Citation: Qihui Wang, Jiayi Luan, Zhilong Zhao, Weihui Kong, Congxiao Zhang, Jianxun Ding. Dentin-desensitizing biomaterials[J]. Chinese Chemical Letters, ;2023, 34(8): 108060. doi: 10.1016/j.cclet.2022.108060 shu

Dentin-desensitizing biomaterials

Qihui Wang ^{a, b} ,
Jiayi Luan ^{b, c} ,
Zhilong Zhao ^a ,
Weihui Kong ^a ,
Congxiao Zhang ^{a, *,} ,
Jianxun Ding ^{b, *,}

a.
Department of Stomatology, the First Hospital of Jilin University, Changchun 130061, China
b.
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
c.
VIP Integrated Department, Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, School and Hospital of Stomatology, Jilin University, Changchun 130021, China

zhangcongxiao@jlu.edu.cn

jxding@ciac.ac.cn

Received Date: 15 October 2022
Revised Date: 10 December 2022
Accepted Date: 12 December 2022
Available Online: 14 December 2022

Figures(3)

Dentin hypersensitivity (DH) associated with dentinal tubule exposure is one of the most common causes of toothache with a rapid onset and short duration. Medication, filling repair, laser irradiation, crown therapy, and desensitizing toothpaste are standard clinical treatment strategies, but unsatisfactory treatment modalities are marked by long-term administration, poor dentinal tubule closure, microleakage, and the development of secondary caries. To improve the treatment efficiency of DH, numerous organic or inorganic biomaterials have been developed to relieve toothache and reverse the instability of desensitization. Biomaterials are expected to participate in dental remineralization to achieve desensitization. This review discusses various biomaterials for DH therapy based on different desensitization mechanisms, including dentinal tubule closure and dental nerve blockade, and presents a perspective on the underlying future of dentin regeneration medicine for DH therapy.
- Biomaterial,
- Dentin hypersensitivity,
- Dentinal tubule closure,
- Dental nerve blockade,
- Regenerative medicine
1. [1]
  L.F. Zeola, P.V. Soares, J. Cunha-Cruz, J. Dent. 81 (2019) 1-6. doi: 10.1016/j.jdent.2018.12.015
2. [2]
  K. Bekes, M.T. John, H.G. Schaller, C. Hirsch, J. Oral Rehabil. 36 (2009) 45-51. doi: 10.1111/j.1365-2842.2008.01901.x
3. [3]
  J. Cunha-Cruz, J.C. Wataha, L.J. Heaton, et al., J. Am. Dent. Assoc. 144 (2013) 288-296. doi: 10.14219/jada.archive.2013.0116
4. [4]
  T. Oyama, K. Matsumoto, J. Endod. 17 (1991) 500-502. doi: 10.1016/S0099-2399(06)81798-X
5. [5]
  M.V.O. Närhi, T.J. Hirvonen, M.O.K. Hakumäki, Acta Physiol. Scand. 115 (1982) 173-178. doi: 10.1111/j.1748-1716.1982.tb07062.x
6. [6]
  P.A. Walters, J. Contemp. Dent. Pract. 6 (2005) 107-117. doi: 10.5005/jcdp-6-2-107
7. [7]
  P.L. Jacobsen, G. Bruce, J. Contemp. Dent. Pract. 2 (2001) 1-12. doi: 10.1061/40582(2001)10
8. [8]
  N. Vongsavan, B. Matthews, Arch. Oral Biol. 52 (2007) 640-647. doi: 10.1016/j.archoralbio.2006.12.019
9. [9]
