Citation: Wenyan Yu, Enpeng Gong, Bingbing Liu, Lei Zhou, Chengyuan Che, Shu Hu, Zhenzhong Zhang, Junjie Liu, Jinjin Shi. Hydrogel-mediated drug delivery for treating stroke[J]. Chinese Chemical Letters, ;2023, 34(9): 108205. doi: 10.1016/j.cclet.2023.108205 shu

Hydrogel-mediated drug delivery for treating stroke

Wenyan Yu ^{a, b, c} ,
Enpeng Gong ^a ,
Bingbing Liu ^a ,
Lei Zhou ^a ,
Chengyuan Che ^a ,
Shu Hu ^a ,
Zhenzhong Zhang ^{a, b, c, *,} ,
Junjie Liu ^{a, b, c, *,} ,
Jinjin Shi ^{a, b, c, *,}

a.
School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China
b.
Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, Zhengzhou 450001, China
c.
Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou 450001, China

zzuzhangzhenzhong@163.com

liujunjie@zzu.edu.cn

shijinyxy@zzu.edu.cn

Received Date: 17 November 2022
Revised Date: 2 February 2023
Accepted Date: 8 February 2023
Available Online: 10 February 2023

Figures(7)

Stroke is a common disease and is the major cause of death and disability. It occurs and generates devastating neurological deficits when cerebral blood vessel is blocked (ischemic stroke, IS) or ruptured (hemorrhagic stroke, HS). Hydrogel, being biodegradable and biocompatible, have shown attractive advantages in stroke therapy as a new biomaterial with desirable mechanical properties and tunability of structure, owing to special ability to load different cargoes for multiple treatment strategies, such as pharmacotherapy based on drug-delivery systems and cell therapy including mesenchymal stem cells (MSCs) and neural progenitor cells (NPCs) for improving functional outcomes. However, a comprehensive review of the functional hydrogel for treatment of stroke is still lacking. Therefore, in this work, the main pathological mechanisms of stroke including IS and HS are comprehensively described. The benefits of hydrogel for stroke treatment are also summarized regarding the natural advantages and the delivery advantages. Simultaneously, the application development of hydrogel for treatment of stroke is highlighted. Finally, the unique considerations and challenges in the design and application of hydrogel is discussed for treatment of stroke and clinical application in the future.
- Drug delivery,
- Functional hydrogel,
- Stroke therapy,
- Bioactive biomaterials,
- Biological applications
1. [1]
  M.P. Lindsay, B. Norrving, R.L. Sacco, et al., Int. J. Stroke 14 (2019) 806–817. doi: 10.1177/1747493019881353
2. [2]
  B.C.V. Campbell, P. Khatri, Lancet 396 (2020) 129–142. doi: 10.1016/S0140-6736(20)31179-X
3. [3]
  Y. Chen, Z. Cai, Z. Ke, Neurologist 22 (2017) 120–126. doi: 10.1097/NRL.0000000000000136
4. [4]
  G.Y. Sun, L.A. Horrocks, A.A. Farooqui, J. Neurochem. 103 (2007) 1–16. doi: 10.1111/j.1471-4159.2007.05003.x
5. [5]
