Citation: Yan Dong, Xicun Lu, Yi Li, Weichao Chen, Lei Yin, Jie Zhao, Xinru Hu, Xinran Li, Zuhai Lei, Yuyang Wu, Hao Chen, Xiao Luo, Xuhong Qian, Youjun Yang. Spectral and biodistributional engineering of deep near-infrared chromophore[J]. Chinese Chemical Letters, ;2023, 34(9): 108154. doi: 10.1016/j.cclet.2023.108154 shu

Spectral and biodistributional engineering of deep near-infrared chromophore

Yan Dong ^a ,
Xicun Lu ^a ,
Yi Li ^a ,
Weichao Chen ^a ,
Lei Yin ^a ,
Jie Zhao ^a ,
Xinru Hu ^a ,
Xinran Li ^a ,
Zuhai Lei ^a ,
Yuyang Wu ^c ,
Hao Chen ^c ,
Xiao Luo ^{a, b} ,
Xuhong Qian ^{a, b} ,
Youjun Yang ^{a, *,}

a.
State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
b.
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, China
c.
Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

youjunyang@ecust.edu.cn

Received Date: 7 January 2023
Revised Date: 12 January 2023
Accepted Date: 13 January 2023
Available Online: 15 January 2023

Figures(6)

Fluorescence-guided surgery calls for development of near-infrared fluorophores. Despite the wide-spread application and a safe clinical record of Indocyanine Green (ICG), its maximal absorption wavelength at 780 nm is rather short and longer-wavelength dyes are desired to exploit such benefits as low photo-toxicity and deep penetration depth. Here, we report ECY, a stable deep near-infrared (NIR) fluorochromic scaffold absorbing/emitting at 836/871 nm with a fluorescence quantum yield of 16% in CH₂Cl₂. ECY was further rationally engineered for biological distribution specificity. Analogous bearing different numbers of sulfonate group or a polyethylene glycol chain were synthesized. By screening this focused library upon intravenous injection to BALB/c mice, ECYS2 was identified to be a suitable candidate for bioimaging of organs involved in hepatobiliary excretion, and ECYPEG was found to be a superior candidate for vasculature imaging. They have potentials in intraoperative imaging.
- Near infrared fluorophore,
- In vivo imaging,
- Molecular engineering,
- Biological distribution,
- Angiography
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