prepare nanoparticles that have a homogeneous particle size, controllable shape, and monodispersity advantages. Although nanoparticle aggregation within a microfluid has been shown to be affected by the shear effect, the shear effect triggering conditions in gas-liquid two-phase flow is unclear and the aggregation behavior of nanoparticles under the shear effect is difficult to predict, resulting in uncontrollable physical and chemical properties of nanoparticle aggregates. In this study, a numerical simulation of nanoparticle aggregation in gas-liquid two-phase flow under the shear effect is performed using the CFD-DEM method. Then, the effects of total flow rate, gas-liquid two-phase flow ratio, and particle volume fraction on particle aggregation were analyzed to achieve control of particle aggregation shape and size. Meanwhile, the triggering mechanism of the shear effect and the mechanism of the shear effect on the aggregation of nanoparticles were clarified. The results show that increasing the total flow rate or decreasing the gas-liquid two-phase flow rate ratio can induce the shear effect, which reduces the particle aggregation size and makes the morphology tend to be spherical. Moreover, increasing the particle volume fraction, and total flow rate or decreasing the gas-liquid two-phase flow rate ratio also increases the number of particle collisions and induce interparticle adhesion. Hence, particle adhesion and the shear effect compete with each other and together affect particle aggregation.
- Microfluidic,
- Gas-liquid segmented micromixer,
- Nanoparticle aggregation,
- Shear effect,
- Numerical calculation
1. [1]
  S. Swain, P.K. Sahu, S. Beg, S.M. Babu, Curr. Drug Deliv. 13 (2016) 1290–1302. doi: 10.2174/1567201813666160713121122
2. [2]
  U.U.M. Nordin, N. Ahmad, N. Salim, N.S.M. Yusof, RSC Adv. 11 (2021) 29080–29101. doi: 10.1039/D1RA06087B
3. [3]
  J.Q. Wang, W.W. Mao, L.L. Lock, et al., ACS Nano 9 (2015) 7195–7206. doi: 10.1021/acsnano.5b02017
4. [4]
  C. Kinnear, T.L. Moore, L. Rodriguez-Lorenzo, et al., Chem. Rev. 117 (2017) 11476–11521. doi: 10.1021/acs.chemrev.7b00194
5. [5]
  L. Zhang, Q. Feng, J.L. Wang, et al., ACS Nano 9 (2015) 9912–9921. doi: 10.1021/acsnano.5b05792
6. [6]
  L. Zhang, Q. Chen, Y. Ma, J. Sun, ACS Appl. Bio Mater. 3 (2020) 107–120. doi: 10.1021/acsabm.9b00853
7. [7]
  P. Stolzenburg, T. Lorenz, A. Dietzel, G. Garnweitner, Chem. Eng. Sci. 191 (2018) 500–510. doi: 10.1016/j.ces.2018.07.007
8. [8]
  G. Ochoa-Vazquez, B. Kharisov, A. Arizmendi-Morquecho, et al., IEEE Trans. Nanobiosci. 21 (2022) 135–140. doi: 10.1109/TNB.2021.3101189
9. [9]
  D.V. Ravi Kumar, B.L.V. Prasad, A.A. Kulkarni, Chem. Eng. J. 192 (2012) 357–368. doi: 10.1016/j.cej.2012.02.084
10. [10]
  H. Huang, H. du Toit, S. Ben-Jaber, et al., React. Chem. Eng. 4 (2019) 884–890. doi: 10.1039/C8RE00351C
11. [11]
  C.H. Kwak, J.P. Park, S.S. Lee, et al., J. Nanosci. Nanotechnol. 18 (2018) 1339–1342. doi: 10.1166/jnn.2018.14918
12. [12]
  C.W. Wang, A. Oskooei, D. Sinton, M.G. Moffitt, Langmuir 26 (2010) 716–723. doi: 10.1021/la902427r
13. [13]
  G. Schabas, C.W. Wang, A. Oskooei, et al., Langmuir 24 (2008) 10596–10603. doi: 10.1021/la8022985
14. [14]
  Z. Xu, C. Lu, J. Riordon, et al., Langmuir 32 (2016) 12781–12789. doi: 10.1021/acs.langmuir.6b03243
15. [15]
  V. Becker, H. Briesen, Phys. Rev. E 78 (2008) 61404–61413. doi: 10.1103/PhysRevE.78.061404
16. [16]
  V. Becker, H. Briesen, J. Colloid Interface Sci. 346 (2010) 32–36. doi: 10.1016/j.jcis.2010.02.015
17. [17]
  V. Becker, E. Schlauch, M. Behr, H. Briesen, J. Colloid Interface Sci. 339 (2009) 362–372. doi: 10.1016/j.jcis.2009.07.022
18. [18]
  E. De Angelis, M. Chinappi, G. Graziani, Meccanica 47 (2012) 2069–2077. doi: 10.1007/s11012-012-9576-8
19. [19]