  J. Cao, P. Yan, Y. Zhou, et al., Front. Neurol. 12 (2021) 642483. doi: 10.3389/fneur.2021.642483
6. [6]
  A. Bustamante, B. Diaz-Fernandez, D. Giralt, et al., Int. J. Stroke 11 (2016) 646–655. doi: 10.1177/1747493016641949
7. [7]
  J.L. Frost, D.P. Schafer, Trends Cell Biol. 26 (2016) 587–597. doi: 10.1016/j.tcb.2016.02.006
8. [8]
  Y. Tang, W. Le, Mol. Neurobiol. 53 (2016) 1181–1194. doi: 10.1007/s12035-014-9070-5
9. [9]
  F. Xia, R.F. Keep, F. Ye, et al., Transl. Stroke Res. 13 (2022) 655–664. doi: 10.1007/s12975-021-00980-8
10. [10]
  S. Ma, B. Yu, X. Pei, F. Zhou, Polymer 98 (2016) 516–535. doi: 10.1016/j.polymer.2016.06.053
11. [11]
  W. Sun, T. Incitti, C. Migliaresi, et al., J. Tissue Eng. Regen. Med. 11 (2017) 1532–1541. doi: 10.1002/term.2053
12. [12]
  C. Li, F. Nie, X. Liu, et al., ACS Appl. Mater. Interfaces 13 (2021) 45224–45235. doi: 10.1021/acsami.1c11349
13. [13]
  V.F. Segers, T. Tokunou, L.J. Higgins, et al., Circulation 116 (2007) 1683–1692. doi: 10.1161/CIRCULATIONAHA.107.718718
14. [14]
  S. Lindsey, J.H. Piatt, P. Worthington, et al., Biomacromolecules 16 (2015) 2672–2683. doi: 10.1021/acs.biomac.5b00541
15. [15]
  G. Pan, Q. Mou, Y. Ma, et al., ACS Appl. Mater. Interfaces 11 (2019) 41082–41090. doi: 10.1021/acsami.9b14892
16. [16]
  Y. Huang, W. Xu, G. Liu, L. Tian, Chem. Commun. (Camb) 53 (2017) 3038–3041. doi: 10.1039/C7CC00636E
17. [17]
  B. Xiang, K. He, R. Zhu, et al., ACS Appl. Mater. Interfaces 8 (2016) 22801–22807. doi: 10.1021/acsami.6b03572
18. [18]
  Y. Tan, Y. Li, Y.X. Qu, et al., ACS Appl. Mater. Interfaces 13 (2021) 9436–9444. doi: 10.1021/acsami.0c18282
19. [19]
  M.S. Bae, D.H. Yang, J.B. Lee, et al., Biomaterials 32 (2011) 8161–8171. doi: 10.1016/j.biomaterials.2011.07.045
20. [20]
  J. Xu, Z. Duan, X. Qi, et al., Front. Bioeng. Biotechnol. 8 (2020) 785. doi: 10.1007/s00344-019-10022-1
21. [21]
  G. Singh, A. Nayal, S. Malhotra, V. Koul, Carbohydr. Polym. 247 (2020) 116757. doi: 10.1016/j.carbpol.2020.116757
22. [22]
  Y. Li, Y. Han, X. Wang, et al., ACS Appl. Mater. Interfaces 9 (2017) 16054–16062. doi: 10.1021/acsami.7b04801
23. [23]
  S.J. Buwalda, T. Vermonden, W.E. Hennink, Biomacromolecules 18 (2017) 316–330. doi: 10.1021/acs.biomac.6b01604
24. [24]
  T.R. Hoare, D.S. Kohane, Polymer 49 (2008) 1993–2007. doi: 10.1016/j.polymer.2008.01.027
25. [25]
  Y.S. Zhang, A. Khademhosseini, Science 356 (2017) eaaf3627. doi: 10.1126/science.aaf3627
26. [26]
  S.R. Caliari, J.A. Burdick, Nat. Methods 13 (2016) 405–414. doi: 10.1038/nmeth.3839
27. [27]
  Y.H. Tsou, J. Khoneisser, P.C. Huang, X. Xu, Bioact. Mater. 1 (2016) 39–55. doi: 10.1016/j.bioactmat.2016.05.001
28. [28]
  M.A. Grimaudo, G.S. Krishnakumar, E. Giusto, et al., Acta Biomater. 140 (2022) 88–101. doi: 10.1016/j.actbio.2021.11.038
29. [29]
