Citation: Fangfei Hu, Jianping Qi, Yi Lu, Haisheng He, Wei Wu. PLGA-based implants for sustained delivery of peptides/proteins: Current status, challenge and perspectives[J]. Chinese Chemical Letters, ;2023, 34(11): 108250. doi: 10.1016/j.cclet.2023.108250 shu

PLGA-based implants for sustained delivery of peptides/proteins: Current status, challenge and perspectives

Fangfei Hu ^a ,
Jianping Qi ^{a, b} ,
Yi Lu ^{a, b, c} ,
Haisheng He ^{a, *,} ,
Wei Wu ^{a, b, c, d}

a.
Key Laboratory of Smart Drug Delivery of MOE, School of Pharmacy, Fudan University, Shanghai 201203, China
b.
Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, China
c.
Fudan Zhangjiang Institute, Shanghai 201203, China
d.
Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, China

he_haisheng@fudan.edu.cn

Received Date: 9 December 2022
Revised Date: 16 February 2023
Accepted Date: 21 February 2023
Available Online: 24 February 2023

Figures(6)

Peptide and protein drugs with therapeutic effects suffer from their short half-life and low stability, albeit their high efficiency and specificity. To overcome these demerits, long-acting drug delivery systems have been developed, wherein poly(lactic-co-glycolic acid) (PLGA) implants are most preferred owing to their excellent biodegradability and biocompatibility. Dozens of PLGA based products have been approved since 1986, when the first product, named Decapeptyl^®, successfully marched into market. To meet the increasing demand for delivering various peptides and proteins, different kinds of technologies have been developed for lab-scale fabrication or industrial manufacture. This review aims to introduce recent advances of PLGA implants, and give a brief summary of fundamental properties of PLGA, fabrication technologies of peptides/proteins-loaded PLGA implants as well as factors influencing the drug release processes. Moreover, challenges and future perspectives are also highlighted.
- PLGA,
- Implant,
- Peptide/protein delivery,
- Fabrication technology,
- Drug release
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沈阳化工大学材料科学与工程学院沈阳 110142