Citation: Yiming Wu, Zhe Zhang, Yuquan Wei, Zhiyong Qian, Xiawei Wei. Nanovaccines for cancer immunotherapy: Current knowledge and future perspectives[J]. Chinese Chemical Letters, ;2023, 34(8): 108098. doi: 10.1016/j.cclet.2022.108098 shu

Nanovaccines for cancer immunotherapy: Current knowledge and future perspectives

Laboratory of Aging Research and Cancer Drug Target, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, China

anderson-qian@163.com

xiaweiwei@scu.edu.cn

Received Date: 6 September 2022
Revised Date: 20 December 2022
Accepted Date: 22 December 2022
Available Online: 27 December 2022

Figures(4)

Cancer immunotherapy harnesses the immune system to attack tumors and has received extensive attention in recent years. Cancer vaccines as an important branch of immunotherapy are designed for delivering tumor antigens to antigen-presenting cells (APCs) to stimulate a strong immune response to against tumors, representing a potentially therapeutic and prophylactic effect with the long-term anti-cancer benefits. Nevertheless, the disappointing outcomes of their clinical use might be attributed to dilemma in antigen selection, immunogenicity, lymph nodes (LNs) targeting ability, lysosomal escape ability, immune evasion, etc. Nanotechnology, aiming to overcome these barriers, has been utilized in cancer vaccine development for decades. Numerous preclinical and clinical studies demonstrate positive results in nanomaterials-based cancer vaccines with considerable improvement in the vaccine efficacy. In this review, we systematically introduced the characteristics of nanovaccines and highlighted the different types of nanomaterials used for cancer vaccine design. In addition, the opportunities and challenges of the emerging nanotechnology-based cancer vaccines were discussed.
- Cancer immunotherapy,
- Cancer vaccines,
- Nanoparticles,
- Antitumor immune response,
- Clinical transformation
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