Citation: Chaoyue Chen, Zheng-Bin Tang, Zhichang Liu. Recent advances in the synthesis and applications of furocoumarin derivatives[J]. Chinese Chemical Letters, ;2023, 34(9): 108396. doi: 10.1016/j.cclet.2023.108396 shu

Recent advances in the synthesis and applications of furocoumarin derivatives

Chaoyue Chen ^{a, *,} ,
Zheng-Bin Tang ^b ,
Zhichang Liu ^{b, *,}

a.
School of Chemistry and Chemical Engineering, Jiangsu University of Technology, Changzhou 213001, China
b.
Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province, Department of Chemistry, School of Science and Research Center for Industries of the Future, Westlake University, and Westlake Institute for Advanced Study, Hangzhou 310030, China

njuchaoyuechen@163.com

liu@westlake.edu.cn

Received Date: 6 February 2023
Revised Date: 21 March 2023
Accepted Date: 28 March 2023
Available Online: 30 March 2023

Figures(20)

Furocoumarins are an important class of heterocyclic compounds with a fused tricyclic structure of coumarin and furan rings. They are commonly found in bioactive natural products and have a diverse range of biological and pharmaceutical properties, including cytotoxicity, photosensitivity, insecticidal, antibacterial, and antifungal activity, among others. The elegant linear/angular tricyclic skeleton and superior pharmacological properties, make them ideal for building and developing advanced biological scaffolds for biomedical applications. As a result, the family of furocoumarins has been the focus of intensive research, and lots of encouraging progress have been achieved in recent years. This review summarizes the most recent methods reported for the synthesis of the furocoumarin derivative family, along with their applications in medicinal chemistry covering from 2018 to 2022.
- Furocoumarin,
- Coumarin,
- Furan,
- Synthesis,
- Pharmaceutical activity,
- Applications
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沈阳化工大学材料科学与工程学院沈阳 110142