  D. Andrew, B. Matthews, J. Physiol. 529 (2000) 791-802. doi: 10.1111/j.1469-7793.2000.00791.x
10. [10]
  A. Aminoshariae, J.C. Kulild, J. Endod. 47 (2021) 1696-1702. doi: 10.1016/j.joen.2021.07.011
11. [11]
  M.A. Kido, T. Ibuki, A. Danjo, et al., Arch. Histol. Cytol. 68 (2005) 259-265. doi: 10.1679/aohc.68.259
12. [12]
  S. Kim, J. Endod. 16 (1990) 48-53. doi: 10.1016/S0099-2399(06)81563-3
13. [13]
  J. Caviedes-Bucheli, H.R. Muñoz, M.M. Azuero-Holguín, E. Ulate, J. Endod. 34 (2008) 773-788. doi: 10.1016/j.joen.2008.03.010
14. [14]
  S. Maity, V. Priyadharshini, S. Basavaraju, J. Indian Soc. Periodontol. 24 (2020) 441-446. doi: 10.4103/jisp.jisp_500_19
15. [15]
  J. Creeth, J. Gallob, F. Sufi, et al., BMC Oral Health 19 (2019) 1-9. doi: 10.1186/s12903-018-0701-5
16. [16]
  B.K. Yadav, A. Jain, A. Rai, M. Jain, J. Int. Oral Health 7 (2015) 137-143.
17. [17]
  Z.H. Xiong, L. Xia, L. Mei, G.Z. Han, Y.M. Chen, Chin. J. Stomatol. 46 (2011) 214-217.
18. [18]
  F. Femiano, R. Femiano, A. Lanza, et al., Am. J. Dent. 26 (2013) 214-218.
19. [19]
  I. Willershausen, D. Schulte, A. Azaripour, et al., Clin. Lab. 61 (2015) 1695-1701.
20. [20]
  G.G. Craig, G.M. Knight, J.M. McIntyre, Aust. Dent. J. 57 (2012) 308-311. doi: 10.1111/j.1834-7819.2012.01700.x
21. [21]
  A.S. Bakry, H. Takahashi, M. Otsuki, et al., J. Dent. Res. 90 (2011) 246-250. doi: 10.1177/0022034510387793
22. [22]
  K. Ozlem, G.M. Esad, A. Ayse, U. Aslihan, Niger. J. Clin. Pract. 21 (2018) 225-230.
23. [23]
  H. Zhuang, Y. Liang, S. Xiang, et al., J. Appl. Oral Sci. 29 (2021) e20200266. doi: 10.1590/1678-7757-2020-0266
24. [24]
  S. Kurt, T. Kırtıloğlu, N.A. Yılmaz, E. Ertaş, H. Oruçoğlu, Lasers Med. Sci. 33 (2018) 1883-1890. doi: 10.1007/s10103-018-2546-1
25. [25]
  E. Öncü, S. Karabekiroğlu, N. Ünlü, Microsc. Res. Tech. 80 (2017) 737-744. doi: 10.1002/jemt.22859
26. [26]
  J.H. Wang, K. Yang, B. z. Zhang, et al., BMC Oral Health 20 (2020) 1-10. doi: 10.1186/s12903-019-0991-2
27. [27]
  Q.Z. Cui, M.G. Wei, Z.D. Xiong, et al., Photobiomodul. Photomed. Laser Surg. 39: 6 (2020) 390-394. doi: 10.1089/photob.2019.4797
28. [28]
  B.S. Lee, C.W. Chang, W.P. Chen, W.H. Lan, C.P. Lin, Dent. Mater. 21 (2005) 511-519. doi: 10.1016/j.dental.2004.08.002
29. [29]
  V. Maximiano, A.C. Machado, R.M. Lopes, et al., J. Appl. Oral Sci. 29 (2021) e20200736. doi: 10.1590/1678-7757-2020-0736
30. [30]
  A.C. Machado, V. Maximiano, C.P. Eduardo, et al., Photobiomodul. Photomed. Laser Surg. 37 (2019) 262-266. doi: 10.1089/photob.2018.4575
31. [31]
  F.F. Küçükekenci, A.S. Küçükekenci, F. Çakici, Odontology 107 (2019) 186-189. doi: 10.1007/s10266-018-0385-y
32. [32]
  A. Dilsiz, T. Aydin, V. Canakci, M. Gungormus, Photomed. Laser Surg. 28 (Supp. 2) (2010) S11–S17.
33. [33]
  A. Sicilia, S. Cuesta-Frechoso, A. Suárez, et al., J. Clin. Periodontol. 36 (2009) 650-660. doi: 10.1111/j.1600-051X.2009.01433.x
34. [34]