  N.L. Weilinger, V. Maslieieva, J. Bialecki, et al., Acta Pharmacol. Sin. 34 (2013) 39–48. doi: 10.1038/aps.2012.95
30. [30]
  D. Mayor, M. Tymianski, Neuropharmacology 134 (2018) 178–188. doi: 10.1016/j.neuropharm.2017.11.050
31. [31]
  G.J. Zipfel, J. -M. Lee, D.W. Choi, N. Engl. J. Med. 341 (1999) 1543–1544. doi: 10.1056/NEJM199911113412011
32. [32]
  B. Chen, I.A. Meinertzhagen, S.R. Shaw, J. Comp. Physiol. A 185 (1999) 393–404. doi: 10.1007/s003590050400
33. [33]
  F.J. Bock, S.W.G. Tait, Nat. Rev. Mol. Cell Biol. 21 (2020) 85–100. doi: 10.1038/s41580-019-0173-8
34. [34]
  R. Shakeri, A. Kheirollahi, J. Davoodi, Biochimie 135 (2017) 111–125. doi: 10.1016/j.biochi.2017.02.001
35. [35]
  H. Qi, Y. Jiang, Z. Yin, et al., Phys. Chem. Chem. Phys. 20 (2018) 1964–1973. doi: 10.1039/c7cp06726g
36. [36]
  V. Larosa, C. Remacle, Biosci. Rep. 38 (2018) BSR20171492. doi: 10.1042/BSR20171492
37. [37]
  M. Redza-Dutordoir, D.A. Averill-Bates, Biochim. Biophys. Acta 1863 (2016) 2977–2992. doi: 10.1016/j.bbamcr.2016.09.012
38. [38]
  L.Z. Li, Y.Y. Huang, Z.H. Yang, et al., CNS Neurosci. Ther. 26 (2020) 288–296. doi: 10.1111/cns.13291
39. [39]
  W. Chen, Y. Zhang, X. Zhai, et al., J. Cereb. Blood Flow Metab. 42 (2022) 1579–1596. doi: 10.1177/0271678x221098841
40. [40]
  X. Lan, X. Han, Q. Li, et al., Nat. Rev. Neurol. 13 (2017) 420–433. doi: 10.1038/nrneurol.2017.69
41. [41]
  K. Gertz, G. Kronenberg, R.E. Kalin, et al., Brain 135 (2012) 1964–1980. doi: 10.1093/brain/aws075
42. [42]
  Y. He, Y. Gao, Q. Zhang, et al., Neuroscience 437 (2020) 161–171. doi: 10.1016/j.neuroscience.2020.03.008
43. [43]
  B. Pósfai, C. Cserép, B. Orsolits, Á. Dénes, Neuroscience 405 (2019) 103–117. doi: 10.1016/j.neuroscience.2018.04.046
44. [44]
  C. Limatola, R.M. Ransohoff, Front. Cell. Neurosci. 8 (2014) 229.
45. [45]
  C. Luo, S. Zhou, S. Yin, et al., Front. Mol. Neurosci. 15 (2022) 850849. doi: 10.3389/fnmol.2022.850849
46. [46]
  S.G. Soriano, L.S. Amaravadi, Y.F. Wang, et al., J. Neuroimmunol. 125 (2002) 59–65. doi: 10.1016/S0165-5728(02)00033-4
47. [47]
  M. He, H. Dong, Y. Huang, et al., Cell. Physiol. Biochem. 38 (2016) 859–870. doi: 10.1159/000443040
48. [48]
  R.A. Taylor, M.D. Hammond, Y. Ai, L.H. Sansing, PLoS One 9 (2014) e114472. doi: 10.1371/journal.pone.0114472
49. [49]
  X. Qin, F. Akter, L. Qin, et al., Front. Immunol. 11 (2020) 689. doi: 10.3389/fimmu.2020.00689
50. [50]
  W. He, N. Kapate, C.W. Shields, S. Mitragotri, Adv. Drug Deliv. Re. (2020) 15–40 165-166.
51. [51]
  M. Zoulikha, F. Huang, Z. Wu, W. He, J. Control. Release 346 (2022) 260–274. doi: 10.1016/j.jconrel.2022.04.027
52. [52]
  Q. Xiao, X. Li, Y. Li, et al., Acta Pharm. Sin. B 11 (2021) 941–960. doi: 10.1016/j.apsb.2020.12.018
53. [53]
  C.G. Sobey, Free Radic. Biol. Med. 120 (2018) S6–S23.