  A. Nikoubashman, Soft Matter 13 (2016) 222–229.
20. [20]
  C. Prohm, M. Gierlak, H. Stark, Eur. Phys. J. E 35 (2012) 80. doi: 10.1140/epje/i2012-12080-3
21. [21]
  J.F. Wilson, M. Kroupa, J. Kosek, M. Soos, Langmuir 34 (2018) 15600–15611. doi: 10.1021/acs.langmuir.8b03350
22. [22]
  M. Zeidan, B.H. Xu, X. Jia, R.A. Williams, Chem. Eng. Res. Des. 85 (2007) 1645–1654. doi: 10.1016/S0263-8762(07)73208-2
23. [23]
  C.W. Wang, A. Bains, D. Sinton, M.G. Moffitt, Langmuir 28 (2012) 15756–15761. doi: 10.1021/la303655s
24. [24]
  C.W. Wang, A. Bains, D. Sinton, M.G. Moffitt, Langmuir 29 (2013) 8385–8394. doi: 10.1021/la400011n
25. [25]
  C.W. Wang, D. Sinton, M.G. Moffitt, J. Am. Chem. Soc. 133 (2011) 18853–18864. doi: 10.1021/ja2067252
26. [26]
  D. Qian, A. Lawal, Chem. Eng. Sci. 61 (2006) 7609–7625. doi: 10.1016/j.ces.2006.08.073
27. [27]
  P. Aussillous, D. Quere, Phys. Fluids 12 (2000) 2367–2371. doi: 10.1063/1.1289396
28. [28]
  W. Dijkhuizen, M.V. Annaland, J.A.M. Kuipers, Chem. Eng. Sci. 65 (2010) 1274–1287. doi: 10.1016/j.ces.2009.09.084
29. [29]
  S.B. Yeom, E.S. Ha, M.S. Kim, et al., Pharmaceutics 11 (2019) 414–465. doi: 10.3390/pharmaceutics11080414
30. [30]
  K.L. Johnson, K. Kendall, A.D. Roberts, Proc. R. Soc. Lond. A: Math. Phys. Sci. 324 (1971) 301–313.
31. [31]
  O. Baran, A. DeGennaro, E. Rame, A. Wilkinson, AIP Conference Proceedings 1145 (2009) 409–412.
32. [32]
  Z. Peng, L. Ge, R. Moreno-Atanasio, et al., Chem. Eng. J. 396 (2020) 124738. doi: 10.1016/j.cej.2020.124738
33. [33]
  A.A. Kulkarni, V. Sebastian Cabeza, Langmuir 33 (2017) 14315–14324. doi: 10.1021/acs.langmuir.7b03277
34. [34]
  J. Subero, Z. Ning, M. Ghadiri, C. Thornton, Powder Technol. 105 (1999) 66–73. doi: 10.1016/S0032-5910(99)00119-9
1. [1]
  Wei-Tao Dou , Qing-Wen Zeng , Yan Kang , Haidong Jia , Yulian Niu , Jinglong Wang , Lin Xu . Construction and application of multicomponent fluorescent droplets. Chinese Chemical Letters, 2025, 36(1): 109995-. doi: 10.1016/j.cclet.2024.109995
2. [2]
  Haoyang Wang , Ronghao Zhang , Yanlun Ren , Li Zhang . A convenient method for measuring gas-liquid volumetric mass transfer coefficient in micro reactors. Chinese Chemical Letters, 2024, 35(4): 108833-. doi: 10.1016/j.cclet.2023.108833
3. [3]
  Jun Lu , Jinrui Yan , Yaohao Guo , Junjie Qiu , Shuangliang Zhao , Bo Bao . Controlling solid form and crystal habit of triphenylmethanol by antisolvent crystallization in a microfluidic device. Chinese Chemical Letters, 2024, 35(4): 108876-. doi: 10.1016/j.cclet.2023.108876
4. [4]
  Gaowa Xing , Yuting Shang , Xiaorui Wang , Zengnan Wu , Qiang Zhang , Jiebing Ai , Qiaosheng Pu , Ling Lin . A microfluidic biosensor for multiplex immunoassay of foodborne pathogens agitated by programmed audio signals. Chinese Chemical Letters, 2024, 35(10): 109491-. doi: 10.1016/j.cclet.2024.109491
5. [5]
  Cheng Wang , Ji Wang , Dong Liu , Zhi-Ling Zhang . Advances in virus-host interaction research based on microfluidic platforms. Chinese Chemical Letters, 2024, 35(12): 110302-. doi: 10.1016/j.cclet.2024.110302
6. [6]
  Yuqing Ding , Zhiying Yi , Zhihui Wang , Hongyu Chen , Yan Zhao . Liquid nitrogen post-treatment for improved aggregation and electrical properties in organic semiconductors. Chinese Chemical Letters, 2024, 35(12): 109918-. doi: 10.1016/j.cclet.2024.109918
7. [7]
  Feng Wu , Xuemin Kong , Yixuan Liu , Shuli Wang , Zhong Chen , Xu Hou . Microfluidic-based isolation of circulating tumor cells with high-efficiency and high-purity. Chinese Chemical Letters, 2024, 35(8): 109754-. doi: 10.1016/j.cclet.2024.109754
8. [8]
  Chenlu Huang , Xinyu Yang , Qingyu Yu , Linhua Zhang , Dunwan Zhu . Gas-generating polymersomes-based amplified photoimmunotherapy for abscopal effect and tumor metastasis inhibition. Chinese Chemical Letters, 2024, 35(6): 109680-. doi: 10.1016/j.cclet.2024.109680
