Citation: Yuerong Wang, Yang Lei, Jiaye Wang, Hui Yang, Leming Sun. Tetrapeptide self-assembled multicolor fluorescent nanoparticles for bioimaging applications[J]. Chinese Chemical Letters, ;2023, 34(6): 107915. doi: 10.1016/j.cclet.2022.107915 shu

Tetrapeptide self-assembled multicolor fluorescent nanoparticles for bioimaging applications

School of Life Sciences, Key Laboratory of Space Bioscience & Biotechnology, Northwestern Polytechnical University, Xi'an 710072, China

kittyyh@nwpu.edu.cn

lmsun@nwpu.edu.cn

Received Date: 13 August 2022
Revised Date: 12 October 2022
Accepted Date: 17 October 2022
Available Online: 19 October 2022

Figures(4)

The biocompatibility and biodegradability of peptide self-assembled materials makes them suitable for many biological applications, such as targeted drug delivery, bioimaging, and tracking of therapeutic agents. According to our previous research, self-assembled fluorescent peptide nanoparticles can overcome the intrinsic optical properties of peptides. However, monochromatic fluorescent nanomaterials have many limitations as luminescent agents in biomedical applications. Therefore, combining different fluorescent species into one nanostructure to prepare fluorescent nanoparticles with multiple emission wavelengths has become a very attractive research area in the bioimaging field. In this study, the tetrapeptide Trp-Trp-Trp-Trp (WWWW) was self-assembled into multicolor fluorescent nanoparticles (TPNPs). The results have demonstrated that TPNPs have the blue, green, red and near infrared (NIR) fluorescence emission wavelength. Moreover, TPNPs have shown excellent performance in multicolor bioimaging, biocompatibility, and photostability. The facile preparation and multicolor fluorescence features make TPNPs potentially useful in multiplex bioanalysis and diagnostics.
- Self-assembly,
- Tetrapeptide,
- Multicolor,
- Fluorescent nanoparticles,
- Bioimaging
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