  F.A. Rizzante, R.M. Maenosono, M.A. Duarte, et al., J. Periodontol. 87 (2016) 320-326. doi: 10.1902/jop.2015.150444
35. [35]
  R. Praveen, S. Thakur, M. Kirthiga, M. Narmatha, J. Conserv. Dent. 21 (2018) 495-499. doi: 10.4103/JCD.JCD_197_18
36. [36]
  S. Oh, Y. Gu, H. Perinpanayagam, et al., Lasers Med. Sci. 33 (2018) 1237-1244. doi: 10.1007/s10103-018-2464-2
37. [37]
  H.B. Kara, U. Cakan, B. Yilmaz, P.I. Kurugol, J. Esthet. Restor. Dent. 28 (2016) 405-411. doi: 10.1111/jerd.12230
38. [38]
  P.I. Demydova, J. Stomatol. 73 (2020) 170-175. doi: 10.5114/jos.2020.98312
39. [39]
  L.M.S. Al-Saud, H.N.A. Al-Nahedh, Oper. Dent. 37 (2012) 340-355. doi: 10.2341/10-188-L
40. [40]
  A. Dilsiz, T. Aydın, G. Emrem, Photomed. Laser Surg. 28 (Supp. 2) (2010) S69–S74.
41. [41]
  K. Orhan, U. Aksoy, D.C. Can-Karabulut, A. Kalender, Lasers Med. Sci. 26 (2011) 591-598. doi: 10.1007/s10103-010-0794-9
42. [42]
  A.L. Marsilio, J.R. Rodrigues, A.B. Borges, J. Clin. Laser Med. Surg. 21 (2003) 291-296. doi: 10.1089/104454703322564505
43. [43]
  M.S. Noya, R.B. Bezerra, J.L. Lopes, A.L.B. Pinheiro, J. Appl. Oral Sci. 12 (2004) 363-366. doi: 10.1590/S1678-77572004000400021
44. [44]
  H.G. Yilmaz, S. Kurtulmus-Yilmaz, E. Cengiz, H. Bayindir, Y. Aykac, J. Dent. 39 (2011) 249-254. doi: 10.1016/j.jdent.2011.01.003
45. [45]
  M. Asnaashari, M. Moeini, J. Lasers Med. Sci. 4 (2013) 1-7.
46. [46]
  D. Mehta, V. Gowda, W.J. Finger, K. Sasaki, Dent. Mater. 31 (2015) 1298-1303. doi: 10.1016/j.dental.2015.08.162
47. [47]
  H.G. Yilmaz, E. Cengiz, S. Kurtulmus-Yilmaz, B. Leblebicioglu, J. Clin. Periodontol. 38 (2011) 341-346. doi: 10.1111/j.1600-051X.2010.01694.x
48. [48]
  A.O. Lopes, C. d. P. Eduardo, A.C.C. Aranha, Lasers Med. Sci. 32 (2017) 1023-1030. doi: 10.1007/s10103-017-2203-0
49. [49]
  A.O. Lopes, C. d. P. Eduardo, A.C.C. Aranha, Lasers Med. Sci. 30 (2015) 823-829. doi: 10.1007/s10103-013-1441-z
50. [50]
  A.O. Lopes, A.C.C. Aranha, Photomed. Laser Surg. 31 (2013) 132-138. doi: 10.1089/pho.2012.3386
51. [51]
  E.M.R. Lee, R. Borges, J. Marchi, C. d. P. Eduardo, M.M. Marques, J. Biomed. Mater. Res. 108 (2020) 939-947. doi: 10.1002/jbm.b.34446
52. [52]
  H.Q. Gao, L.R. Zhang, X.L. Lian, et al., Mater. Chem. Front. 5 (2021) 3388-3395. doi: 10.1039/d0qm01006e
53. [53]
  L. Zach, G. Cohen, Oral Surg. Oral Med. Oral Pathol. 19 (1965) 515-530. doi: 10.1016/0030-4220(65)90015-0
54. [54]
  J.J. Sauk, K. Norris, R.A. Foster, J.M. Moehring, M.J. Somerman, J. Oral Pathol. Med. 17 (1988) 496-498. doi: 10.1111/j.1600-0714.1988.tb01323.x
55. [55]
  M. Toledano, R. Osorio, E. Osorio, et al., J. Mech. Behav. Biomed. Mater. 68 (2017) 62-79. doi: 10.1016/j.jmbbm.2017.01.026
56. [56]
  M. Toledano-Osorio, E. Osorio, F.S. Aguilera, et al., Acta Biomater. 72 (2018) 371-380. doi: 10.1016/j.actbio.2018.03.033
57. [57]
  S.L. Tan, S.S. Chen, Y.F. Wang, et al., Dent. Mater. 36 (2020) 816-825. doi: 10.1016/j.dental.2020.03.028