9. [9]
  Dan-Ying Xing , Xiao-Dan Zhao , Chuan-Shu He , Bo Lai . Kinetic study and DFT calculation on the tetracycline abatement by peracetic acid. Chinese Chemical Letters, 2024, 35(9): 109436-. doi: 10.1016/j.cclet.2023.109436
10. [10]
  Xiumei LI , Yanju HUANG , Bo LIU , Yaru PAN . Syntheses, crystal structures, and quantum chemistry calculation of two Ni(Ⅱ) coordination polymers. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 2031-2039. doi: 10.11862/CJIC.20240109
11. [11]
  Junqing Wu , Yiyang Zhang , Qingqing Hong , Hui Yang , Lifeng Zhang , Ming Zhang , Lei Yu . Organometallic modification of silica with europium endowing the fluorescence properties: The key technique for numerical quality monitoring. Chinese Chemical Letters, 2025, 36(4): 110165-. doi: 10.1016/j.cclet.2024.110165
12. [12]
  Yixin Zhang , Ting Wang , Jixiang Zhang , Pengyu Lu , Neng Shi , Liqiang Zhang , Weiran Zhu , Nongyue He . Formation mechanism for stable system of nanoparticle/protein corona and phospholipid membrane. Chinese Chemical Letters, 2024, 35(4): 108619-. doi: 10.1016/j.cclet.2023.108619
13. [13]
  Wenlong Li , Feishi Shan , Qingdong Bao , Qinghua Li , Hua Gao , Leyong Wang . Supramolecular assembly nanoparticle for trans-epithelial treatment of keratoconus. Chinese Chemical Letters, 2024, 35(10): 110060-. doi: 10.1016/j.cclet.2024.110060
14. [14]
  Lili Zhang , Hui Gao , Gong Zhang , Yuning Dong , Kai Huang , Zifan Pang , Tuo Wang , Chunlei Pei , Peng Zhang , Jinlong Gong . Cross-section design of the flow channels in membrane electrode assembly electrolyzer for CO₂ reduction reaction through numerical simulations. Chinese Chemical Letters, 2025, 36(1): 110204-. doi: 10.1016/j.cclet.2024.110204
15. [15]
  Maitri Bhattacharjee , Rekha Boruah Smriti , R. N. Dutta Purkayastha , Waldemar Maniukiewicz , Shubhamoy Chowdhury , Debasish Maiti , Tamanna Akhtar . Synthesis, structural characterization, bio-activity, and density functional theory calculation on Cu(Ⅱ) complexes with hydrazone-based Schiff base ligands. Chinese Journal of Inorganic Chemistry, 2024, 40(7): 1409-1422. doi: 10.11862/CJIC.20240007
16. [16]
  Botao QU , Qian WANG , Xiaogang NING , Yuxin ZHOU , Ruiping ZHANG . Deeply penetrating photoacoustic imaging in tumor tissues based on dual-targeted melanin nanoparticle. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 1025-1032. doi: 10.11862/CJIC.20230416
17. [17]
  Shenglan Zhou , Haijian Li , Hongyi Gao , Ang Li , Tian Li , Shanshan Cheng , Jingjing Wang , Jitti Kasemchainan , Jianhua Yi , Fengqi Zhao , Wengang Qu . Recent advances in metal-loaded MOFs photocatalysts: From single atom, cluster to nanoparticle. Chinese Chemical Letters, 2025, 36(1): 110142-. doi: 10.1016/j.cclet.2024.110142
18. [18]
  Xueqi Zhang , Han Gao , Jianan Xu , Min Zhou . Polyelectrolyte-functionalized carbon nanocones enable rapid and accurate analysis of Ag nanoparticle colloids. Chinese Chemical Letters, 2025, 36(4): 110148-. doi: 10.1016/j.cclet.2024.110148
19. [19]
  Xin Lu , Haoran Sun , Xiaomeng Li , Chunrui Li , Jinfeng Wang , Dandan Zhou . C14-HSL limits the mycelial morphology of pathogen Trichosporon cells but enhances their aggregation: Mechanisms and implications. Chinese Chemical Letters, 2024, 35(6): 108936-. doi: 10.1016/j.cclet.2023.108936
20. [20]
  Shuo Li , Qianfa Liu , Lijun Mao , Xin Zhang , Chunju Li , Da Ma . Benzothiadiazole-based water-soluble macrocycle: Synthesis, aggregation-induced emission and selective detection of spermine. Chinese Chemical Letters, 2024, 35(11): 109791-. doi: 10.1016/j.cclet.2024.109791

Get Citation

PDF

XML

Metrics

PDF Downloads(2)
Abstract views(360)
HTML views(15)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142