Citation: Chenlu He, Yan Li. Absolute asymmetric synthesis driven by circularly polarized light[J]. Chinese Chemical Letters, ;2023, 34(8): 108077. doi: 10.1016/j.cclet.2022.108077 shu

Absolute asymmetric synthesis driven by circularly polarized light

Chenlu He ^{a, b} ,
Yan Li ^{a, *,}

a.
School of Pharmacy and Pharmaceutical Science and Institute of Materia Medica, Shandong First Medical University, Shandong Academy of Medical Sciences, NHC Key Laboratory of Biotechnology Drugs (Shandong Academy of Medical Sciences), Key Lab for Rare and Uncommon Diseases of Shandong Province, Ji'nan 250117, China
b.
Department of Chemistry, National University of Singapore (NUS), Singapore 117549, Singapore

liyann@sdfmu.edu.cn

Received Date: 21 September 2022
Revised Date: 22 November 2022
Accepted Date: 14 December 2022
Available Online: 16 December 2022

Figures(11)

Circularly polarized light (CPL) is an inherently chiral entity and is regarded as one of the possible deterministic signals that led to the evolution of homochirality in earth. Thus, CPL as an external physical field has been widely used in a technique known as absolute asymmetric synthesis, because a product enriched in one enantiomer is formed from racemic precursor molecules without the intervention of a chiral catalyst. In this review, we retrospect the historical research of CPL-induced absolute asymmetric synthesis, including chiral organic molecules, helical polymers, supramolecular assemblies, noble metal nanostructures. However, based on these results, we concluded that the chiral photon-matter interaction is very faint due to the arrangement of molecular bonds giving rise to chiral features, is over a smaller distance than the helical pitch of CPL, leading extremely small enantiomeric excess for product. Therefore, we highlight the recently emerged technology called superchiral field, in which the superchiral far-field and near-field could enhance the dissymmetry of optical field and near-field, respectively. In sum, we hope this review could bring some enlightenment to researchers and further improve the enantioselectivity of CPL-induced absolute asymmetric synthesis.
- Asymmetric synthesis,
- Circularly polarized light,
- Photochemical reaction,
- Chirality,
- Superchiral fields
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