Citation: Ping Wang, Yue Wang, Ping Li, Chen Chen, Siman Ma, Linxuan Zhao, Haibing He, Tian Yin, Yu Zhang, Xing Tang, Jingxin Gou. Oral delivery of polyester nanoparticles for brain-targeting: Challenges and opportunities[J]. Chinese Chemical Letters, ;2023, 34(4): 107691. doi: 10.1016/j.cclet.2022.07.034 shu

Oral delivery of polyester nanoparticles for brain-targeting: Challenges and opportunities

Ping Wang ^{a, b} ,
Yue Wang ^{a, b} ,
Ping Li ^b ,
Chen Chen ^b ,
Siman Ma ^a ,
Linxuan Zhao ^b ,
Haibing He ^a ,
Tian Yin ^c ,
Yu Zhang ^a ,
Xing Tang ^a ,
Jingxin Gou ^{a, *,}

a.
Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China
b.
School of Pharmacy, Jilin University, Changchun 130021, China
c.
School of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, China

jxgou_syphu@163.com

Received Date: 14 January 2022
Revised Date: 14 July 2022
Accepted Date: 15 July 2022
Available Online: 19 July 2022

Figures(6)

Efficient oral delivery of drugs treating brain diseases has long been a challenging topic faced by the drug delivery community. Fortunately, polyester nanoparticles offer certain solutions to this problem. This review article firstly describes the main obstacles faced by oral administered brain targeting, including: (1) instability in the gastrointestinal tract; (2) poor penetration of the intestinal mucosa and epithelium; (3) blood clearance; and (4) restriction by the BBB. Then the key factors influencing brain-targeting efficiency of orally administered polyester nanoparticles are also discussed, such as size, shape and surface properties. Finally, recent brain-targeting delivery strategies using oral polyester nanoparticles as carriers and their effects on brain drugs transport are reviewed, and the delivery 'as a whole' strategy of polyester nanoparticles will provide new insight for oral brain-targeting delivery. And by combination of multiple strategies, both the stability and permeability of polyester nanoparticles can be greatly improved for oral brain drug delivery.
- Polyester nanoparticles,
- Oral brain drugs,
- Brain-targeted delivery,
- Physiological barrier,
- Absorption enhancement
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