Citation: Zhonghua Li, Jianmin Zhou, Xin Zhang, Songgu Wu, Junbo Gong. Exploring the influence of crystal packing on the optical-physical property of quercetin-based binary and ternary solid forms[J]. Chinese Chemical Letters, ;2023, 34(6): 107983. doi: 10.1016/j.cclet.2022.107983 shu

Exploring the influence of crystal packing on the optical-physical property of quercetin-based binary and ternary solid forms

Zhonghua Li ^{a, 1} ,
Jianmin Zhou ^{a, 1} ,
Xin Zhang ^a ,
Songgu Wu ^{a, *,} ,
Junbo Gong ^{a, b, c, *,}

a.
State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China
b.
Chemistry and Chemical Engineering Guangdong Laboratory, Shantou 515031, China
c.
Haihe Laboratory of Sustainable Chemical Transformations, Tianjin 300192, China

wusonggu@tju.edu.cn

junbo_gong@tju.edu.cn

Received Date: 8 September 2022
Revised Date: 28 October 2022
Accepted Date: 3 November 2022
Available Online: 5 November 2022

Figures(4)

The co-crystallization of quercetin (Qur) with a flexible molecule 4-(4-pyridinyldisulfanyl) pyridine (DPDS) in different solvents and conditions was investigated, yielded five multi-component crystalline phases and characterized with X-ray diffractions and thermal analysis. Although the crystal system of Qur-DPDS-MeOH and Qur-DPDS-Dioxane is the same, the desolvation results revealed that Qur-DPDS-MeOH transformed to Qur-DPDS when MeOH solvent molecules escape from the lattice, while Qur-DPDS-Dioxane transformed to Qur-DPDS-Ⅱ through a similar process, which is same with Qur-DPDS-THF. These two cocrystal polymorphs Qur-DPDS and Qur-DPDS-Ⅱ obey an enantiotropic relationship. Moreover, the formation of cocrystal solvates improves the packing efficiency of crystals. Crystal structure analysis showed that hydrogen bonds and conformations of the corresponding parent molecules play a major role in molecular assembly and crystal packing patterns, thus bring different physicochemical properties. Finally, the fluorescence spectra and quantum-chemical calculations were carried out to explore the difference in the optical-physical properties.
- Natural plant pigment,
- Cocrystal,
- Solvate,
- Crystal structure,
- Molecular conformation,
- Intermolecular interaction
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