58. [58]
  P. Usai, V. Campanella, G. Sotgiu, et al., Nanomaterials 9 (2019) 1748-1757. doi: 10.3390/nano9121748
59. [59]
  M.J. Zhu, J.L. Li, B. Chen, et al., PLoS One 10 (2015) e0140176. doi: 10.1371/journal.pone.0140176
60. [60]
  N.X. West, T. He, Y.S. Zou, et al., J. Dent. 105 (2021) 103566. doi: 10.1016/j.jdent.2020.103566
61. [61]
  J. Creeth, R. Maclure, J. Seong, et al., J. Clin. Periodontol. 46 (2019) 1105-1115. doi: 10.1111/jcpe.13175
62. [62]
  S.H. Joao-Souza, L.O. Sakae, A. Lussi, et al., Clin. Oral Investig. 24 (2020) 2051-2060. doi: 10.1007/s00784-019-03069-7
63. [63]
  Z.Y. Yang, F. Wang, K. Lu, Y.H. Li, Z. Zhou, Clin. Cosmet. Investig. Dent. 8 (2016) 1-14. doi: 10.1155/2016/6136178
64. [64]
  R. Monterubbianesi, V. Tosco, T. Bellezze, et al., Materials 14 (2021) 3072-3082. doi: 10.3390/ma14113072
65. [65]
  B.M. Souza, L.P. Comar, M. Vertuan, et al., Caries Res. 49 (2015) 499-507. doi: 10.1159/000438466
66. [66]
  P.Y. Yuan, X.Q. Shen, J. Liu, et al., PLoS One 7 (2012) e45283. doi: 10.1371/journal.pone.0045283
67. [67]
  L.D. Esposti, A.C. Ionescu, E. Brambilla, A. Tampieri, M. Iafisco, Materials 13 (2020) 2928-2940. doi: 10.3390/ma13132928
68. [68]
  P.Y. Yuan, S.Y. Liu, Y.T. Lv, et al., Int. J. Nanomed. 14 (2019) 5243-5256. doi: 10.2147/ijn.s205804
69. [69]
  A.R. PradeepKumar, V. Viswanath, K. Singh, et al., J. Conserv. Dent. 22 (2019) 522-528. doi: 10.4103/jcd.jcd_22_20
70. [70]
  S.J. Khunkar, S. Utaka, I. Hariri, et al., Arch. Oral Biol. 60 (2015) 574-581. doi: 10.1016/j.archoralbio.2015.01.001
71. [71]
  D. Hines, S.Y. Xu, M. Stranick, J. Am. Dent. Assoc. 150 (2019) S47-S59. doi: 10.1016/j.adaj.2019.01.006
72. [72]
  T. Matsuura, M. Mae, M. Ohira, et al., Trials 21 (2020) 1-6. doi: 10.1080/23320885.2019.1704290
73. [73]
  A. Saad, T. Nikaido, A. Abdou, et al., Dent. Mater. J. 38 (2019) 940-946. doi: 10.4012/dmj.2018-352
74. [74]
  T. Suge, A. Kawasaki, K. Ishikawa, T. Matsuo, S. Ebisu, Dent. Mater. 24 (2008) 192-198. doi: 10.1016/j.dental.2007.03.009
75. [75]
  D.S. Brauer, N. Karpukhina, M.D. O'Donnell, R.V. Law, R.G. Hill, Acta Biomater. 6 (2010) 3275-3282. doi: 10.1016/j.actbio.2010.01.043
76. [76]
  Y. Cao, M.L. Mei, J.G. Xu, et al., J. Dent. 41 (2013) 818-825. doi: 10.1016/j.jdent.2013.06.008
77. [77]
  Q.Q. Wang, S.Q. Wang, T. Zhao, et al., J. Appl. Biomater. Funct. Mater. 19 (2021) 33784188.
78. [78]
  Y.H. Park, C. Son, Y.M. Seo, et al., Front. Cell Dev. Biol. 9 (2021) 655498. doi: 10.3389/fcell.2021.655498
79. [79]
  J. Figueiredo-Macedo-de-Lima, M. d. C. Aguiar-Jordão-Mainardi, R.M. Puppin-Rontani, et al., Dent. Mater. 36 (2020) 501-511. doi: 10.1016/j.dental.2020.01.012
80. [80]
  Y.Z. Zhou, Y. Cao, W. Liu, C.H. Chu, Q.L. Li, ACS Appl. Mater. Interfaces 4 (2012) 6901-6910. doi: 10.1021/am302041b
81. [81]
  D.X. Oh, E. Prajatelistia, S.W. Ju, et al., Sci. Rep. 5 (2015) 1-8.
82. [82]