54. [54]
  N.S. Jenny, P.W. Callas, S.E. Judd, et al., Neurology 92 (2019) e2375–e2384. doi: 10.1212/wnl.0000000000007416
55. [55]
  H.K. Liew, W.F. Hu, P.B. Lin, et al., Cells 8 (2019) 1326. doi: 10.3390/cells8111326
56. [56]
  Y. Gong, Y. Zhang, S. Feng, et al., FASEB J. 31 (2017) 212–223. doi: 10.1096/fj.201600398rrr
57. [57]
  S. Pitchford, D. Pan, H.C. Welch, Curr. Opin. Hematol. 24 (2017) 23–31. doi: 10.1097/MOH.0000000000000297
58. [58]
  R.L. Manthe, S. Muro, Bioeng. Transl. Med. 2 (2017) 109–119. doi: 10.1002/btm2.10050
59. [59]
  H. Pawluk, A. Wozniak, G. Grzesk, et al., Clin. Interv. Aging 15 (2020) 469–484. doi: 10.2147/cia.s233909
60. [60]
  S. Sanjabi, L.A. Zenewicz, M. Kamanaka, R.A. Flavell, Curr. Opin. Pharmacol. 9 (2009) 447–453. doi: 10.1016/j.coph.2009.04.008
61. [61]
  R.P. Bhusal, S.R. Foster, M.J. Stone, Protein Sci. 29 (2020) 420–432. doi: 10.1002/pro.3744
62. [62]
  M. Minami, M. Satoh, Life Sci. 74 (2003) 321–327. doi: 10.1016/j.lfs.2003.09.019
63. [63]
  G.Y. -Q. Ng, Y. -A. Lim, C.G. Sobey, et al., Ther. Adv. Neuro. Disord. 11 (2018) 1756286418771815.
64. [64]
  K. Shi, D. -C. Tian, Z. -G. Li, et al., Lancet Neurol. 18 (2019) 1058–1066. doi: 10.1016/S1474-4422(19)30078-X
65. [65]
  S. Kimura-Ohba, Y. Yang, Oxid. Med. Cell. Longev. 2016 (2016) 6927328.
66. [66]
  J. Jiang, Y. Yu, Med. Res. Rev. 41 (2021) 828–857. doi: 10.1002/med.21744
67. [67]
  R. Sethi, N. Gomez-Coronado, A.J. Walker, et al., Front. Psychiatry 10 (2019) 605.
68. [68]
  N. Ghazanfari, A. van Waarde, R. Dierckx, et al., J. Neurosci. Res. 99 (2021) 2976–2998. doi: 10.1002/jnr.24934
69. [69]
  A. Sorokin, Curr. Med. Chem. 23 (2016) 2559–2578. doi: 10.2174/0929867323666160729105312
70. [70]
  M. Florczak-Rzepka, C. Grond-Ginsbach, J. Montaner, T. Steiner, Cerebrovasc. Dis. 34 (2012) 249–262. doi: 10.1159/000341686
71. [71]
  B.C. Lund, T.E. Abrams, A.A. Gravely, J. Rehabil. Res. Dev. 48 (2011) 21–30. doi: 10.1682/JRRD.2009.08.0116
72. [72]
  H. Wu, Z. Zhang, Y. Li, et al., Neurochem. Int. 57 (2010) 248–253. doi: 10.1016/j.neuint.2010.06.002
73. [73]
  M. Chaturvedi, L. Kaczmarek, Mol. Neurobiol. 49 (2014) 563–573. doi: 10.1007/s12035-013-8538-z
74. [74]
