Citation: Qi-Long Hu, Jia-Tian Liu, Guangjin Fan, Jian Li, Yixian Li, Albert S.C. Chan, Xiao-Feng Xiong. On-resin peptide modification of methionine residue by employing 2-bromoacetate derivatives[J]. Chinese Chemical Letters, ;2023, 34(4): 107730. doi: 10.1016/j.cclet.2022.08.010 shu

On-resin peptide modification of methionine residue by employing 2-bromoacetate derivatives

Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China

xiongxf7@mail.sysu.edu.cn

Received Date: 1 June 2022
Revised Date: 27 July 2022
Accepted Date: 5 August 2022
Available Online: 11 August 2022

Figures(4)

On-resin peptide modification renders an easy-to-operate method that combines solid-phase peptide synthesis efficiency and avoids tedious purification procedures. Herein, we report the transition-metal-free and redox-neutral approach for solid-phase Met diversification with substrate diversity, which could be applied to synthesize cyclic peptides of different sizes.
- Methionine,
- 2-Bromoacetate derivatives,
- On-resin modification,
- Peptide,
- Cyclization
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