  A.K.B. Bedran-Russo, K.J. Yoo, K.C. Ema, D.H. Pashley, J. Dent. Res. 88 (2009) 807-811. doi: 10.1177/0022034509342556
83. [83]
  E. Prajatelistia, S.W. Ju, N.D. Sanandiya, et al., Adv. Healthc. Mater. 5 (2016) 919-927. doi: 10.1002/adhm.201500878
84. [84]
  A. Zaharia, V.G. Plescan, E.M. Anghel, V. Musat, Rev. Chim. 68 (2017) 928-932. doi: 10.37358/rc.17.5.5583
85. [85]
  N.I.P. Pini, D.A.N.L. Lima, J.R. Lovadino, C. Ganss, N. Schlueter, Caries Res. 50 (2016) 337-345. doi: 10.1159/000445758
86. [86]
  J.H. Song, H.R. Wang, Y.Q. Yang, et al., J. Mater. Sci. Mater. Med. 29 (2018) 1-11.
87. [87]
  C. Li, D.Y. Lu, J.J. Deng, X. Zhang, P. Yang, Adv. Mater. 31 (2019) e1903973. doi: 10.1002/adma.201903973
88. [88]
  S. Srinivasan, R. Jayasree, K.P. Chennazhi, S.V. Nair, R. Jayakumar, Carbohydr. Polym. 87 (2012) 274-283. doi: 10.1016/j.carbpol.2011.07.058
89. [89]
  H. Autefage, F. Allen, H.M. Tang, et al., Biomaterials 209 (2019) 152-162. doi: 10.1016/j.biomaterials.2019.03.035
90. [90]
  W. Niu, M. Chen, Y. Guo, et al., ACS Nano 15 (2021) 14323-14337. doi: 10.1021/acsnano.1c03214
91. [91]
  S. Kargozar, F. Baino, S. Hamzehlou, R.G. Hill, M. Mozafari, Trends Biotechnol. 36 (2018) 430-444. doi: 10.1016/j.tibtech.2017.12.003
92. [92]
  K. Sawant, A.M. Pawar, Saudi J. Oral Sci. 7 (2020) 3-10. doi: 10.4103/sjos.SJOralSci_56_19
93. [93]
  X.Y. Sheng, W.Y. Gong, Q. Hu, X.F. Chen, Y.M. Dong, Chin. Chem. Lett. 27 (2016) 1509-1514. doi: 10.1016/j.cclet.2016.03.030
94. [94]
  A.R. Curtis, N.X. West, B. Su, Acta Biomater. 6 (2010) 3740-3746. doi: 10.1016/j.actbio.2010.02.045
95. [95]
  J.C. Mitchell, L. Musanje, J.L. Ferracane, Dent. Mater. 27 (2011) 386-393. doi: 10.1016/j.dental.2010.11.019
96. [96]
  E. Lynch, D.S. Brauer, N. Karpukhina, D.G. Gillam, R.G. Hill, Dent. Mater. 28 (2012) 168-178. doi: 10.1016/j.dental.2011.11.021
97. [97]
  T.C.C. Lopez, I.M.A. Diniz, L.S. Ferreira, et al., J. Biomed. Mater. Res., Part B 105 (2017) 107-116. doi: 10.1002/jbm.b.33532
98. [98]
  Y.C. Chiang, H.P. Lin, H.H. Chang, et al., ACS Nano 8 (2014) 12502-12513. doi: 10.1021/nn5053487
99. [99]
  M.A. Malkoç, M. Sevimay, Lasers Med. Sci. 27 (2012) 743-748. doi: 10.1007/s10103-011-0954-6
100. [100]
  M.M. Moreira, L.R.R. d. Silva, T.A.D. Mendes, et al., Dent. Mater. 34 (2018) 1144-1153. doi: 10.1016/j.dental.2018.04.011
101. [101]
  P. Schüpbach, F. Lutz, W.J. Finger, Eur. J. Oral Sci. 105 (1997) 414-421. doi: 10.1111/j.1600-0722.1997.tb02138.x
102. [102]
  A. Bechir, V. Hancu, G. Ciavoi, et al., Acta Stomatol. Marisiensis 1 (2018) 74-81.
103. [103]
  Y. Zhou, M. Yang, Q.J. Jia, et al., ACS Omega 6 (2021) 19596-19605. doi: 10.1021/acsomega.1c02123
104. [104]
  B. Allard, H. Magloire, M.L. Couble, J.C. Maurin, F. Bleicher, J. Biol. Chem. 281 (2006) 29002-29010. doi: 10.1074/jbc.M601020200
105. [105]
  A. Alloui, K. Zimmermann, J. Mamet, et al., EMBO J. 25 (2006) 2368-2376. doi: 10.1038/sj.emboj.7601116