  E.E. Gardiner, R.K. Andrews, Transfus. Med. Rev. 28 (2014) 56–60. doi: 10.1016/j.tmrv.2014.03.001
75. [75]
  M.C. Berndt, Y. Shen, S.M. Dopheide, et al., Thromb. Haemost. 86 (2001) 178–188. doi: 10.1055/s-0037-1616216
76. [76]
  D. Chen, K.P. Taylor, Q. Hall, J.M. Kaplan, Genetics 204 (2016) 1151–1159. doi: 10.1534/genetics.116.192898
77. [77]
  B.G. Petrich, P. Marchese, Z.M. Ruggeri, et al., J. Exp. Med. 204 (2007) 3103–3111. doi: 10.1084/jem.20071800
78. [78]
  B. Nieswandt, M. Moser, I. Pleines, et al., J. Exp. Med. 204 (2007) 3113–3118. doi: 10.1084/jem.20071827
79. [79]
  V. Duran-Laforet, D. Fernandez-Lopez, A. Garcia-Culebras, et al., Front. Neurosci. 13 (2019) 767. doi: 10.3389/fnins.2019.00767
80. [80]
  H.K. Eltzschig, T. Eckle, Nat. Med. 17 (2011) 1391–1401. doi: 10.1038/nm.2507
81. [81]
  M. Fisher, S.I. Savitz, Nat. Rev. Neurol. 18 (2022) 193–202. doi: 10.1038/s41582-021-00605-6
82. [82]
  M.S. Sun, H. Jin, X. Sun, et al., Oxid. Med. Cell. Longev. 2018 (2018) 3804979.
83. [83]
  C. Farah, L.Y.M. Michel, J.L. Balligand, Nat. Rev. Cardiol. 15 (2018) 292–316. doi: 10.1038/nrcardio.2017.224
84. [84]
  E. Bayir, A. Sendemir, Cells 10 (2021) 1400. doi: 10.3390/cells10061400
85. [85]
  J. Wu, Y. Hua, R.F. Keep, et al., Stroke 34 (2003) 2964–2969. doi: 10.1161/01.STR.0000103140.52838.45
86. [86]
  G. Xi, R.F. Keep, J.T. Hoff, Lancet Neurol. 5 (2006) 53–63. doi: 10.1016/S1474-4422(05)70283-0
87. [87]
  G. Xi, Y. Hua, R.R. Bhasin, et al., Stroke 32 (2001) 2932–2938. doi: 10.1161/hs1201.099820
88. [88]
  D. Bulters, B. Gaastra, A. Zolnourian, et al., Nat. Rev. Neurol. 14 (2018) 416–432. doi: 10.1038/s41582-018-0020-0
89. [89]
  M.S. Kwon, S.K. Woo, D.B. Kurland, et al., Int. J. Mol. Sci. 16 (2015) 5028–5046. doi: 10.3390/ijms16035028
90. [90]
  K.R. Wagner, F.R. Sharp, T.D. Ardizzone, et al., J. Cereb. Blood Flow Metab. 23 (2003) 629–652. doi: 10.1097/01.WCB.0000073905.87928.6D
91. [91]
  Y. Wei, X. Song, Y. Gao, et al., Brain Res. Bull. 178 (2022) 144–154. doi: 10.1016/j.brainresbull.2021.11.014
92. [92]
  S. Khan, A. Ullah, K. Ullah, N.U. Rehman, Des. Monomers Polym. 19 (2016) 456–478. doi: 10.1080/15685551.2016.1169380
93. [93]
  U.S.K. Madduma-Bandarage, S.V. Madihally, J. Appl. Polym. Sci. 138 (2020) e50376.
94. [94]
  M.T. Spang, K.L. Christman, Acta Biomater. 68 (2018) 1–14. doi: 10.1016/j.actbio.2017.12.019
95. [95]
  V.A. Kornev, E.A. Grebenik, A.B. Solovieva, et al., Comput. Struct. Biotechnol. J. 16 (2018) 488–502. doi: 10.1016/j.csbj.2018.10.011
96. [96]
  N.K. Karamanos, A.D. Theocharis, Z. Piperigkou, et al., FEBS J. 288 (2021) 6850–6912. doi: 10.1111/febs.15776
97. [97]
  H. Ghuman, A.R. Massensini, J. Donnelly, et al., Biomaterials 91 (2016) 166–181. doi: 10.1016/j.biomaterials.2016.03.014
98. [98]
  Y. Wu, J. Wang, Y. Shi, et al., Cell Transplant. 26 (2017) 1224–1234. doi: 10.1177/0963689717714090
99. [99]
  K. Saha, A.J. Keung, E.F. Irwin, et al., Biophys. J. 95 (2008) 4426–4438. doi: 10.1529/biophysj.108.132217
100. [100]
  A.J. Engler, S. Sen, H.L. Sweeney, D.E. Discher, Cell 126 (2006) 677–689. doi: 10.1016/j.cell.2006.06.044
101. [101]
  N. Oliva, J. Conde, K. Wang, N. Artzi, Acc. Chem. Res. 50 (2017) 669–679. doi: 10.1021/acs.accounts.6b00536
102. [102]
  J. Li, D.J. Mooney, Nat. Rev. Mater. 1 (2016) 16071. doi: 10.1038/natrevmats.2016.71
103. [103]
  C.C. Lin, A.T. Metters, Adv. Drug Deliv. Rev. 58 (2006) 1379–1408. doi: 10.1016/j.addr.2006.09.004
104. [104]
  L. Zhao, L. Zhu, F. Liu, et al., Int. J. Pharm. 410 (2011) 83–91. doi: 10.1016/j.ijpharm.2011.03.034
105. [105]
  S.J. Chan, C. Love, M. Spector, et al., Neurochem. Int. 107 (2017) 57–65. doi: 10.1016/j.neuint.2017.03.024
106. [106]
  D.J. Cook, C. Nguyen, H.N. Chun, et al., J. Cereb. Blood Flow Metab. 37 (2017) 1030–1045. doi: 10.1177/0271678X16649964
107. [107]
  S. Correa, A.K. Grosskopf, H. Lopez Hernandez, et al., Chem. Rev. 121 (2021) 11385–11457. doi: 10.1021/acs.chemrev.0c01177
108. [108]
  L. Cai, S.C. Heilshorn, Acta Biomater. 10 (2014) 1751–1760. doi: 10.1016/j.actbio.2013.12.028
109. [109]
  L. Fu, M. Suflita, R.J. Linhardt, Adv. Drug Deliv. Rev. 97 (2016) 237–249. doi: 10.1016/j.addr.2015.11.002
110. [110]
  A. Nilasaroya, A.M. Kop, D.A. Morrison, J. Biomed. Mater. Res. A 109 (2021) 374–384. doi: 10.1002/jbm.a.37030
111. [111]
  Y.J. Park, C.V. Borlongan, J. Cereb. Blood Flow Metab. 41 (2021) 2797–2799. doi: 10.1177/0271678x211026507
112. [112]
  S. Yin, Y. Cao, Acta Biomater. 128 (2021) 1–20. doi: 10.1016/j.actbio.2021.03.026
113. [113]
  F.J. Vernerey, S. Lalitha Sridhar, A. Muralidharan, S.J. Bryant, Chem. Rev. 121 (2021) 11085–11148. doi: 10.1021/acs.chemrev.1c00046
114. [114]
  C. Qin, S. Yang, Y.H. Chu, et al., Signal Transduct. Target. Ther. 7 (2022) 215. doi: 10.1038/s41392-022-01064-1
115. [115]
  D. Lyu, S. Chen, W. Guo, Small 14 (2018) e1704039. doi: 10.1002/smll.201704039
116. [116]
  J. Li, Q. Tian, H. Sun, et al., Mater. Today Nano 20 (2022) 100264. doi: 10.1016/j.mtnano.2022.100264
117. [117]
  Y. Ni, W. Zhao, W. Cheng, et al., J. Control. Release 351 (2022) 245–254. doi: 10.1016/j.jconrel.2022.09.014
118. [118]
  Y. He, W. Zhang, Q. Xiao, et al., Asian J. Pharm. Sci. 17 (2022) 817–837. doi: 10.1016/j.ajps.2022.11.002
119. [119]
  X. Qin, Y. Xu, X. Zhou, et al., Acta Pharm. Sin. B 11 (2021) 835–847. doi: 10.1016/j.apsb.2020.10.016