106. [106]
  M.Z. Hossain, M.M. Bakri, F. Yahya, et al., Int. J. Mol. Sci. 20 (2019) 526-556. doi: 10.3390/ijms20030526
107. [107]
  X. Liu, C. Wang, T. Fujita, et al., J. Dent. Res. 94 (2015) 1259-1266. doi: 10.1177/0022034515592858
108. [108]
  J.J. Ryu, S. Yoo, K.Y. Kim, et al., J. Dent. Res. 89 (2010) 1455-1460. doi: 10.1177/0022034510381394
109. [109]
  B.B. Lier, C.K. Rösing, A.M. Aass, P. Gjermo, J. Clin. Periodontol. 29 (2002) 501-506. doi: 10.1034/j.1600-051X.2002.290605.x
110. [110]
  Y. Kimura, P. Wilder-Smith, K. Yonaga, K. Matsumoto, J. Clin. Periodontol. 27 (2000) 715-721. doi: 10.1034/j.1600-051x.2000.027010715.x
111. [111]
  S.M. Al-Qahtani, Open Access Maced. J. Med. Sci. 7 (2019) 1685-1690. doi: 10.3889/oamjms.2019.344
112. [112]
  S.M.A. Silva, J. Malacarne-Zanon, R.M. Carvalho, et al., Oper. Dent. 37 (2012) 356-362. doi: 10.2341/09-228-L
113. [113]
  D.G. Gillam, N. Khan, N.J. Maidan, P.M. Barbe, Dent. Traumatol. 15 (1999) 198-204. doi: 10.1111/j.1600-9657.1999.tb00774.x
114. [114]
  A.C. Machado, F.E.M. Rabelo, V. Maximiano, et al., J. Dent. 86 (2019) 53-59. doi: 10.1016/j.jdent.2019.05.025
115. [115]
  N. Wara-aswapati, D. Krongnawakul, D. Jiraviboon, et al., J. Clin. Periodontol. 32 (2005) 53-58. doi: 10.1111/j.1600-051X.2004.00631.x
116. [116]
  E. Zarzecka-Francica, J. Golda, O. Gornicka, et al., Folia Med. Cracov. 2 (2020) 43-54.
117. [117]
  P. Amini, M. Miner, P.A. Sagel, R.W. Gerlach, Compend. Contin. Educ. Dent. 37 (2016) e21-e25.
118. [118]
  J.M. Peacock, R. Orchardson, J. Clin. Periodontol. 26 (1999) 33-37. doi: 10.1034/j.1600-051x.1999.260106.x
119. [119]
  K. McCormack, R. Davies, Pain 68 (1996) 5-11. doi: 10.1016/S0304-3959(96)03142-9
120. [120]
  M.F. Cuenin, M.J. Scheidt, R.B. O'Neal, et al., J. Clin. Periodontol. 62 (1991) 668-673. doi: 10.1902/jop.1991.62.11.668
1. [1]
  Chao Zhang , Ai-Feng Liu , Shihui Li , Fang-Yuan Chen , Jun-Tao Zhang , Fang-Xing Zeng , Hui-Chuan Feng , Ping Wang , Wen-Chao Geng , Chuan-Rui Ma , Dong-Sheng Guo . A supramolecular formulation of icariin@sulfonatoazocalixarene for hypoxia-targeted osteoarthritis therapy. Chinese Chemical Letters, 2025, 36(1): 109752-. doi: 10.1016/j.cclet.2024.109752
2. [2]
  Yang Xu , Le Ma , Yang Wang , Chunmeng Shi . Engineering strategies of biomaterial-assisted exosomes for skin wound repair: Latest advances and challenges. Chinese Chemical Letters, 2025, 36(1): 109766-. doi: 10.1016/j.cclet.2024.109766
3. [3]
  Jing Zhang , Charles Wang , Yaoyao Zhang , Haining Xia , Yujuan Wang , Kun Ma , Junfeng Wang . Application of magnetotactic bacteria as engineering microrobots: Higher delivery efficiency of antitumor medicine. Chinese Chemical Letters, 2024, 35(10): 109420-. doi: 10.1016/j.cclet.2023.109420

Get Citation

PDF

XML

Metrics

PDF Downloads(4)
Abstract views(398)
HTML views(15)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142