120. [120]
  H.J. Yoon, S. Lee, T.Y. Kim, et al., Bioact. Mater. 18 (2022) 433–445. doi: 10.1016/j.bioactmat.2022.03.031
121. [121]
  Q. Zhao, J. Liu, S. Liu, et al., ACS Appl. Mater. Interfaces 14 (2022) 46224–46238. doi: 10.1021/acsami.2c12530
122. [122]
  Y. Cai, J. Qi, Y. Lu, et al., Adv. Drug Deliv. Rev. 188 (2022) 114463. doi: 10.1016/j.addr.2022.114463
123. [123]
  K. Thapa Magar, G.F. Boafo, X. Li, et al., Chin. Chem. Lett. 33 (2022) 587–596. doi: 10.1016/j.cclet.2021.08.020
124. [124]
  Z. Zhao, X. Fan, S. Wang, et al., Chin. Chem. Lett. 34 (2023) 107892. doi: 10.1016/j.cclet.2022.107892
125. [125]
  Y. Pan, Y. Xiao, Y. Hao, et al., Chin. Chem. Lett. 33 (2022) 2486–2490. doi: 10.1016/j.cclet.2021.12.093
126. [126]
  X. Hao, X. Zhang, Y. Hu, et al., Chin. Chem. Lett. 34 (2023) 107965. doi: 10.1016/j.cclet.2022.107965
127. [127]
  C.C. Esenwa, M.S. Elkind, Nat. Rev. Neurol. 12 (2016) 594–604. doi: 10.1038/nrneurol.2016.125
128. [128]
  X. Du, J. Zhou, J. Shi, B. Xu, Chem. Rev. 115 (2015) 13165–13307. doi: 10.1021/acs.chemrev.5b00299
129. [129]
  Y. Liu, F. Zhang, L. Long, et al., Chem. Eng. J. 433 (2022) 133671. doi: 10.1016/j.cej.2021.133671
130. [130]
  A. Tuladhar, J.M. Obermeyer, S.L. Payne, et al., Biomaterials 235 (2020) 119794. doi: 10.1016/j.biomaterials.2020.119794
131. [131]
  H. Kang, S.H.D. Wong, Q. Pan, et al., Nano Lett. 19 (2019) 1963–1975. doi: 10.1021/acs.nanolett.8b05150
132. [132]
  W.C. Hsieh, C.P. Chang, S.M. Lin, Colloids Surf. B Biointerfaces 57 (2007) 250–255. doi: 10.1016/j.colsurfb.2007.02.004
133. [133]
  N. Gorenkova, I. Osama, F.P. Seib, H.V.O. Carswell, ACS Biomater. Sci. Eng. 5 (2019) 859–869. doi: 10.1021/acsbiomaterials.8b01024
134. [134]
  Y.W. Tao, L. Yang, S.Y. Chen, et al., J. Ethnopharmacol. 294 (2022) 115316. doi: 10.1016/j.jep.2022.115316
135. [135]
  P. Liu, C. Jiang, Wiley. Interdiscip. Rev. Nanomed. Nanobiotechnol. 14 (2022) e1818. doi: 10.1002/wnan.1818
136. [136]
  C. Wang, R.R. Varshney, D.A. Wang, Adv. Drug Deliv. Rev. 62 (2010) 699–710. doi: 10.1016/j.addr.2010.02.001
137. [137]
  W.H. Jian, H.C. Wang, C.H. Kuan, et al., Biomaterials 174 (2018) 17–30. doi: 10.1016/j.biomaterials.2018.05.009
138. [138]
  J. Wang, X. Li, Y. Song, et al., Bioact. Mater. 6 (2021) 1988–1999. doi: 10.1016/j.bioactmat.2020.12.017
139. [139]
  K. Fu, H. Wu, Z. Su, Biotechnol. Adv. 49 (2021) 107752. doi: 10.1016/j.biotechadv.2021.107752
140. [140]
  A. Farrukh, F. Ortega, W. Fan, et al., Stem Cell Rep. 9 (2017) 1432–1440. doi: 10.1016/j.stemcr.2017.09.002
141. [141]
  Y. Sun, W. Li, X. Wu, et al., ACS Appl. Mater. Interfaces 8 (2016) 2348–2359. doi: 10.1021/acsami.5b11473
142. [142]
  S.T. Carmichael, Ann. Neurol. 59 (2006) 735–742. doi: 10.1002/ana.20845
143. [143]
  M. Kanazawa, T. Takahashi, M. Ishikawa, et al., J. Cereb. Blood Flow Metab. 39 (2019) 753–769. doi: 10.1177/0271678x19834158
144. [144]
  Y. Ma, S. Yang, Q. He, et al., Front. Immunol. 12 (2021) 784098. doi: 10.3389/fimmu.2021.784098
145. [145]
  R. Ju, Y. Wen, R. Gou, et al., Cell Transplant. 23 (Suppl. 1) (2014) S83–S95.
146. [146]
  L.R. Nih, S. Gojgini, S.T. Carmichael, T. Segura, Nat. Mater. 17 (2018) 642–651. doi: 10.1038/s41563-018-0083-8
147. [147]
  M.R. McCrary, K. Jesson, Z.Z. Wei, et al., Adv. Healthc. Mater. 9 (2020) e1900285. doi: 10.1002/adhm.201900285
148. [148]
  M. Qu, J. Pan, L. Wang, et al., Mol. Ther. Nucleic. Acids 16 (2019) 15–25. doi: 10.1016/j.omtn.2019.02.002
149. [149]
  A.D. Li, L. Tong, N. Xu, et al., Brain Res. Bull. 153 (2019) 214–222. doi: 10.3390/fi11100214
150. [150]
  Y. Esparza, N. Bandara, A. Ullah, J. Wu, Mater. Sci. Eng. C 90 (2018) 446–453. doi: 10.1016/j.msec.2018.04.067
151. [151]
  Y. He, Q. Qu, T. Luo, et al., ACS Biomater. Sci. Eng. 5 (2019) 1113–1122. doi: 10.1021/acsbiomaterials.8b01609
152. [152]
  T. Luo, T. Guo, Q. Yang, et al., Int. J. Pharm. 534 (2017) 179–189. doi: 10.1016/j.ijpharm.2017.10.010
153. [153]
  Q. Zhu, Y. Gong, T. Guo, et al., Int. J. Pharm. 566 (2019) 342–351. doi: 10.1016/j.ijpharm.2019.05.076
154. [154]
  O. Adeoye, J.P. Broderick, Nat. Rev. Neurol. 6 (2010) 593–601. doi: 10.1038/nrneurol.2010.146
155. [155]
  L. Wang, S. Luo, S. Ren, et al., Front. Neurol. 13 (2022) 727702. doi: 10.3389/fneur.2022.727702
156. [156]
  F. Rizzo, N.S. Kehr, Adv. Healthc. Mater. 10 (2021) e2001341. doi: 10.1002/adhm.202001341
157. [157]
  L.R. Nih, S.T. Carmichael, T. Segura, Curr. Opin. Biotechnol. 40 (2016) 155–163. doi: 10.1016/j.copbio.2016.04.021
158. [158]
  S. Budday, G. Sommer, C. Birkl, et al., Acta Biomater. 48 (2017) 319–340. doi: 10.1016/j.actbio.2016.10.036
159. [159]
  A.I. Teixeira, S. Ilkhanizadeh, J.A. Wigenius, et al., Biomaterials 30 (2009) 4567–4572. doi: 10.1016/j.biomaterials.2009.05.013
160. [160]
  S. Reis-Dennis, Monash Bioeth. Rev. 38 (2020) 83–86. doi: 10.1007/s40592-020-00107-z
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